Walnut (Juglans regia) leaf extracts are strong scavengers of pro-oxidant reactive species

Almeida, Isabel F.; Fernandes, Eduarda; Lima, José L.F.C.; Costa, Paulo; Bahia, Maria Fernanda

doi:10.1016/j.foodchem.2007.07.017

Cited by 103 publications

(79 citation statements)

References 37 publications

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“…Vismia cauliflora extracts demonstrated high capacity to scavenge ONOO À and all parts presented IC 50 values lower than 5.8 mg/mL (without NaHCO 3 ) and 9.8 mg/mL (in the presence of 25 mM NaHCO 3 ) ( Table 3). The flower and stem bark extracts of V. cauliflora exhibit slight higher efficiency than Juglans regia leaf extract (1.66 mg/mL), a plant used in folk medicine for the treatment of several disorders as skin inflammations and ulcers (Almeida et al, 2008b).…”

Section: Scavenging Of Ros and Rns By Vismia Cauliflora Extractsmentioning

confidence: 96%

“…Therefore, the extracts that are able to eliminate hydrogen peroxide may be significant for human health and have the potential to be used to protect pharmaceutical and food system (Sen et al, 2013). Concerning the scavenging capacity of V. cauliflora against H 2 O 2 , the flower extract was more effective than all other parts and also showed higher efficiency than standards of gallic acid, quercetin, ascorbic acid (Table 3), ellagic acid (108.3 mg/mL) , Juglans regia leaf extracts (383 mg/mL) (Almeida et al, 2008b), and Meyna spinosa leaf extracts, a traditional medicinal plant from India (126.8 mg/mL) (Sen et al, 2013). In general, the IC 50 values to scavenge H 2 O 2 are higher in comparison with other ROS and RNS and sometimes the IC 50 could be not achieved in the maximum concentration tested Sen et al, 2013).…”

Section: Scavenging Of Ros and Rns By Vismia Cauliflora Extractsmentioning

confidence: 97%

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Bioactive compounds and scavenging capacity of extracts from different parts ofVismia caulifloraagainst reactive oxygen and nitrogen species

Ribeiro¹,

Berto

Chisté

et al. 2015

Pharmaceutical Biology

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Context: Vismia cauliflora A.C.Sm. [Hypericaceae (Clusiaceae)] is a plant from Amazonian forest. It is used by Amerindians to treat dermatosis and inflammatory processes in the skin and has been considered an interesting source of bioactive compounds. Objective: We evaluated the scavenging capacity of extracts from V. cauliflora (leaf, branch, stem bark, flower, and whole fruit) against reactive oxygen (ROS) and nitrogen species (RNS), namely, superoxide radical (O . The identification and the quantification of phenolic compounds and carotenoids were carried out by HPLC-DAD-ESI-MS/MS and HPLC-DAD, respectively. Results: (À)-Epicatechin and proanthocyanidin dimers and trimer were the major phenolic compounds tentatively identified in leaf, branch, stem bark, and flower extracts, while dihydroxybenzoic acids were the major compounds in whole fruit extracts. All-trans-zeinoxanthin and all-trans-b-carotene were the major carotenoids tentatively identified in leaf extracts. All extracts of V. cauliflora showed high efficiency against all tested ROS and RNS, although flower and stem bark extracts exhibited the most remarkable scavenging capacity, especially for NO and ONOO À . Discussion and conclusion: Vismia cauliflora has great potential to be used in the development of phytopharmaceutical products due to its characteristic of being a promising source of bioactive compounds with high antioxidant properties.

