Water and electrolyte absorption from hypotonic oral rehydration solution in rat small intestine and colon

Nishinaka, Daisuke; Kishino, Fumiharu; Matsuura, Akihiro

doi:10.1111/j.1442-200x.2004.01887.x

Cited by 20 publications

(25 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4A) was the main determinant of this result. The SD showed a very low rate of water absorption in the small intestine, a result that is similar to that of a previous study (Nishinaka et al 2004). It has been reported that water absorption was delayed when the carbohydrate concentration in an ingested drink was above 6% (Jeukendrup et al, 2009).…”

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Addition of Whey Peptides to a Carbohydrate-electrolyte Drink Enhances its Effect on the Early Treatment of Dehydration in Rats

Ito

Saito

Yamaguchi

et al. 2016

FSTR

View full text Add to dashboard Cite

Previous studies suggested that peptide absorption by peptide transporter 1 (PepT1) contributes to water absorption in the small intestine. Here, we aimed to apply this effect of peptides to a rehydration drink for the effective treatment of dehydration. We first prepared a whey peptide drink (WPD) in which the composition (whey peptides and Na + ) was optimized for water absorption in the small intestine. We then evaluated the effectiveness of the WPD in an in vivo dehydration model. The results demonstrated the following: (1) the addition of whey peptides to a carbohydrate-electrolyte drink enhanced the rehydration effect in the rat dehydration model, i.e., it increased the plasma volume more quickly and more abundantly; and (2) the WPD was more effective for rehydration than a general sports drink. The WPD could be considered a new treatment option for the rapid alleviation of dehydration.

show abstract

Section: Discussionsupporting

confidence: 77%

“…The water absorption rate was measured using the rat small intestine perfusion model described by Nishinaka et al (2004). Briefly, 4-6 rats in each group were anesthetized with urethane (1.5 g/kg, subcutaneously) and then laparotomized.…”

Section: Test Animals and Rearing Conditionsmentioning

confidence: 99%

Addition of Whey Peptides to a Carbohydrate-electrolyte Drink Enhances its Effect on the Early Treatment of Dehydration in Rats

Ito

Saito

Yamaguchi

et al. 2016

FSTR

View full text Add to dashboard Cite

show abstract

“…Ensaios clínicos realizados em crianças e animais de laboratório têm evidenciado resultados superiores na utilização de soluções eletrolíticas enterais hipotônicas, corrigindo os desequilíbrios hidro-eletrolíticos, ácido base e a hipoglicemia mais rapidamente, reduzindo a duração da diarreia e o tempo de internamento dos pacientes (RAUTANEN et al, 1993;NISHINAKA et al, 2004). Em equinos, FARIAS (2010) registrou maior expansão do volume plasmático nos animais tratados com soluções hipotônicas enterais, quando comparados aos tratados com solução isotônica enteral.…”

Section: Introductionunclassified

Soluções eletrolíticas enterais hipotônicas em equinos: efeitos de fontes de energia sobre determinados indicadores do equilíbrio ácido base

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Fecal osmolarity, and fecal score and moisture were greater for PM than WG diets (Table 6). Osmolarity is characterized by solute concentration (fermentation products and electrolytes), and can be responsible for less water absorption from the colon (Nishinaka et al, 2004) and, consequently, increased fecal score and moisture. Greater fecal osmolarity could indicate greater fermentative activity in dogs fed PM diets.…”

Section: Effect Of Protein Sourcementioning

confidence: 99%

Influence of dietary protein content and source on fecal quality, electrolyte concentrations, and osmolarity, and digestibility in dogs differing in body size1

Nery

Biourge

Tournier

et al. 2010

Journal of Animal Science

View full text Add to dashboard Cite

When fed the same diet, large-breed dogs tend to produce feces of poorer quality compared with small-breed dogs. Moreover, German shepherds, although having a BW similar to Giant Schnauzers, are particularly prone to digestive intolerance, producing feces of poor consistency and increased moisture. Digestive tolerance reflects the reaction of the animal to the diet, and it can be assessed by determining fecal quality (consistency, moisture, volume, odor, and color). This study was conducted to assess the effect of protein source and content on fecal quality, and to determine whether greater digestibility and lesser fecal osmolarity and electrolyte concentrations are associated with improved fecal quality in dogs differing in body size and digestive tolerance. Twenty-seven healthy female dogs were divided into 4 groups according to BW and digestive tolerance: small, medium, large tolerant, and large sensitive. Five diets, varying in protein source (wheat gluten, poultry meal, and a 50:50 mixture of both sources) and concentration (22, 29, and 39% CP on a DM basis for low, medium, and high, respectively) were tested. The present study was divided in 2 phases: 2 diets were studied in a crossover design in phase I, and 3 diets were studied in a Latin square design in phase II. Diets were fed for 14 d, followed by a 12-d transition period. Fecal score (1 = dry and hard feces, to 5 = liquid diarrhea), moisture, electrolytes (Na and K), and osmolarity, and digestibility of DM, energy, fat, CP, and ash were determined. Fecal score and moisture (P < 0.001) were less and overall digestibility (P < 0.001 for DM, CP, fat, ash, and energy) was greater for wheat gluten than for poultry meal diets. Large dogs had the greatest fecal score and moisture (P < 0.001), together with the greatest overall digestibility (P < 0.001 for DM, P = 0.054 for CP, P = 0.005 for ash, and P = 0.003 for energy). Osmolarity was less for wheat gluten-based diets (P < 0.001), and was not affected by dog size. Fecal electrolyte concentration varied mainly with dog group (P = 0.005 for Na, and P < 0.001 for K), being greater in large sensitive dogs compared with small dogs. Wheat gluten was proved to be a suitable protein source for modulating fecal quality in dogs, particularly in sensitive breeds. Poorer fecal quality in large sensitive dogs can be related to greater digestibility and greater fecal electrolyte concentrations, but not to fecal osmolarity.

show abstract

Water and electrolyte absorption from hypotonic oral rehydration solution in rat small intestine and colon

Abstract: These data indicate that low osmolality is a crucial factor to facilitate water absorption, and the electrolytes, sodium and chloride, can effectively be salvaged in the colon.

Cited by 20 publications

References 24 publications

Addition of Whey Peptides to a Carbohydrate-electrolyte Drink Enhances its Effect on the Early Treatment of Dehydration in Rats

Addition of Whey Peptides to a Carbohydrate-electrolyte Drink Enhances its Effect on the Early Treatment of Dehydration in Rats

Soluções eletrolíticas enterais hipotônicas em equinos: efeitos de fontes de energia sobre determinados indicadores do equilíbrio ácido base

Influence of dietary protein content and source on fecal quality, electrolyte concentrations, and osmolarity, and digestibility in dogs differing in body size1

Contact Info

Product

Resources

About