Wachstumshemmung intraokularer proliferativer Explantate unter in-vitro-Bedingungen durch Verapamil

Abstract

A larger number of cases would have to be studied to permit more comprehensive conclusions.

Verapamil Inhibits Proliferation, Migration and Protein Kinase C Activity in Human Retinal Pigment Epithelial Cells

“…Verapamil inhibits calcium channels in a nanomolar range (Catterall, Seagar and Takahashi, 1988 ;Richter et al, 1993). Because we did not demonstrate any effects on RPE proliferation and migration at these low concentrations, we focused on the possibility that verapamil may be acting through its known effects on PKC (Mori et al, 1980).…”

“…Verapamil has been shown to inhibit the formation of postsurgical peritoneal adhesions in rabbits (Steinleitner et al, 1990), while in vitro studies have shown that calcium channel blockers inhibit the proliferation of epi-, suband preretinal membranes (Richter, Hatvani and To! th, 1993), as well as the proliferation of tumor cells (Batra et al, 1991 ;Bertrand et al, 1994 ; 0014-4835\98\070045j08 $30.00\0…”