Water Aerosols and Cough

Fontana, Giovanni; Lavorini, Federico

doi:10.1006/pupt.2002.0359

Cited by 31 publications

(13 citation statements)

References 30 publications

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“…Detecting that without food the cough reflex was found in all of the patients leads to think that cough is a relevant defense mechanism and it works to remover mucus and strange bodies of the upper airways (9), and cough sensitivity is impaired in advanced-stage PD (8). PD's evolving degree and the individual's age reduce the ability of respiratory muscular activity and the expiratory strength, resulting in a weak reflex response or absent (8,9). By finding 84.2% of reflex responses of non-food cough in an area of vestibular folds in the study group, this study agrees (13) that the receptors of laryngeal cough reflexes are found in the supraglottic membrane.…”

Section: Discussionmentioning

confidence: 99%

“…The function of cough reflex (CR) is to remove secretion and/or a strange body from the airways, causing an important expiratory flux in the defense against pneumonia by aspiration (8,9). The parkinsonian symptoms and PD evolution are relevant to the inefficiency of the oropharyngeal mechanisms of deglutition, breathing, phonation and protective reflexes of the lower airways.…”

Section: Iintroductionmentioning

confidence: 99%

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Deglutition and Cough in Different Degrees of Parkinson Disease

Gasparim¹,

Jurkiewicz

Marques

et al. 2011

Arquivos Internacionais de Otorrinolaringologia

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Summary Introduction: Parkinson disease is one of the pathologies mostly affecting deglutition. Objective: To analyze the efficiency of both deglutition and cough reflex in cases of laryngeal penetration or tracheal aspiration with food, in different severity stages of Parkinson disease. Study's way: contemporaneous cohort with transverse incision. Method: The sample had 38 patients in the study group and 38 individuals in the control group submitted to a neurologic evaluation and an otorhinolaryngological evaluation by transnasal fiberoptic laryngoscopy. Results: The cough reflex was manifested in 100% of patients without food offering. Alimentary stasis in piriform recesses and epiglottic vallecula in solid, pasty and liquid consistency was significant (p= 0.0000). The laryngeal penetration in liquid consistency was significant (p= 0.0036). Tracheal aspiration occurred in 06 patients of the study group in liquid consistency and it was absent in control group. Conclusion: The efficiency of deglutition in the study group prevailed in the solid consistency, followed by pasty and liquid consistencies. In the control group, deglutition was effective in all individuals. Cough reflex was efficient in most patients of the study group and prevalently inefficient in the subgroup 2.

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Section: Discussionmentioning

confidence: 99%

Section: Iintroductionmentioning

confidence: 99%

Deglutition and Cough in Different Degrees of Parkinson Disease

Gasparim¹,

Jurkiewicz

Marques

et al. 2011

Arquivos Internacionais de Otorrinolaringologia

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“…37 Mast cell stabilisers Cromoglycate and nedocromil (commonly grouped together as cromones) are attractive medications for non-specific cough as these medications are much less likely to cause significant side effects than inhaled corticosteroids. Nedocromil and cromoglycate increase cough threshold 38 and reduce neurogenic inflammation which is believed to be the most important peripheral inflammation process involved in human cough. 20 39 However, a Cochrane systemic review found no RCT that examined the efficacy of inhaled cromones in the management of prolonged non-specific cough in children.…”

Section: Inhaled B2-agonistsmentioning

confidence: 99%

Management of chronic non-specific cough in childhood: an evidence-based review

Gupta¹,

McKean²,

Chang³

2007

Archives of Disease in Childhood - Education and Practice

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“…Studies in experimental animals and in humans show clearly that multiple types of mechanical and chemical stimuli can (under the right experimental conditions) evoke coughing [1,12,24-30,37,38]. This would argue that multiple afferent nerve subtypes (mechanosensors and chemosensors) might be involved in the production of reflex coughing.…”

Section: Introductionmentioning

confidence: 99%

An overview of the sensory receptors regulating cough

Mazzone

2005

Cough

128

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The cough reflex represents a primary defensive mechanism for airway protection in a variety of mammalian species. However, excessive and inappropriate coughing can emerge as a primary presenting symptom of many airway diseases. Cough disorders are characterized by a reduction in the threshold for reflex initiation and, as a consequence, the occurrence of cough in response to stimuli that are normally innocuous in nature. The current therapeutic strategies for the treatment of cough disorders are only moderately effective. This undoubtedly relates in part to limitations in our understanding of the neural components comprising the cough reflex pathway. The aim of this review is to provide an overview of current concepts relating to the sensory innervation to the mammalian airways, focusing particularly on the sensory receptors that regulate cough. In addition, the review will highlight particular areas and issues relating to cough neurobiology that are creating controversy in the field.

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Water Aerosols and Cough

Cited by 31 publications

References 30 publications

Deglutition and Cough in Different Degrees of Parkinson Disease

Deglutition and Cough in Different Degrees of Parkinson Disease

Management of chronic non-specific cough in childhood: an evidence-based review

An overview of the sensory receptors regulating cough

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