Warthin's tumor: A hypersensitivity disease?

Allegra, Salvatore R.

doi:10.1016/s0046-8177(71)80007-2

Cited by 121 publications

(18 citation statements)

References 26 publications

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“…Small foci of oncocytic metaplasia and periductal lymphocytic infiltration are not uncommon adjacent to parotid adenolymphomas (Whittaker, 1972), and it seems to us that the mechanism described by Veronesi and Corbetta (1960) and Allegra (1971) may well explain some cases. We also believe, however, that most cases, particularly in the parotid area, do arise from salivary duct inclusions within lymph nodes and that the theories are not mutually exclusive.…”

Section: Discussionmentioning

confidence: 94%

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Papillary tumours of the minor salivary glands.

Whittaker¹,

Turner²

1976

J Clin Pathol

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The clinical and histological features of oncocytic adenomatous hyperplasia, papillary adenoma, and papillary adenocarcinoma of the oral cavity are described, and the literature is reviewed. Histological features which may be of value in distinguishing between benign and malignant variants are described, and in view of the slow growth rate of most of these tumours, the importance of long-term follow-up is stressed.

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Section: Discussionmentioning

confidence: 94%

“…A more recent paper (Allegra, 1971) advances a similar theory for the histogenesis of adenolymphoma based on light, fluorescent, and electron microscopic studies and suggests that the tissue reaction may be of the delayed hypersensitivity type.…”

Section: Discussionmentioning

confidence: 95%

Papillary tumours of the minor salivary glands.

Whittaker¹,

Turner²

1976

J Clin Pathol

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“…One opinion is that FDG accumulates in the physiological lymphoid element, similarly to polyclonal tonsillar tissue. 8 •" The other is that FDG may accumulate in the active infiltrated lymphocytes, 16,11 similarly to Hashimoto's thyroiditis. Although FDG accumulates in these patients, 19 '2° it is unlikely that Hashimoto's thyroiditis and Warthin's tumor have similar pathophysiologic characteristic.…”

Section: '°'13mentioning

confidence: 99%

Four cases of Warthin’s tumor of the parotid gland detected with FDG PET

Horiuchi

Yasuda²,

Shohtsu³

et al. 1998

Ann Nucl Med

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In the cancer screening with FDG PET for 1,872 medical health club members, high FDG accumulation in the parotid gland was found in four males (age, 57-70 years). Warthin's tumor was confirmed by surgical pathology. The exact mechanism of high FDG accumulation in Warthin's tumor is not yet known. This tumor may be found incidentally during FDG PET studies. When high FDG accumulation is found in the parotid gland, integrated consideration of the results of the physical examination, medical history and 99mTc-pertechnetate scintigraphy makes it possible to differentiate Warthin's tumor from other lesions.

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“…B lymphocytes and T lymphocytes are the main cell components of the lymphoid stroma of War-Ts [5, 6]. The tumor characteristics of War-T have been investigated in many studies.…”

Section: Introductionmentioning

confidence: 99%

Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor

Takizawa

Hayasaka

et al. 2014

Anal Bioanal Chem

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Warthin tumor (War-T), the second most common benign salivary gland tumor, consists mainly of neoplastic epithelium and lymphoid stroma. Some proteins and genes thought to be involved in War-T were evaluated by molecular biology and immunology. However, lipids as an important component of many tumor cells have not been well studied in War-T. To elucidate the molecular biology and pathogenesis of War-T, we investigated the visualized distribution of phosphatidylcholines (PCs) by imaging mass spectrometry (IMS). In our IMS analysis of a typical case, 10 signals were significantly different in intensity (p < 0.01) between the War-T and non-tumor (Non-T) regions. Five specific PCs were frequently found in the War-T regions of all of the samples: [PC (16:0/16:0) + K]+ (m/z 772.5), [PC (16:0/20:4) + K]+ (m/z 820.5), [PC (16:0/20:3) + K]+ (m/z 822.5), [PC (18:2/20:4) + K]+ (m/z 844.5), and [PC (18:0/20:5) + K]+ (m/z 846.5). PC (16:0/16:0) was increased specifically in the folliculus lymphaticus of War-T lymphoid stroma, suggesting a different metabolism. Localization of PC (16:0/16:0) might reflect inflammation activity participating in the pathogenesis of War-T. Thus, our IMS analysis revealed the profile of PCs specific to the War-T region. The molecules identified in our study provide important information for further studies of War-T pathogenesis.

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Warthin's tumor: A hypersensitivity disease?

Cited by 121 publications

References 26 publications

Papillary tumours of the minor salivary glands.

Papillary tumours of the minor salivary glands.

Four cases of Warthin’s tumor of the parotid gland detected with FDG PET

Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor

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