Abstract:In the presence of normal renal function, a high concentration of aluminum in drinking water has been implicated as a factor in the etiology of a neurological syndrome in one specific geographical area. The role of aluminum as a toxic agent in other neurological disorders, where renal function is normal, is controversial.Aluminum is absorbed from the gastrointestinal tract and is normally excreted by the kidneys in the urine. In patients with chronic renal failure, aluminum appears to be of proven toxicologica… Show more
“…Conversely, a concomitant intake of aluminium with an increase of 10 mg/day in silica intake via drinking water was associated with a reduced risk of dementia (Rondeau et al 2009). Until the early 1980s aluminium in the dialysate appeared to be the major source of the metal in chronic renal failure patients who developed aluminium toxicity (Wills and Savory, 1985). As at that time adequate water purification systems were not available in all dialysis units, the aluminium concentration of the dialysate depended primarily on the aluminium concentration of the water with which it was prepared; whether further enriched with aluminium-contaminated chemicals or not in the concentrates which are added to the water to prepare the final dialysis fluids (D'Haese et al 1990).…”
Section: Aluminium Exposure and Toxicitymentioning
“…Conversely, a concomitant intake of aluminium with an increase of 10 mg/day in silica intake via drinking water was associated with a reduced risk of dementia (Rondeau et al 2009). Until the early 1980s aluminium in the dialysate appeared to be the major source of the metal in chronic renal failure patients who developed aluminium toxicity (Wills and Savory, 1985). As at that time adequate water purification systems were not available in all dialysis units, the aluminium concentration of the dialysate depended primarily on the aluminium concentration of the water with which it was prepared; whether further enriched with aluminium-contaminated chemicals or not in the concentrates which are added to the water to prepare the final dialysis fluids (D'Haese et al 1990).…”
Section: Aluminium Exposure and Toxicitymentioning
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