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Section: Scavenging Of Ros and Rns By Vismia Cauliflora Extractsmentioning

confidence: 96%

Section: Scavenging Of Ros and Rns By Vismia Cauliflora Extractsmentioning

confidence: 97%

Bioactive compounds and scavenging capacity of extracts from different parts ofVismia caulifloraagainst reactive oxygen and nitrogen species

Ribeiro¹,

Berto

Chisté

et al. 2015

Pharmaceutical Biology

Self Cite

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“…This ONOO À scavenging capacity is equivalent to that of other strong natural scavengers like nordihydroguaiaretic acid 18) and a Juglans regia leaf extract. 19) These four effective extracts were then selected for a further investigation of the inhibition effects on DNA single breakage, tyrosine nitration and LDL oxidation.…”

Section: Inhibition Effects Of the Herb Extracts On Onoo à -Induced Fmentioning

confidence: 99%

Evaluation of the Protective Effects of Chinese Herbs against Biomolecule Damage Induced by Peroxynitrite

Luo

Pan

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…Walnut leaves have been widely used in folk medicine for the treatment of skin inflammations, venous insufficiency, haemorrhoidal symptomatology, hyperhidrosis and ulcers and for its antidiarrheic, antihelmintic, antiseptic, depurative and astringent properties (Almeida et al 2008;Eidi et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Based on these traditional uses and from the wide availability of walnut leaves in abundant amounts, numerous studies have been conducted in recent years related to the content of the leaves in bioactive compounds, their antioxidant and antiseptic properties, in order to justify, at least partially, their therapeutic uses (Pereira et al 2007;Almeida et al 2008;Amaral et al 2008;Carvalho et al 2010;Cosmulescu et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Optimization of ultrasound-assisted hydroalcoholic extraction of phenolic compounds from walnut leaves using response surface methodology

Nour

Trandafir

Cosmulescu

2016

Pharmaceutical Biology

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Context Walnut leaves are highly appreciated for their pharmacological effects and therapeutic properties which are mainly attributed to their high content of phenolic compounds. Objective This study optimizes ultrasound assisted hydroalcoholic extraction (UAE) of phenolic compounds from dried walnut leaves by the maximization of total phenolics content (TPC) and total flavanoids content (TFC) of the extracts. Materials and methods Optimal conditions with regard to ethanol concentration (X 1 : 12.17-95.83% v/v), extraction time (X 2 : 8.17-91.83 min) and liquid-to-solid ratio (X 3 : 4.96-25.04 v/w) were identified using central composite design combined with response surface methodology. A high-performance liquid chromatography method with diode-array detection was used to quantify phenolic acids (gallic, vanillic, chlorogenic, caffeic, syringic, p-coumaric, ferulic, sinapic, salicylic, ellagic and trans-cinnamic), flavonoids (catechin, epicatechin, rutin, myricetin and quercetin) and juglone in the extracts. Results Liquid-to-solid ratio and ethanol concentration proved to be the primary factors affecting the extraction efficiency. The maximum predicted TPC, under the optimized conditions (61% ethanol concentration, 51.28 min extraction time and 4.96 v/w liquid-to-solid ratio) was 10125.4 mg gallic acid equivalents per liter while maximum TFC (2925 mg quercetin equivalents per liter) occurred at 67.83% ethanol concentration, 4.96 v/w liquid-to-solid ratio and 49.37 min extraction time. High significant correlations were found between antioxidant activity and both TPC (R 2 ¼ 0.81) and TFC (R 2 ¼ 0.78). Discussion and conclusion Extracts very rich in polyphenols could be obtained from walnut leaves by using UAE, aimed at preparing dietary supplements, nutraceuticals or functional food ingredients. ARTICLE HISTORY

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Walnut (Juglans regia) leaf extracts are strong scavengers of pro-oxidant reactive species

Cited by 103 publications

References 37 publications

Bioactive compounds and scavenging capacity of extracts from different parts ofVismia caulifloraagainst reactive oxygen and nitrogen species

Bioactive compounds and scavenging capacity of extracts from different parts ofVismia caulifloraagainst reactive oxygen and nitrogen species

Evaluation of the Protective Effects of Chinese Herbs against Biomolecule Damage Induced by Peroxynitrite

Optimization of ultrasound-assisted hydroalcoholic extraction of phenolic compounds from walnut leaves using response surface methodology

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