Water content and binding in normal and osteoarthritic human cartilage

Mankin, H J; Thrasher, AZ

doi:10.2106/00004623-197557010-00013

Cited by 190 publications

(78 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, by 3 weeks the water content of IK cartilage was increased. In early stages of experimental osteoarthritis, in which decreased Safranin-0 staining and defective PG aggregation also occur, a similar increase in water content has been noted (22).…”

Section: Discussionsupporting

confidence: 56%

Development and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization

Palmoski

Perricone

Brandt

1979

Arthritis & Rheumatism

282

131

View full text Add to dashboard Cite

Healthy adult dogs were studied for a defect in proteoglycan aggregation by immobilizing one limb for varying periods of time. Immobilization for 6 days resulted in a 41% reduction in proteoglycan synthesis by articular cartilage from the restrained knee compared with the contralateral control knee. After 3 weeks of immobilization, proteoglycan aggregation was no longer demonstrable in cartilage from the constrained limb. The aggregation defect was rapidly reversible and aggregates were again normal size 2 weeks after removal of a cast that had been worn for 6 weeks.In normal articular cartilage most of the proteoglycans (PG) exist in large aggregates that are noncovalently linked to hyaluronic acid (HA) (1). In osteoarthritis (OA) an aggregation defect exists within the tissue, since a greater than normal proportion of the PGs is not aggregated and aggregates which are present tend to be smaller than normal (2-5).Aggregation defects similar to those of OA in

show abstract

Section: Discussionsupporting

confidence: 56%

Development and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization

Palmoski

Perricone

Brandt

1979

Arthritis & Rheumatism

282

131

View full text Add to dashboard Cite

show abstract

“…It has been suggested that collagen may attract more water and be a more effective gel-former than proteoglycan (Mankin & Thrasher 1975). In addition, newly formed collagen, prior to the development of cross links, may more avidly bind water molecules.…”

Section: Discussionmentioning

confidence: 99%

The Biochemical Response of Rabbit Articular Cartilage Matrix to an Induced Talcum Synovitis

Gershuni¹,

Amiel²,

Gonsalves

et al. 1981

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

“…While there is a strong influence of hydrodynamic effects during fast cyclic compression, in the static case we find a more balanced biomechanical system. Many authors report that MRI visualization changes under pressure (10,(31)(32)(33)(34)(35)(36)(37)(38). It is evident that collagen network structure is influenced by load.…”

Section: Influence Of Load On the Mri Visualization Of Joint Cartilagementioning

confidence: 99%

MRI assessment of cartilage ultrastructure

Gründer¹

2006

NMR in Biomedicine

121

View full text Add to dashboard Cite

In T 2 -weighted MRI images joint cartilage can appear laminated. The multilaminar appearance is visualized as zones of different intensity. This appearance is based on the dipolar interaction of water molecules within cartilage zones of different collageneous network structures. Therefore, the MR visualization of zones of anisotropic arrangement of the collagen fibers depends upon their orientation to the static magnetic field (magic-angle effect). The aim of this article is to demonstrate the potential of high-resolution MRI for characterizing cartilage network structuring and biomechanical properties. Information equivalent to that from polarization light microscopy can be derived noninvasively. Based on NMR microscopic (mMRI) data, potential new possibilities of MRI for quantitative assessment of collagen structuring and intracartilagenous load distribution are presented. These methods use MR intensity angle dependence and load influence on cartilage visualization. Alternatively to the determination of mechanical parameters from cartilage deformation, it is demonstrated that stress distribution and biomechanical properties can be derived in principle from the local intensity variation of anisotropic fiber orientation zones. The limitations with respect to a clinical application of the proposed methods are discussed.

show abstract

Water content and binding in normal and osteoarthritic human cartilage

Cited by 190 publications

References 0 publications

Development and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization

Development and Reversal of a Proteoglycan Aggregation Defect In Normal Canine Knee Cartilage After Immobilization

The Biochemical Response of Rabbit Articular Cartilage Matrix to an Induced Talcum Synovitis

MRI assessment of cartilage ultrastructure

Contact Info

Product

Resources

About