Water-Enabled H₂ Generation from Hydrogenated Silicon Nanosheets for Efficient Anti-Inflammation

Abstract

As an emerging therapeutic gas, hydrogen (H2) is gifted with excellent biosafety, high tissue permeability, and radical-trapping capacity and is extensively considered as a highly promising antioxidant in clinics. However, a facile and effective strategy of H2 production for major inflammatory disease treatments is still lacking. In this study, by a facile wet-chemical exfoliation synthesis, a hydrogen-terminated silicon nanosheet (H-silicene) has been synthesized, which can favorably react with environmental water to generate H2 rapidly and continuously without any external energy input. Furthermore, theoretical calculations were employed to reveal the mechanism of enhanced H2 generation efficacy of H-silicene nanosheets. The as-synthesized H-silicene has been explored as a flexible hydrogen gas generator for efficient antioxidative stress application for the first time, which highlights a promising prospect of this two-dimensional H-silicene nanomaterial for acute inflammatory treatments by on-demand H2 production-enabled reactive oxygen species scavenging. This study provides a novel and efficient modality for nanomaterial-mediated H2 therapy.

Structure, Stability, and Electronic Properties of Hydrogenated Monolayer 2D Silicon Allotropes by First‐Principles Calculation

“…In addition, all of these monolayer 2D silicon allotropes have high gravimetric hydrogen contents and maybe have applications for chemical hydrogen storage or water‐enabled H 2 production. [ 54–57 ] We believe that the results of this work have a good reference value for the experimental synthesis of hydrogenated monolayer 2D silicon allotropes, and have reference significance for understanding the diversity and electronic properties of hydrogenated monolayer 2D silicon allotropes.…”

Interface-Enhanced SiOx/Ru Heterocatalysts for Efficient Electrochemical Water Splitting

“…It is worth noting that no diffraction peaks of SiO 2 can be clearly observed, indicating that SiO 2 in SiO x /Ru NSs has an amorphous structure. As confirmed by FTIR spectroscopy (Figures b and S4a), compared with that of Ru NSs and SiO 2 NPs, the broad band of SiO x /Ru NSs at 1015 cm –1 corresponds to the Si–O stretching vibration, confirming the successful introduction of SiO x and the existence of the Ru–O–Si interface . EPR spectra of SiO x /Ru NSs exhibit a typical signal of oxygen vacancy at g = 2.003 (Figures c and S4b).…”

“…As confirmed by FTIR spectroscopy (Figures 2b and S4a), compared with that of Ru NSs and SiO 2 NPs, the broad band of SiO x /Ru NSs at 1015 cm −1 corresponds to the Si−O stretching vibration, confirming the successful introduction of SiO x and the existence of the Ru−O−Si interface. 25 EPR spectra of SiO x /Ru NSs exhibit a typical signal of oxygen vacancy at g = 2.003 (Figures 2c and S4b). 26 It is worth noting that the reference samples of Ru NSs and SiO 2 NPs did not exhibit obvious EPR signals, indicating that when SiO 2 and Ru formed the Ru−O−Si heterointerface, the additional defects are introduced due to the lattice distortion.…”

Piezo‐Augmented and Photocatalytic Nanozyme Integrated Microneedles for Antibacterial and Anti‐Inflammatory Combination Therapy

“…[24] You et al synthesized hydrogen-terminated silicon nanosheet (H-silicene) as a flexible H 2 gas nanogenerator for acute inflammatory treatments. [25] Hence, the H 2 gas nanogenerators can be employed as antiinflammatory therapeutics for wound infections.…”