Water extract of Cinnamomum cassia Blume inhibited human respiratory syncytial virus by preventing viral attachment, internalization, and syncytium formation

Yeh, Chia Feng; Chang, Jung San; Wang, Kuo Chih; Shieh, Den En; Chiang, Lien Chai

doi:10.1016/j.jep.2013.03.010

Cited by 30 publications

(11 citation statements)

References 26 publications

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“…The transgenic plant proteins showed high efficacy against the virus as reported by Hu et al [30]. Previous studies illustrate that the water extracts were effective against viral pathogens [31, 32] but because of the high flavonoid content in ESM extract the antiviral activity was more when compared with ESW. The water extracts against pathogenic virus were studied before and showed good results.…”

Section: Resultsmentioning

confidence: 72%

Metabolic Variations, Antioxidant Potential, and Antiviral Activity of Different Extracts ofEugenia singampattiana(an Endangered Medicinal Plant Used by Kani Tribals, Tamil Nadu, India) Leaf

John

Ayyanar²,

Jeeva

et al. 2014

BioMed Research International

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Eugenia singampattiana is an endangered medicinal plant used by the Kani tribals of South India. The plant had been studied for its antioxidant, antitumor, antihyperlipidemic, and antidiabetic activity. But its primary and secondary metabolites profile and its antiviral properties were unknown, and so this study sought to identify this aspect in Eugenia singampattiana plant through different extraction methods along with their activities against porcine reproductive and respiratory syndrome virus (PRRSV). The GC-MS analysis revealed that 11 primary metabolites showed significant variations among the extracts. Except for fructose all other metabolites were high with water extract. Among 12 secondary metabolites showing variations, the levels of 4-hydroxy benzoic acid, caffeic acid, rutin, ferulic acid, coumaric acid, epigallocatechin gallate, quercetin, myricetin, and kaempferol were high with methanol extract. Since the flavonoid content of methanol extracts was high, the antioxidant potential, such as ABTS, and phosphomolybdenum activity increased. The plants antiviral activity against PRRSV was for the first time confirmed and the results revealed that methanol 25 µg and 75 to 100 µg in case of water extracts revealed antiviral activity.

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Section: Resultsmentioning

confidence: 72%

Metabolic Variations, Antioxidant Potential, and Antiviral Activity of Different Extracts ofEugenia singampattiana(an Endangered Medicinal Plant Used by Kani Tribals, Tamil Nadu, India) Leaf

John

Ayyanar²,

Jeeva

et al. 2014

BioMed Research International

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“…Studies demonstrated that the plant has inhibitory effects on RNA viral infections in vitro. 27,28 Zhuang et al also showed that a cinnamon extract inhibited an infection with the wild type SARS-CoV in vitro (IC 50 ¼ 43 mM). 29 The proposed possible mechanism was blocking cell entry via endocytosis.…”

Section: Cinnamonmentioning

confidence: 98%

Effects of Gene-Eden-VIR and Novirin on SARS-CoV: Implications for COVID-19

Polansky

Lori

2020

J Evid Based Complementary Altern Med

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The coronavirus (SARS-CoV-2), which causes COVID-19, is a betacoronavirus closely related to the human severe acute respiratory syndrome (SARS)-coronavirus (SARS-CoV). The recent COVID-19 outbreak created an urgent need for treatment. To expedite the development of such treatment, pharmaceutical companies and government agencies are currently testing several existing drugs for their effect on the virus. Gene-Eden-VIR and Novirin are natural, broad-spectrum, antiviral treatments proven to be safe and effective in several clinical studies. In this article, we present evidence indicating that the 5 Gene-Eden-VIR/Novirin ingredients have anti-betacoronavirus, and specifically, anti-SARS-CoV effects. We consider this evidence as a first indication of the anti-coronavirus effects of Gene-Eden-VIR/Novirin. Next, we are planning to conduct a clinical study with users of the treatments to test the effects of Gene-Eden-VIR/Novirin on individuals at risk and those infected with the virus.

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“…It had an EC50 of 0.16 nM, 100,000 times better than that of ribavirin. This compound showed anti-fusion activity against RSV in a dual mode of action including prevention of cell-virus fusion activity as well as cell-cell Promising but conclusive studies required [158][159][160][161][162][163][164] 16…”

Section: Fusion Inhibitorsmentioning

confidence: 99%

“…The plant extracts from Cinnamomum cassia, Cimicifuga foetida, Sheng-Ma-Ge-Gen-Tang (SMGGT) (Shoma-kakkon-to), Xiao-Qing-Long-Tang (Sho-seiryu-to, so-cheong-ryong-tang), Ge-Gen-Tang, and Ginger (Zingiber officinale) show anti-RSV activity. These extracts probably inhibit RSV infection by blocking the F protein binding to the cell and some of the extracts even stimulate IFN-production [158][159][160][161][162][163]. Some decoctions like modified Dingchuan (consists of Salviae miltiorrhizae radix, Scutellariae radix, Farfarae flos and Ephedrae herba), Liu-He-Tang (consist of 13 plant extract), and water extracts of Licorice (Radix glycyrrhizae and Radix glycyrrhizae Preparata) have shown effectiveness against RSV in vitro.…”

Section: Ethnobotanicalsmentioning

confidence: 99%

Recent Advances in Diagnosis, Prevention, and Treatment of Human Respiratory Syncytial Virus

Bawage

Tiwari

Pillai

et al. 2013

Advances in Virology

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Human respiratory syncytial virus (RSV) is a common cause of respiratory infection in infants and the elderly, leading to significant morbidity and mortality. The interdisciplinary fields, especially biotechnology and nanotechnology, have facilitated the development of modern detection systems for RSV. Many anti-RSV compounds like fusion inhibitors and RNAi molecules have been successful in laboratory and clinical trials. But, currently, there are no effective drugs for RSV infection even after decades of research. Effective diagnosis can result in effective treatment, but the progress in both of these facets must be concurrent. The development in prevention and treatment measures for RSV is at appreciable pace, but the implementation into clinical practice still seems a challenge. This review attempts to present the promising diverse research approaches and advancements in the area of diagnosis, prevention, and treatment that contribute to RSV management.

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Water extract of Cinnamomum cassia Blume inhibited human respiratory syncytial virus by preventing viral attachment, internalization, and syncytium formation

Cited by 30 publications

References 26 publications

Metabolic Variations, Antioxidant Potential, and Antiviral Activity of Different Extracts ofEugenia singampattiana(an Endangered Medicinal Plant Used by Kani Tribals, Tamil Nadu, India) Leaf

Metabolic Variations, Antioxidant Potential, and Antiviral Activity of Different Extracts ofEugenia singampattiana(an Endangered Medicinal Plant Used by Kani Tribals, Tamil Nadu, India) Leaf

Effects of Gene-Eden-VIR and Novirin on SARS-CoV: Implications for COVID-19

Recent Advances in Diagnosis, Prevention, and Treatment of Human Respiratory Syncytial Virus

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