The Biochemical Response of Rabbit Articular Cartilage Matrix to an Induced Talcum Synovitis

Gershuni, David H.; Amiel, David; Gonsalves, Mary; Akeson, Wayne H.

doi:10.3109/17453678108992154

Cited by 17 publications

(10 citation statements)

References 19 publications

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“…This is in accordance with the histological findings of A d a m (1963) of vascular proliferation in the acetabular part of the joint following experimental synovitis. It also agrees with the findings of acetabular cartilage hypertrophy following experimental synovitis (Gershuni et al 1974, Gershuni et al 1981 or following transient synovitis as demonstrated by acetabular roof overgrowth on conventional radiographic follow-up in this study, a phenomenon that has also been demonstrated in manifest Perthes disease (Danielsson et al 1982a, Yngve & Roberts 1985.…”

Section: %Tc-mdp Scintimetrysupporting

confidence: 93%

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Transient Synovitis of the Hip in the Child

Wingstrand¹

1986

Acta Orthopaedica Scandinavica

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Section: %Tc-mdp Scintimetrysupporting

confidence: 93%

“…Experimentally induced hip joint synovitis in the immature rabbit (Gershuni et al 1981) has indicated that joint cartilage responds rapidly to synovitis with increased thickness due to increased hydration and, at a later stage, due to increased metabolism and synthesis.…”

Section: Proteoglycan Fragments In Joint Fluidmentioning

confidence: 99%

Transient Synovitis of the Hip in the Child

Wingstrand¹

1986

Acta Orthopaedica Scandinavica

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“…In the follow-up examinations the increase in joint space, metaphyseal width and acetabular roof width cannot be explained by positional inadvertences as the symphysis did not deviate more than 5 mm from the sagittal plane and as there were not consequently abducted hips on follow-up in these patients. The explanation for the increased values on the affected side should be the increased metabolism and subsequent cartilage production that occurs after synovitis (9).…”

Section: Discussionmentioning

confidence: 99%

Conventional Radiography in Transient Synovitis of the Hip in Children

Egund¹,

Hasegawa²,

Pettersson³

et al. 1987

Acta Radiol

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Conventional radiography was performed at diagnosis and at follow-up 5 to 9 months later in 70 children with transient synovitis of the hip. Twenty-four of the patients also had CT examination at diagnosis. The cartilaginous and osseous reaction in the conventional antero-posterior radiographs was studied as was the relation between the radiographic and CT findings concerning fat planes, joint effusion, and position of the hip joint. At diagnosis there was significant increase in the medial joint space and at follow-up examination there was significant increase in medial and cranial joint space, metaphyseal width and acetabular roof width. There was a correlation of a bulging lateral 'capsular fat plane' to the position of abduction in the affected hip which explains the asymmetry in the lateral fat plane observed in these patients.

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“…Although the effects of arthrotomy on cartilage metabolism have been well documented (1 1,23, 26,40,42,43,[54][55][56]65), there has been limited (27,39,46,68,86) recognition that violation of the synovial membrane by IA injections may also be deleterious to the short term (<14 days) integrity of matrix PGs.…”

Section: Discussionmentioning

confidence: 99%

“…Although an early report by Key (46) that multiple IA iajections of sterile saline into rabbit joints produced arthritic-like changes has been re-cently substantiated (27,68,81,86), the effects of such treatment on proteoglycan (PG) aggregation in articular cartilage have not been previously described. In this paper we report the results of our studies on PG aggregation and release in culture from articular cartilage of rabbit knee joints following one, two, or three consecutive IA injections of sterile saline.…”

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confidence: 99%

Microinjury to the synovial membrane may cause disaggregation of proteoglycans in rabbit knee joint articular cartilage

Frost

Ghosh

1984

Journal Orthopaedic Research

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Proteoglycans (PGs) isolated from articular cartilage (AC) of mature rabbits subjected to two or more consecutive intraarticular (IA) injections of sterile saline 24 h apart showed an aggregation defect in the presence of excess hyaluronic acid (HA). Although the PG contents of experimental and control cartilages were indistinguishable, a higher proportion of PGs were extractable from the 3 X IA tissues, as assessed by uronic acid analysis. Proteoglycans from experimental and control cartilages when examined by Sepharose CL-2B chromatography showed two subunit populations, the smaller (KAV = 0.70) containing more ketatan sulphate than the larger (KAV = 0.31). Cultures of AC from IA joints released more 35SO4-labelled PGs into the media over 72 h than control tissues and consisted mainly of PG degradation products although 20% could aggregate in the presence of HA. Examination of PG aggregation 2 weeks after 2 X IA or 3 X IA injections showed that the defect initiated was still present; however, cartilage of immature rabbits was not affected by the 2 X IA procedure.

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The Biochemical Response of Rabbit Articular Cartilage Matrix to an Induced Talcum Synovitis

Cited by 17 publications

References 19 publications

Transient Synovitis of the Hip in the Child

Transient Synovitis of the Hip in the Child

Conventional Radiography in Transient Synovitis of the Hip in Children

Microinjury to the synovial membrane may cause disaggregation of proteoglycans in rabbit knee joint articular cartilage

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