Piezo‐Augmented and Photocatalytic Nanozyme Integrated Microneedles for Antibacterial and Anti‐Inflammatory Combination Therapy

Abstract

Wound infection is arguably the most common, and potentially the most devastating, complication of the wound healing process. The ideal treatment strategy has to eliminate bacteria, alleviate inflammation, and promote wound healing and skin formation. Herein, a multifunctional heterostructure is designed consisting of ultrasmall platinum–ruthenium nanoalloys and porous graphitic carbon nitride C3N5 nanosheets (denoted as PtRu/C3N5), which concurrently possesses piezoelectric enhanced oxidase ‐mimic nanozyme activity and photocatalytic hydrogen gas production capacity. Moreover, these hybrid nanotherapeutics are integrated in natural hyaluronic acid microneedles, which exhibit almost 100% broad‐spectrum antibacterial efficacy against multiple bacterial strains in vitro and in vivo within 10 min ultrasound treatment, and effectively inhibit inflammation reactions after 1 h visible light irradiation, promising for accelerating the cutaneous wound healing in the bacterial infected mice. This study highlights a competitive strategy for development of all‐in‐one antibacterial and anti‐inflammatory therapies.

Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

“…Composed of ultrafine Pt–Ru nanoalloys and porous graphitic carbon nitride C 3 N 5 nanosheets, the materials (PtRu/C 3 N 5 ) with the capability of both piezoelectrically enhanced oxidase‐mimic nanoparticle activity and photocatalytic H 2 production, can simultaneously achieve antibacterial and anti‐inflammatory effects of wound infections in a short time. [ 60 ]…”

Microneedles for in situ tissue regeneration

“… [ 121 ] Silk fibroin, silicon Arrays:- Height:- Shape: conical Strength: 0.5 ​N/Needle VEGF Porous structures enhanced the drug loading capability; Liquid diffused along the microfluidic channel for detecting biomarkers in wound secretion; Microelectronic circuits were integrated to sense the motion state of wound areas. [ 123 ] HA Arrays:- Height: 600 ​μm Shape: conical Strength: Platinum–ruthenium nanoalloys and porous graphitic carbon nitride C3N5 nanosheets Improving transdermal drug delivery efficiency [ 124 ] …”

Functional insights to the development of bioactive material for combating bacterial infections

“…The modification of microneedles and their substrate materials is a proven strategy to enhance microneedle drug delivery (Su et al, 2020;Deng et al, 2022). Shi et al (2023) loaded platinum ruthenium nanoalloy modified nanosheets onto hyaluronic acid-based microneedles and applied nanozyme antibacterial therapy, which showed good antibacterial and antiinflammatory properties. González García et al (2019) prepared carboxymethyl cellulose based microneedles containing AgNPs, and the results showed that they had significant antibacterial activity against both gram negative and positive bacteria.…”