Water mediated eco-friendly green protocol for one-pot synthesis of α-aminophosphonates at ambient conditions

Abstract

Increasing environmental awareness and economic concerns have led to the consideration of highly efficient one-pot, three-component, green approaches for important organic synthons. We describe here a simple, elegant and high yielding protocol for the synthesis of α-aminophosphonates in totally solvent-free, catalyst-free conditions by reacting aldehydes, amines and trimethyl phosphite at ambient temperature.

An Eco‐friendly Three Component Manifold for the Synthesis of α‐Aminophosphonates under Catalyst and Solvent‐free Conditions, X‐ray Characterization and Their Evaluation as Anticancer Agents

“…42 However, most of these methods have drawbacks, have drawbacks, because they use toxic and/or expensive catalysts and polluting organic solvents, have unsatisfactory yields or involve difficult preparations, prolonged reaction times and harsh reaction conditions, therefore researchers have been developed various eco-friendly method for their synthesis. [43][44][45][46][47][48][49] As part of our continuous efforts to develop a green, ecofriendly, general and cost effective protocol for synthesis a-aminophosphonates, we have been reported an efficient and eco-friendly green one-pot multi-component protocol for the synthesis of a-aminophosphonate derivatives in excellent yields via a one-pot three component condensation of various aldehydes, amines and diethyl phosphite under catalyst and solvent-free conditions. The cytotoxic activity of the newly synthesized a-aminophosphonates (4a-p) on the cancer cell line DU145 was also studied using the MTT method and as the result compounds 4b & 4d proved to be potential cancer cytotoxic agents.…”