Waitlist Mortality Decreases with Increased Use of Extended Criteria Donor Liver Grafts at Adult Liver Transplant Centers

Barshes, Neal R.; Horwitz, Irwin B.; Franzini, Luisa; Vierling, John M.; Goss, John A.

doi:10.1111/j.1600-6143.2007.01758.x

Cited by 113 publications

(76 citation statements)

References 17 publications

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“…Despite rising numbers of organ donors in many countries, the gap between demand and availability of donor livers is increasing, with waiting lists and pretransplant mortality growing in many countries (1,2). On April 1, 2014, 552 patients were on the UK liver transplant waiting list.…”

Section: Introductionmentioning

confidence: 99%

Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial

Ravikumar

Jassem

Mergental

et al. 2016

American Journal of Transplantation

410

412

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Joint first authors. ISRCTN 14355416.The number of donor organs suitable for liver transplantation is restricted by cold preservation and ischemia-reperfusion injury. We present the first patients transplanted using a normothermic machine perfusion (NMP) device that transports and stores an organ in a fully functioning state at 37°C. In this Phase 1 trial, organs were retrieved using standard techniques, attached to the perfusion device at the donor hospital, and transported to the implanting center in a functioning state. NMP livers were matched 1:2 to cold-stored livers. Twenty patients underwent liver transplantation after NMP. Median NMP time was 9.3 (3.5-18.5) h versus median cold ischaemia time of 8.9 (4.2-11.4) h. Thirty-day graft survival was similar (100% NMP vs. 97.5% control, p = 1.00). Median peak aspartate aminotransferase in the first 7 days was significantly lower in the NMP group ) versus , p = 0.03). This first report of liver transplantation using NMP-preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation. NMP may be valuable in increasing the number of donor livers and improving the function of transplantable organs.Abbreviations: AST, aspartate transaminase; DBD, donation after brain death; DCD, donation after circulatory death; IRI, ischemia-reperfusion injury; IVC, inferior vena cava; MELD, model for end-stage liver disease; NHSBT, National Health Service Blood and Transplant; NMP, normothermic machine perfusion

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Section: Introductionmentioning

confidence: 99%

Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial

Ravikumar

Jassem

Mergental

et al. 2016

American Journal of Transplantation

410

412

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“…The 5-years graft survival was 83% in the low risk (ECD 0-1) group vs 62% in the intermediate (ECD [2][3][4], and 0% high risk (ECD >4) group [18]. A recent large study by European Liver Intestine Transplant Association (ELITA) and Eurotransplant Liver Intestine Advisory Committee (ELIAC) reports more than 50% incidence of ECDs in ET in 2012 [19].…”

mentioning

confidence: 99%

Extended criteria donors in liver transplantation Part I: reviewing the impact of determining factors

Nemes

Gámán

Polak

et al. 2016

Expert Review of Gastroenterology & Hepatology

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“…An extended criteria donor score ≤ 2 is associated with acceptable outcomes. [1][2][3][4][5] Donation after cardiac death: These donors have been known previously as non-heart-beating donors. Care in the operating room is withdrawn after adequate consent is obtained from the family.…”

Section: Introductionmentioning

confidence: 99%

Expanding the Donor Pool for Liver Transplants: A 2014 Summary

Gürakar¹,

Dagher²

2014

Exp Clin Transplant

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Waitlist Mortality Decreases with Increased Use of Extended Criteria Donor Liver Grafts at Adult Liver Transplant Centers

Cited by 113 publications

References 17 publications

Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial

Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial

Extended criteria donors in liver transplantation Part I: reviewing the impact of determining factors

Expanding the Donor Pool for Liver Transplants: A 2014 Summary

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