Aluminum ion in biological systems

Macdonald, T. L.; Martin, R. Bruce

doi:10.1016/0968-0004(88)90012-6

Cited by 297 publications

(169 citation statements)

References 18 publications

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“…In vitro studies have shown that Al does not inhibit tubulin polymerization, but promotes animal tubulin assembly and stability even in the absence of MAPs (MacDonald et al, 1987 ;MacDonald & Martin, 1988). This study shows for the first time in vivo that Al directly affects tubulin polymerization in plant cells, inducing the formation of abnormal MT systems.…”

Section: Possible Aluminium Target Mechanisms Underlying Microtubule mentioning

confidence: 83%

Aluminium effects on microtubule organization in dividing root‐tip cells of Triticum turgidum. I. Mitotic cells

2000

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The effects of aluminium (Al) on dividing root-tip cells of Triticum turgidum were investigated with tubulin immunolabelling and electron microscopy. Aluminium affects the mechanisms controlling the organization of microtubule (MT) cytoskeleton, as well as tubulin polymerization, and induces the following aberrations in mitotic cells. (1) It delays the MT disassembly during mitosis, resulting in the persistence of preprophase MT bands in the late prophase cells, the presence of prophase spindles in prometaphase cells, and a disturbance in the shortening of kinetochore MT bundles in anaphase cells. (2) It interferes with the self-organization process of MTs into bipolar systems, inhibiting the formation of prophase and metaphase spindles. (3) Aluminium induces the formation of atypical MT arrays, which in the immunofluorescent specimens appear as ring-like tubulin aggregations in the cortical cytoplasm of the preprophase\prophase cells and as endoplasmic tubulin bundles in prophase and metaphase\anaphase cells ; abnormal preprophase MT bands are assembled, consisting of atypical cortical and endoplasmic MT bundles, the latter clearly lining the nuclear envelope on the preprophase MT band plane. (4) It disorders the chromosome movements carried out by the mitotic spindle. In addition, after prolonged Al treatments chromatin condensation is inhibited. The outcome is greatly disturbed organization and function of the mitotic apparatus, as well as inhibition of cells from entering mitosis. This study shows that the MT cytoskeleton is a target site of Al toxicity in mitotic root-tip cells of T. turgidum. The possible mechanisms by which Al exerts its toxicity on MT organization and function are discussed.

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Section: Possible Aluminium Target Mechanisms Underlying Microtubule mentioning

confidence: 83%

Aluminium effects on microtubule organization in dividing root‐tip cells of Triticum turgidum. I. Mitotic cells

2000

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“…A previous study suggested that the antibacterial mechanism of aluminium by competition with iron and magnesium and binding to deoxyribonucleic acid (DNA), membranes or cell walls is responsible for the main toxic effect of aluminium on microbes (Pina and Cervantes, 1996). For example, aluminium binds almost 10 7 times more tightly to adenosine tri-phosphate (ATP) than magnesium does, indicating that aluminium concentrations lower than nanomolar concentrations are sufficient to compete with magnesium at millimolar concentrations (Macdonald and Martin, 1988;Pina and Cervantes, 1996). Our results indicated that aluminium had an antimicrobial property, and the rate of inactivation increased as temperature increased.…”

Section: Discussionmentioning

confidence: 99%

Effect of Aluminium Cookware on Escherichia coli during Pasteurization of Milk

Ruangthip

Kawamura

Uchida

et al. 2012

FSTR

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The effect of aluminium cookware on inactivation of Escherichia coli in milk was studied. Samples in aluminium and stainless-steel cups were heated at 60, 63, 65 and 67℃ and held at those temperatures for 25, 5, 3 and 2 min, respectively. Results obtained under the temperature of 65 and 67℃ clearly showed that cells of E. coli were killed more rapidly in aluminium cups than in stainless-steel cups. D-values in the aluminium cups were significantly shorter than those in stainless-steel cups, especially at higher temperatures. Samples in aluminium cups revealed a better trend inactivation effect than in stainless-steel cups at 60 and 63℃, however, there were no significant difference. Considering on z-values, results which obtained by aluminium cups were slightly lower than that obtained by stainless-steel cups. These results indicate that an aluminium utensil has an inactivating effect on E. coli and that rate of inactivation increases as temperature increases.

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“…In fact, aluminium is characterised by a probably unrivalled versatile chemistry, testimony to which is a huge number of applications for modern living (7,8) . Aluminium compounds contact human beings as a component of many cosmetic preparations, as aluminium salts, from use in the alimentary industry and also in pharmaceutical drugs.…”

Section: Introductionmentioning

confidence: 99%

The meaning of aluminium exposure on human health and aluminium-related diseases

Crisponi

Fanni²,

Gerosa³

et al. 2013

BioMolecular Concepts

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Abstract:The aim of this review is to attempt to answer extremely important questions related to aluminiumrelated diseases. Starting from an overview on the main sources of aluminium exposure in everyday life, the principal aspects of aluminium metabolism in humans have been taken into consideration in an attempt to enlighten the main metabolic pathways utilised by trivalent metal ions in different organs. The second part of this review is focused on the available evidence concerning the pathogenetic consequences of aluminium overload in human health, with particular attention to its putative role in bone and neurodegenerative human diseases.

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Aluminum ion in biological systems

Cited by 297 publications

References 18 publications

Aluminium effects on microtubule organization in dividing root‐tip cells of Triticum turgidum. I. Mitotic cells

Aluminium effects on microtubule organization in dividing root‐tip cells of Triticum turgidum. I. Mitotic cells

Effect of Aluminium Cookware on Escherichia coli during Pasteurization of Milk

The meaning of aluminium exposure on human health and aluminium-related diseases

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