Water-dispersed fluorescent silicon nanodots as probes for fluorometric determination of picric acid via energy transfer

Qi, Wenjing; He, Hongkun; Fu, Yuling; Zhao, Maoyu; Lin, Qi; Hu, Lianzhe; Liu, Chun; Rong, Li

doi:10.1007/s00604-018-3135-5

Cited by 15 publications

(3 citation statements)

References 29 publications

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“…As displayed in Figure , upon the addition of two different concentrations of bilirubin, the orange-red fluorescence of the cotton swab is quenched within 1 min. It is evident that the cotton swab sensor based on the OR-CDs can be employed for point-of-care detection of bilirubin as a jaundice biomarker in biofluids …”

Section: Resultsmentioning

confidence: 99%

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Orange-Red-Emitting Carbon Dots for Bilirubin Detection and Its Antibacterial Activity Against Escherichia coli and Staphylococcus aureus

Nandhini,

Ilanchelian

2024

ACS Appl. Bio Mater.

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In this study, orange-red-emitting carbon dots (OR-CDs) were prepared from p-phenylenediamine (p-PDA) and urea as starting precursors through the hydrothermal method. The OR-CDs exhibited bright orange-red fluorescence at 618 nm when excited at 480 nm. The obtained OR-CDs exhibited stable photophysical properties under different physiological conditions. The unique photophysical property of OR-CDs were then utilized for fluorometric determination of bilirubin. The fluorometric assay revealed that the fluorescence intensity of OR-CDs is gradually quenched upon the addition of bilirubin (1−20 μM). The mechanism of fluorescence quenching was evaluated by steadystate fluorescence analysis and time-correlated single photon counting measurements. The OR-CDs showed good selectivity and sensitivity toward bilirubin over other common interfering biomolecules. The present fluorometric assay showed a linear response toward bilirubin between 1 and 10 μM with a limit of detection of 4.80 nM. Further, a fluorescence test cotton swab-based detection probe has been successfully developed by incorporating OR-CDs for the point-of-care detection of bilirubin in biofluids. Furthermore, a light-emitting diode light that emits orange-red light was prepared by embedding the OR-CDs within the poly(vinyl alcohol) polymer matrix. Moreover, the antibacterial activity of OR-CDs was tested against Gram-negative Escherichia coli and Grampositive Staphylococcus aureus. The antibacterial efficacy of OR-CDs was demonstrated by various mechanisms, such as reactive oxygen species generation, destruction of cell structure, chemical binding to membrane, and surface wrapping. Interestingly, the survival assay against L929 fibroblast cells exhibits favorable biocompatibility and bioimaging.

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Section: Resultsmentioning

confidence: 99%

“…It is evident that the cotton swab sensor based on the OR-CDs can be employed for point-of-care detection of bilirubin as a jaundice biomarker in biofluids. 44 3.11. Antibacterial Action of OR-CDs.…”

Section: Optical Characterization Of Or-cdsmentioning

confidence: 99%

Orange-Red-Emitting Carbon Dots for Bilirubin Detection and Its Antibacterial Activity Against Escherichia coli and Staphylococcus aureus

Nandhini,

Ilanchelian

2024

ACS Appl. Bio Mater.

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“…Many methods for determining PA have been described. These methods have involved electrochemical methods, fluorescence detection, mass spectrometry, and surface-enhanced Raman spectroscopy [5][6][7]. Fluorescence methods have advantages over many other methods because they give short response times, are simple to perform, use cost-effective instrumentation, and are very sensitive and specific [8].…”

Section: Introductionmentioning

confidence: 99%

Sensitive detection of picric acid in an aqueous solution using fluorescent nonconjugated polymer dots as fluorescent probes

Liu

et al. 2021

Nanotechnology

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Nonconjugated polymer dots (NPDs) were successfully used as fluorescent probes to selectively and sensitively detect picric acid (PA). The NPDs were prepared from polyethylenimine and 1,4phthalaldehyde under mild conditions and had excitation and emission maxima of 351 and 474 nm, respectively. Fluorescence of the NPDs was efficiently quenched by PA through the inner filter effect because of the overlapping PA absorption band and NPD excitation spectrum. The NPDs allowed PA to be determined with a high degree of sensitivity. The linear range was 0-140 μM and the detection limit was 0.5 μM. The work involved developing a novel method for synthesizing NPDs and a promising platform for determining PA in environmental media.

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Preparation of nonconjugated fluorescent polymer nanoparticles for use as a fluorescent probe for detection of 2,4,6-trinitrophenol

Liu

Xie

et al. 2020

Anal Bioanal Chem

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Water-dispersed fluorescent silicon nanodots as probes for fluorometric determination of picric acid via energy transfer

Cited by 15 publications

References 29 publications

Orange-Red-Emitting Carbon Dots for Bilirubin Detection and Its Antibacterial Activity Against Escherichia coli and Staphylococcus aureus

Orange-Red-Emitting Carbon Dots for Bilirubin Detection and Its Antibacterial Activity Against Escherichia coli and Staphylococcus aureus

Sensitive detection of picric acid in an aqueous solution using fluorescent nonconjugated polymer dots as fluorescent probes

Preparation of nonconjugated fluorescent polymer nanoparticles for use as a fluorescent probe for detection of 2,4,6-trinitrophenol

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