Waist circumference is a major determinant of oxidative stress in subjects with and without metabolic syndrome

Awadallah, Samir; Hasan, Hayder; Attlee, Amita; Raigangar, Veena; Unnikannan, Hema; Madkour, Mohamed; Abraham, Mini Sara; Rashid, L.

doi:10.1016/j.dsx.2019.07.010

Cited by 14 publications

(14 citation statements)

References 38 publications

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“…Other studies on normal obese subjects by giving 4 g of cinnamon capsules for 56 days showed a decrease in BMI, but not significantly different [18]. Waist circumference can be the best predictor of oxidative stress, shown in a study of Awadallah et al in subjects with large waist circumference showed significantly lower levels of antioxidant enzymes and GSH, thus higher levels of MDA and carbonyl protein [19].…”

Section: Discussionmentioning

confidence: 82%

The Effects of Herbs-Infused Water on Body Weight and Waist Circumference in Patients With Metabolic Syndrome

Purwanti¹,

Sugiarto²,

Indarto³

2021

Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020)

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Adults with metabolic syndrome have higher risks to suffer non communicable diseases like diabetes mellitus and cardiovascular diseases. In daily life, some Indonesian communities have routinely drunk spices and herbs-infused water instead of drinking pure water. However, the efficacy of this mixed water for patients with metabolic syndrome has not been established. The aim of this study was therefore to evaluate the effects of herbs-infused water (HIW) on body weight and waist circumference in patients with metabolic syndrome. This study used a quasi-experiment with pre-posttests control group design. A number of 24 patients who had metabolic syndrome and visited to Cakranegara Health Centre was participated in this study. They were randomly divided into two groups: control group drank water as usual whilst treatment group drank water as usual + 250 ml herbs-infused water for 14 days. Their body weight and waist circumference were measured before and after intervention. There were only 23 research participants who completed this study. Herbs-infused water contained 12,769 ppm of total antioxidant activity. After 14 days treatment, the body weight mean (56.7±9.3 kg) in the treatment group reduced significantly, compared with body weight mean (59.8±10.2 kg) before treatment and (68.1±18 kg) in the control group. In addition, a slightly reduction of waist circumference occurred in the treatment group but not in the control group. In conclusion, regular drinking of 250 ml herbs-infused water for 14 days is able to reduce by 3 kg body weight in patients with metabolic syndrome. This finding may provide an alternative nutrition therapy for metabolic syndrome in future.

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Section: Discussionmentioning

confidence: 82%

The Effects of Herbs-Infused Water on Body Weight and Waist Circumference in Patients With Metabolic Syndrome

Purwanti¹,

Sugiarto²,

Indarto³

2021

Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020)

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“…Other studies reported increased MDA levels in adolescents with obesity as compared with adolescents without obesity [32]. Several other studies found strong associations of MDA or TBARS with overweight/obesity or waist circumference (WC) [5,33,34]. In obese and overweight men and women, lipid peroxidation increases significantly with increasing BMI, while elevated MDA also occurs in obese adolescents and children between 8 and 18 years old [35].…”

Section: Discussionmentioning

confidence: 99%

“…MetS is accompanied by increased reactive oxygen (ROS) and nitrogen (RNS) species and decreases in antioxidant defenses creating an environment that promotes oxidative and nitrosative stress (O&NS) [3,4]. Decreased levels of antioxidant enzymes including catalase, superoxide dismutase and glutathione peroxidase, and increased levels of malondialdehyde (MDA, indicating lipid peroxidation) and protein carbonyls (indicating protein oxidation) were observed in MetS [5]. Furthermore, concentrations of nitric oxide metabolites (NOx) are associated with MetS [6], while other studies reported lower concentrations of nitric oxide (NO) formation biomarkers in adult MetS [7,8].…”

Section: Introductionmentioning

confidence: 99%

Increased Aldehyde Formation as a Key Component of the Metabolic Syndrome in Adolescents: A Machine Learning Study

