A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples

Wu, Ningli; Luo, Zhimin; Ge, Yanhui; Guo, Pengqi; Du, Kangli; Tang, Weibing; Du, Wei; Zeng, Aiguo; Chang, Chun; Fu, Qiang

doi:10.1016/j.jpha.2016.01.004

Cited by 62 publications

(14 citation statements)

References 29 publications

(30 reference statements)

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“…In addition, because of desirable magnetic properties (15 emu/g), it is easier to separate sorbent from sample and realize recycling than nonmagnetic MOF. From the analytical aspect, the linear range and LOD of the proposed method were approximately the same or better than those of some other methods, which represents the promising future of our present MMOF for determination of AMP from complicated cow milk samples [ 3 , [41] , [42] , [43] ] ( Table 3 ). Moreover, the prepared MMOF was compared with some commercial sorbents presented in Table 4 [ [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] ].…”

Section: Resultsmentioning

confidence: 72%

Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

Bagheri

Ghaedi

2020

Journal of Pharmaceutical Analysis

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The aim of this study is a present of a simple solvothermal synthesis approach to preparation of Cu-based magnetic metal organic framework (MMOF) and subsequently its application as sorbent for ultrasound assisted magnetic solid phase extraction (UAMSPE) of ampicillin (AMP) from cow milk samples prior to high performance liquid chromatography-Ultraviolet (HPLC-UV) determination. Characteristics of prepared MMOF were fully investigated by different techniques which showed the exclusive properties of proposed sorbent in terms of proper functionality, desirable magnetic property and also high specific surface area. Different influential factors on extraction recovery including sorbent dosage, ultrasonic time, washing solvent volume and eluent solvent volume were assessed using central composite design (CCD) based response surface methodology (RSM) as an operative and powerful optimization tool. This is the first report for determination of AMP using MMOF. The proposed method addressed some drawbacks of other methods and sorbents for determination of AMP. The presented method decreases the extraction time (4 min) and also enhances adsorption capacity (250 mg/g). Moreover, the magnetic property of presented sorbent (15 emu/g) accelerates the extraction process which does not need filtration, centrifuge and precipitation procedures. Under the optimized conditions, the proposed method is applicable for linear range of 1.0–5000.0 μg/L with detection limit of 0.29 μg/L, satisfactory recoveries (≥95.0%) and acceptable repeatability (RSD less than 4.0%). The present study indicates highly promising perspectives of MMOF for highly effective analysis of AMP in complicated matrices.

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Section: Resultsmentioning

confidence: 72%

Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

Bagheri

Ghaedi

2020

Journal of Pharmaceutical Analysis

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“…In the case of CLO removal by modified silica particles, Du et al () reported that the maximum adsorption capacity of the particles was 6.5 mg/g per gram of adsorbent. In other studies, Li et al () and Wu et al () reported that one gram of MIP particles synthesised for ampicillin can adsorb 13.5 mg of the antibiotic. Compared to these cases, the polymer particles prepared in this study are much more efficient.…”

Section: Resultsmentioning

confidence: 95%

Synthesis and characterisation of a selective adsorbent based on the molecularly imprinted polymer for the removal of cloxacillin antibiotic residue from milk

Jafari

Dehghani

Nasirizadeh

et al. 2019

Int J of Dairy Tech

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In recent decades, environmental pollution has been a subject of growing concern. This is partly due to the overuse of antibiotics, the consequent drug resistance and the discharge of drugs into the environment. The aim of this study was to synthesise molecularly imprinted polymer (MIP) particles via a noncovalent procedure for the removal of cloxacillin from milk. Accordingly, the effects of operational parameters such as pH, contact time and MIP dosage were studied. The performance of MIP particles in removing cloxacillin from livestock milk samples proved that these adsorbents can effectively help to reduce drug contamination from dairy sources.

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“…However, the Cu‐IIP1 and NIP1 showed the same trend, and the fluctuation bar graphs might be the low concentration of HPMC occurred hydrogen bonding with methacrylic acid and produced the random cavity in the polymer . The adsorption amount of Cu‐IIPs toward Cu 2+ ions immediately increased with the increase of the concentrations of Cu 2+ solution in the initial concentration resulting from the recognition cavities during the imprinting process …”

Section: Resultsmentioning

confidence: 99%

Synthesis of copper(II) ion‐imprinted polymers via suspension polymerization

Chaipuang

Phungpanya

Thongpoon

et al. 2018

Polymers for Advanced Techs

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Funding informationScience Achievement Scholarship of Thailand (SAST); Mae Fah Luang University (MFU) Copper(II) (Cu 2+ ) ion-imprinted polymers were prepared by suspension polymerization using 2.5 mmol of copper(II) sulfate pentahydrate as the template ion, 5 mmol of 4-vinylpyridine and methacrylic acid as functional monomers, 20 mmol of ethylene glycol dimethacrylate as the cross-linker, 1 mmol of 1,1′-azobis (cyclohexanecarbonitrile) as the initiator in the porogen of 10 mL of toluene, and hydroxypropyl methyl cellulose as a stabilizer in the polymerization reaction. The obtained polymers were used to quantify Cu 2+ ion by using flame atomic absorption spectroscopy. Chemical structure, morphology, crystalline structure, and surface area of polymers were investigated by Fourier transform infrared spectroscopy, scanning electron microscope, X-ray diffraction, and Brunauer-Emmett-Teller respectively. The diameters of the synthesized polymer particles were about 250 nm. The Cu 2+ ion-imprinted polymers illustrated good recognition property and selective adsorption ability with Cu 2+ higher than Mn 2+ and Fe 2+ . Thus, this work could be applied as a sorbent from the enrichment of Cu 2+ ions in analytes.

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A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples

Cited by 62 publications

References 29 publications

Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

Synthesis and characterisation of a selective adsorbent based on the molecularly imprinted polymer for the removal of cloxacillin antibiotic residue from milk

Synthesis of copper(II) ion‐imprinted polymers via suspension polymerization

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