Water‐compatible molecularly imprinted polymer as a sorbent for the selective extraction and purification of adefovir from human serum and urine

Pourfarzib, Mojgan; Dinarvand, Rasoul; Akbari‐adergani, Behrouz; Mehramizi, Ali; Rastegar, Hossein; Shekarchi, Mohammad

doi:10.1002/jssc.201401492

Cited by 19 publications

(9 citation statements)

References 32 publications

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“…Generally, the samples are pretreated using liquid–liquid extraction (LLE) or solid-phase extraction (SPE). SPE is the currently dominating technique for the extraction of a target compound from different samples including food, environment, and pharmaceutical and biological samples [12] , [13] , [14] . Compared with LLE, SPE is simple and fast, and less solvent consumption.…”

Section: Introductionmentioning

confidence: 99%

A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples

Luo

et al. 2016

Journal of Pharmaceutical Analysis

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Surface molecularly imprinted polymers (SMIPs) for selective adsorption of ampicillin sodium were synthesized using surface molecular imprinting technique with silica gel as a support. The physical and morphological characteristics of the polymers were investigated by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), elemental analysis and nitrogen adsorption–desorption test. The obtained results showed that the SMIPs displayed great adsorption capacity (13.5 μg/mg), high recognition ability (the imprinted factor is 3.2) and good binding kinetics for ampicillin sodium. Finally, as solid phase extraction adsorbents, the SMIPs coupled with HPLC method were validated and applied for the enrichment, purification and determination of ampicillin sodium in real milk and blood samples. The averages of spiked accuracy ranged from 92.1% to 107.6%. The relative standard deviations of intra- and inter-day precisions were less than 4.6%. This study provides a new and promising method for enriching, extracting and determining ampicillin sodium in complex biological samples.

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Section: Introductionmentioning

confidence: 99%

A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples

Luo

et al. 2016

Journal of Pharmaceutical Analysis

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“…333 Hence, the optimized MISPE method should be based on the properties of MIPs, the interaction between MIPs and analytes, and the appropriate solvents used in the extraction procedure. Owing to the high selectivity of MIPs for the template molecule and its structural analogues, MISPE methods have already been applied in environmental, 334- 350 and matrix solid phase dispersion (MSPD).…”

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confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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“…Due to their excellent molecular recognition capability and chemical and mechanical stability, MIPs are more and more investigated for extraction and determination of compounds in various samples with different techniques . Recently, members of our research group applied MIPs as off‐line SPE where the MIP is equilibrated with sample for some important medicinal molecules in pharmaceuticals and biological fluids and on‐line extractions where the MIPs are filled into columns or cartridges . With the aim of using the benefits of membrane as extraction media, we also used MIPs for extraction of hippuric acid with MIP polysulfone membrane and l ‐tyrosine as a lung cancer biomarker with an MIP‐modified polysulfone membrane .…”

Section: Introductionmentioning

confidence: 99%

Integrated photografted molecularly imprinted polymers with a cellulose acetate membrane for the extraction of melamine from dry milk before HPLC analysis

et al. 2017

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In this study, a new separation technique based on membrane extraction is described for the determination of melamine in dry milk. The water-compatible cellulose acetate membrane, which is photografted by melamine imprinted nanospheres, was prepared by placing the membrane into the polymerization solution containing methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as cross-linker, acetonitrile as porogen, and melamine as the template molecule. The characterization of the polymeric membrane was performed by Fourier transmission infrared spectroscopy and scanning electron microscopy. This integrated composite membrane was used as a solid-phase extraction medium for the extraction of melamine from dry milk samples. Various parameters affecting the extraction efficiency of the membrane were evaluated. The results showed higher binding capacity for melamine imprinted membranes in comparison with the nonimprinted membranes. High-performance liquid chromatography analysis showed that the extraction of melamine from dry milk by the photografted cellulose acetate membrane had a linear calibration curve in the range of 0.02-11.80 μg/mL with an excellent precision of 2.73%. The limit of detection and quantification of melamine was 0.007 and 0.020 μg/mL, respectively. The recoveries of melamine were in the range of 88.7-94.8%.

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Water‐compatible molecularly imprinted polymer as a sorbent for the selective extraction and purification of adefovir from human serum and urine

Cited by 19 publications

References 32 publications

A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples

A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples

Molecular imprinting: perspectives and applications

Integrated photografted molecularly imprinted polymers with a cellulose acetate membrane for the extraction of melamine from dry milk before HPLC analysis

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