Bonifácio¹,

Maes²,

Farias³

et al. 2020

Preprint

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Purpose: To investigate the alterations in nitro-oxidative stress (OS) and antioxidant status in adolescents with metabolic syndrome (MetS) and whether these alterations occur independently from effects of overweight or obesity.Methods: Blood was collected in 47 adolescents with MetS and 94 adolescents without MetS as assessed with the International Diabetes Federation criteria. The International Obesity Task Force (IOTF) criteria were used to classify the subjects into those with overweight or obesity. We measured nitro-oxidative biomarkers including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), and malondialdehyde (MDA), and antioxidant biomarkers, i.e. total radical-trapping antioxidant parameter (TRAP), paraoxonase (PON)-1 activity, thiol (SH-) groups, as well as tumor necrosis factor-α, glucose, insulin, triglycerides, uric acid and high-density lipoprotein cholesterol (HDL-C).Results: Logistic regression analysis showed that increased MDA and NOx and a lowered TRAP/uric acid ratio were associated with MetS. Machine learning including soft independent modeling of class analogy (SIMCA) showed that the top-3 most important features of MetS were increased glucose and MDA and lowered HDL-C. Support vector machine using MDA, glucose, insulin, HDL-C, triglycerides and body mass index as input variables yielded a 10-fold cross-validated accuracy of 89.8% when discriminating MetS from controls. The association between MetS and increased MDA was independent from the effects of overweight-obesity. glucose, insulin, triglycerides and HDL-C.Conclusion: In adolescents, increased MDA formation is a key component of MetS, indicating that increased production of reactive oxygen species with consequent lipid peroxidation and aldehyde formation participate in the development of MetS.

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“…The concept that RONS/NOTOX are associated with MetS and its outcomes, such as coronary artery disease and type 2 diabetes, was previously described (Roberts and Sindhu, 2009). Recently, lower levels of antioxidant defenses and increased levels of MDA and protein carbonyl, another biomarker for protein damage, were found in subjects with MetS in comparison to subjects without MetS (Awadallah et al, 2019). We found that MetS was associated with increased levels of MDA and AOPP, but not with changes in SOD1, LOOH and NOx.…”

Section: Increased Rons/nostox In Metsmentioning

confidence: 96%

Increased Nitro-Oxidative Toxicity in Association With Metabolic Syndrome, Atherogenicity and Insulin Resistance in Patients With Affective Disorders

Morelli¹,

Maes²,

Bonifácio³

et al. 2021

Preprint

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Background: There is a strong comorbidity between mood disorders and metabolic syndrome (MetS). Increased levels of reactive oxygen and nitrogen species (RONS) and nitro-oxidative stress toxicity (NOSTOX) partially underpin this comorbidity.Aims: To examine the associations of RONS/NOSTOX biomarkers with MetS after adjusting for the significant effects of mood disorders (major depression, and bipolar type 1 and 2), generalized anxiety disorder (GAD), tobacco use disorder (TUD), and male sex.Methods: The study included subjects with (n=65) and without (n=107) MetS and measured levels of superoxide dismutase 1 (SOD1), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) and computed z unit-weighted composite scores which reflect RONS/NOSTOX. The study included 105 patients with mood disorders, 46 with GAD, and 95 with TUD.Results: MetS was associated with increased levels of MDA and AOPP, independently from mood disorders, TUD, sex and GAD. Atherogenicity and insulin resistance (IR) were significantly associated with a NOSTOX composite score. Mood disorders, TUD, GAD, male sex and MetS independently contribute to increased RONS/NOSTOX. The RONS/NOSTOX profile of MetS was different from that of GAD, which showed increased SOD1 and NOx levels. TUD was accompanied by increased SOD1, LOOH and MDA, and male sex by increased LOOH and AOPP.Conclusions: MetS is characterized by increased lipid peroxidation with aldehyde formation and chlorinative stress, and atherogenicity and IR are strongly mediated by RONS/NOSTOX. Partially shared RONS/NOSTOX pathways underpin the comorbidity of MetS with mood disorders, GAD, and TUD.

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Waist circumference is a major determinant of oxidative stress in subjects with and without metabolic syndrome

Cited by 14 publications

References 38 publications

The Effects of Herbs-Infused Water on Body Weight and Waist Circumference in Patients With Metabolic Syndrome

The Effects of Herbs-Infused Water on Body Weight and Waist Circumference in Patients With Metabolic Syndrome

Increased Aldehyde Formation as a Key Component of the Metabolic Syndrome in Adolescents: A Machine Learning Study

Increased Nitro-Oxidative Toxicity in Association With Metabolic Syndrome, Atherogenicity and Insulin Resistance in Patients With Affective Disorders

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