Was hilft wirklich bei tumorbedingter Fatigue? Ein Überblick über systematische Übersichtsarbeiten

Reif, Karl; Vries, U. de; Petermann, Fanny

doi:10.1024/1012-5302/a000246

Cited by 11 publications

(4 citation statements)

References 30 publications

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“…CRF can be difficult to manage; pharmacological solutions have limited effect and there has been a call for non-pharmacological interventions [ 7 ]. Physical activity [ 8 ], cognitive behaviour therapy and psychosocial support [ 9 ] may improve CRF, but existing programmes are not accessible to many and often require significant input from trained professionals to deliver them.…”

Section: Introductionmentioning

confidence: 99%

A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial

Foster

Grimmett

May

et al. 2015

Support Care Cancer

216

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PurposeCancer-related fatigue (CRF) is a frequent and distressing symptom experienced after cancer treatment. RESTORE is the first web-based resource designed to enhance self-efficacy to manage CRF following curative-intent treatment. The aim of this study is to test the proof of concept and inform the design of an effectiveness trial.MethodsA multi-centre parallel-group two-armed (1:1) exploratory randomised controlled trial (RCT) with qualitative process evaluation was employed in the study. Participants (≥18 years; ≤5 years post treatment with moderate to severe fatigue) were recruited and randomly assigned to RESTORE or a leaflet. Feasibility and acceptability were measured by recruitment, attrition, intervention adherence, completion of outcome measures and process evaluation. Change in self-efficacy to manage CRF was also explored. Outcome measures were completed at baseline (T0), 6 weeks (T1) and 12 weeks (T2). Data were analysed using mixed-effects linear regression and directed content analysis.ResultsOne hundred and sixty-three people participated in the trial and 19 in the process evaluation. The intervention was feasible (39 % of eligible patients consented) and acceptable (attrition rate 36 %). There was evidence of higher fatigue self-efficacy at T1 in the intervention group vs comparator (mean difference 0.51 [−0.08 to 1.11]), though the difference in groups decreased by 12 weeks. Time since diagnosis influenced perceived usefulness of the intervention. Modifications were suggested.ConclusionProof of concept was achieved. The RESTORE intervention should be subject to a definitive trial with some adjustments. Provision of an effective supportive resource would empower cancer survivors to manage CRF after treatment completion.Trial registrationISRCTN67521059

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Section: Introductionmentioning

confidence: 99%

A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial

Foster

Grimmett

May

et al. 2015

Support Care Cancer

216

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show abstract

“…CRF is one the most common and distressing symptoms experienced by people affected by cancer with no known effective pharmacological treatment [ 8 ]. There is growing support for physical activity [ 9 ] and interventions that include psychosocial support and cognitive behaviour therapy in improving CRF [ 10 ], however access to existing programmes is limited and such programmes are, most often, resource intensive.…”

Section: Introductionmentioning

confidence: 99%

RESTORE: an exploratory trial of a web-based intervention to enhance self-management of cancer-related fatigue: findings from a qualitative process evaluation

Myall

May

Grimmett

et al. 2015

BMC Med Inform Decis Mak

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BackgroundCancer-related fatigue is a distressing symptom experienced by many after cancer treatment. An exploratory randomised controlled trial was conducted to test proof of concept of RESTORE: a web-based tool to enhance self-efficacy to manage cancer-related fatigue. This paper reports findings from a qualitative process evaluation to determine feasibility and acceptability of the intervention and trial processes.MethodQualitative process evaluation carried out at the end of the trial to explore participants’ experiences using semi-structured telephone interviews with a purposive sample of participants from both trial arms. Normalisation Process Theory informed data collection and analysis. Analysis involved directed content analysis within a Framework Approach.ResultsNineteen participants took part. They understood the purpose and requirements of the trial and identified beneficial outcomes from taking part. For the majority, the work of the trial was easily accommodated into daily routines and did not require new skills. There were mixed views about the value of the information provided by RESTORE, depending on time since diagnosis and treatment. Personal factors, constraints of the intervention, and environmental context inhibited the integration and embedding of RESTORE into everyday life. Access to the intervention at an early stage in the treatment trajectory was important to effective utilisation, as were individual preferences for delivery of information.ConclusionThe theoretical foundations of the intervention were sound. Participants derived benefits from the intervention but barriers to implementation and integration suggest that RESTORE and the trial processes require some modification before testing in a full trial.Trial registrationISRCTN67521059 (10th October 2012).Electronic supplementary materialThe online version of this article (doi:10.1186/s12911-015-0214-y) contains supplementary material, which is available to authorized users.

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“…To ensure that a comprehensive description of all aspects of the intervention was provided, content was also described with reference to the CBT competence framework for working with people with persistent physical health conditions [53]. We then summarized each of the intervention sessions and their association with the CBT [53], and the self-regulation model [54,55] constructs targeted and the BCTs used [14]. …”

Section: Methodsmentioning

confidence: 99%

Cancer-Related Fatigue in Post-Treatment Cancer Survivors: Theory-Based Development of a Web-Based Intervention

Corbett¹,

Walsh²,

Groarke³

et al. 2017

JMIR Cancer

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BackgroundCancer-related fatigue (CrF) is the most common and disruptive symptom experienced by cancer survivors. We aimed to develop a theory-based, interactive Web-based intervention designed to facilitate self-management and enhance coping with CrF following cancer treatment.ObjectiveThe aim of our study was to outline the rationale, decision-making processes, methods, and findings which led to the development of a Web-based intervention to be tested in a feasibility trial. This paper outlines the process and method of development of the intervention.MethodsAn extensive review of the literature and qualitative research was conducted to establish a therapeutic approach for this intervention, based on theory. The psychological principles used in the development process are outlined, and we also clarify hypothesized causal mechanisms. We describe decision-making processes involved in the development of the content of the intervention, input from the target patient group and stakeholders, the design of the website features, and the initial user testing of the website.ResultsThe cocreation of the intervention with the experts and service users allowed the design team to ensure that an acceptable intervention was developed. This evidence-based Web-based program is the ﬁrst intervention of its kind based on self-regulation model theory, with the primary aim of targeting the representations of fatigue and enhancing self-management of CrF, speciﬁcally.ConclusionsThis research sought to integrate psychological theory, existing evidence of effective interventions, empirically derived principles of Web design, and the views of potential users into the systematic planning and design of the intervention of an easy-to-use website for cancer survivors.

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Was hilft wirklich bei tumorbedingter Fatigue? Ein Überblick über systematische Übersichtsarbeiten

Cited by 11 publications

References 30 publications

A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial

A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial

RESTORE: an exploratory trial of a web-based intervention to enhance self-management of cancer-related fatigue: findings from a qualitative process evaluation

Cancer-Related Fatigue in Post-Treatment Cancer Survivors: Theory-Based Development of a Web-Based Intervention

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