Lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia (LPL/WM) is a distinct clinicopathologic entity consisting of bone marrow infiltration by small lymphocytes, lymphoplasmacytoid lymphocytes and plasma cells with a corresponding IgM paraprotein. The most common presenting symptoms include fatigue, shortness of breath, various symptoms associated with anemia, and an increased bleeding tendency. Small subsets of patients have symptoms of a true hyperviscosity syndrome including mucosal bleeding, retinal hemorrhage and neurologic symptoms. LPL/WM typically occurs in an older population and has an indolent course with a median survival of 5 -10 years [1,2].We report a case of a 57-year-old woman who presented 7 years after orthotopic liver transplant for primary biliary cirrhosis (PBC) with new onset fatigue and massive ascites. Laboratory evaluation revealed aspartate aminotransferase (AST) and alanine aminotransferase (ALT) to be in the normal range (30 IU/L and 19 IU/L, respectively), total bilirubin in the normal range at 0.8 mg/dl, and alkaline phosphatase elevated at 234 IU/L. Serology showed negative hepatitis C virus antibody and positive hepatitis B surface antigen. Her immunosuppression was tacrolimus 3 mg twice a day. Serum protein electrophoresis (SPEP) revealed a monoclonal IgM kappa protein at a level of 2.72 g/dl. The IgM kappa was also present in the ascitic fluid at a level of 1.3 g/dl. The presence of a monoclonal IgM protein was clinically suspicious for a post-transplant lymphoproliferative disorder (PTLD), specifically LPL/WM. Initial ascitic fluid cytology, flow cytometry, and bone marrow biopsy were nondiagnostic for lymphoma.Over the next several months, the patient's ascites did not improve and paraprotein levels remained stable. Repeated ascitic fluid cytology and flow cytometry studies were negative. Serum viscosity was in the normal range at 1.5 cp. Epstein-Barr virus (EBV) DNA quantitation was 3036 copies/ml which was considered elevated but not remarkably so. Tacrolimus was decreased to 1 mg twice a day with the suspicion of PTLD. A liver biopsy showed recurrent PBC with bridging fibrosis, no evidence of lymphoma, and EBV immunohistochemistry was negative.Five months after initial presentation, the patient's serum monoclonal IgM level increased to 3.61 gm/ dl. Repeated EBV titers showed a decrease in copy number to 1412 copies/ml despite an increased paraprotein. Ascitic fluid cytology now showed atypical cells, but remained nondiagnostic ( Figure 1A). Ascitic fluid flow cytometry identified a population of large B cells positive for CD45, CD19, dim CD20, and dim CD38 with kappa light chain restriction. The cells were negative for CD10, CD5, CD23, CD7, CD2, and CD1. Plasma cells with kappa light chain restriction were also present. Repeat bone marrow biopsy now displayed paratrabecular and intertrabecular aggregates of lymphocytes and plasma cells which comprised approximately 50% of the specimen ( Figure 1B, 1C). Immunohistochemical stains on the bone marrow included a CD138 whi...