Wann ist eine Tetanie mit A. T. 10 zu behandeln?

Holtz, F.

doi:10.1055/s-0028-1130293

Cited by 21 publications

(6 citation statements)

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“…Skin changes occur with alopecia and eczema (Schmidt-La Baume, 1937). Particularly unfortunate may be the ectodermal changes which result in cataract (Holtz, 1934;Lachmann, 1941), and which have been known to appear as early as 6 months postoperatively (Dent and Friedman, 1964). Fits and convulsions can be the presenting symptom (retch, 1963) and may simulate intracranial growths.…”

Section: Non-coxmentioning

confidence: 99%

Thyroidectomy and the parathyroids

Michie

Stowers

Frazer

et al. 1965

British Journal of Surgery

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Section: Non-coxmentioning

confidence: 99%

Thyroidectomy and the parathyroids

Michie

Stowers

Frazer

et al. 1965

British Journal of Surgery

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“…Long before the metabolism of vitamin D and its regulation was elucidated, dihydrotachysterol was reported to be a useful substitute for the natural vitamin D in hypoparathyroidism (Holtz 1934). The compound is usually administered as a mixture of irradiated sterols, standardized biologically.…”

Section: Resultsmentioning

confidence: 98%

Comparison Between the 5,6-Cis and 5,6-Trans Isomers of 25-Hydroxyvitamin D3 in Chronic Hypoparathyroidism

Offermann

Kraft

1977

Acta Endocrinologica

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Five patients with chronic post-operative hypoparathyroidism were treated with 450 \g=m\g/day5,6-trans-25-hydroxyvitamin D3 (5,6-trans-25OHD3) for 14 days, and the treatment was continued with 150 \g=m\g/day for one year. At the end of this period the patients received 450 \g=m\g/day 5,6-cis-25\x=req-\ hydroxyvitamin D3 (5,6-cis-25OHD3) for 14 days. Comparison of the effects of both isomers revealed a similar ability to enhance intestinal calcium absorption and to normalize serum calcium; serum phosphate and alkaline phosphatase, however, remained unaffected. Urinary phosphate and hydroxyproline excretion decreased on the cis-isomer and increased on the trans-isomer. During treatment with the lower dose of 5,6-trans\x=req-\ 25OHD3 intestinal calcium absorption remained in the normal range for one year, whereas the serum calcium decreased to the levels observed before administration of 450 \g=m\g/day within 6 weeks. The results suggest that in hypoparathyroidism 5,6-cis-25OHD3 and 5,6-trans-25OHD3 are equally effective on serum calcium and on intestinal calcium absorption, but that their mode of action on renal phosphate handling and on calcium release from bone is different. Treatment of hypocalcaemia in hypoparathyroidism requires pharmacological doses of vitamin D (Ireland et al. 1968). The refractoriness to the actions of vitamin D has been found to be due to an impaired conversion of the vitamin to its metabolically active form in this condition (Kooh et al. 1975; Russell et al. 1974). Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D3.In a second step this metabolite undergoes renal conversion to 1,25-dihydroxyvitamin D3, the active form of the vitamin. The renal production of 1,25-di-

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“…These patients are prone to cataract formation and mental changes, particularly if the serum calcium remains below 7.5 mg. per IOO ml. for any length of time, and indeed cataracts have been reported to develop within a few months of thyroidectomy (Holtz, 1934;Dent and Friedman, 1964). It is of great importance, therefore, to follow up all patients who have had overt symptoms after operation, even when they are symptom-free, in order to ensure that the serum-calcium level either returns to normal or is kept within normal limits by suitable replacement therapy.…”

Section: Postoperative Parathyroidmentioning

confidence: 99%

Three major complications of thyroidectomy

Wade

1965

British Journal of Surgery

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Wann ist eine Tetanie mit A. T. 10 zu behandeln?

Cited by 21 publications

References 0 publications

Thyroidectomy and the parathyroids

Thyroidectomy and the parathyroids

Comparison Between the 5,6-Cis and 5,6-Trans Isomers of 25-Hydroxyvitamin D3 in Chronic Hypoparathyroidism

Three major complications of thyroidectomy

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