Water and Aging

Reiff, Theodore R.

doi:10.1016/s0749-0690(18)30820-6

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…We attribute these findings to the significant differences in colloid osmotic pressure over the course of the study (6). In the HES group, COP increased because the hydroxyethyl starch solution is hyperoncotic for young pigs as it is for infants with lower protein levels and an altered ratio of extracellular fluid volume to total body water compared with adults (7–9). Therefore, isooncotic synthetic colloid solutions for adults are hyperoncotic for infants (10) and the observed haemodilution in the HES group may be due to plasma volume expansion caused by transcapillary fluid shifts from the interstitial space into the intravascular space.…”

Section: Discussionmentioning

confidence: 99%

Haemodynamic, acid–base and electrolyte changes during plasma replacement with hydroxyethyl starch or crystalloid solution in young pigs

Sümpelmann

Schürholz

Marx

et al. 2000

Pediatric Anesthesia

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We investigated haemodynamic, acid-base and electrolyte changes during almost total plasma replacement with hydroxyethyl starch (HES) and physiological balanced electrolyte solution (PBE) by using a cell saver in ten young pigs. In the PBE group an additional 3550 (444) ml crystalloid solution [Mean (SD)] was infused over the course of the study in order to maintain pulmonary capillary wedge pressure. Plasma protein levels decreased in both groups and the colloid osmotic pressure increased in HES and decreased in PBE. At the end of the study, body weight [HES 10.4 (1), PBE 13.1 (1.4) kg, P < 0.01] and lactic acid concentration [HES 0.9 (0.3), PBE 2.9 (1. 3) mmol.l -1, P < 0.01] was higher and tissue oxygen delivery [HES 327 (22), PBE 89 (29) ml.min.m2, P < 0.01] was lower in the PBE group. There were only moderate acid-base changes in both groups, but at the end, anion gap was significant lower in HES. In conclusion, maintenance of colloid osmotic pressure close to the physiological range of infants seems to be advantageous during major paediatric surgery.

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Section: Discussionmentioning

confidence: 99%