2001
DOI: 10.1023/a:1014511415473
|View full text |Cite
|
Sign up to set email alerts
|

Untitled

Abstract: Effect of one-day and chronic (3 week) drinking of 0.1% caffeine as a single source of fluid on anxiety in rats with different anxiety level (either genetically determined or individually acquired) was studied. When housed in groups, Fisher-344 rats had a significantly higher anxiety level than WAG/G rats. When the rats were housed individually, their anxiety gradually increased. The effect of short-term and chronic intake of caffeine in high doses depended on both genetically determined sensitivity to this ag… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
1
0

Year Published

2005
2005
2024
2024

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 7 publications
(2 citation statements)
references
References 5 publications
0
1
0
Order By: Relevance
“…We previously showed that Fischer-344 rats were highly sensitive to the analgesic and positive reinforcing effects of morphine. The density of cerebral opioid receptors was decreased in these animals [1,2,7]. Presumably, the presence of antiidiotypic antibodies in the blood through its direct agonistic effect on the peripheral opioid receptors leads to "reflected" effects in the CNS, which can result in increased sensitivity to the analgesic and positive reinforcing effects of opiates.…”
Section: S K Sudakov and I V Rusakovamentioning
confidence: 99%
“…We previously showed that Fischer-344 rats were highly sensitive to the analgesic and positive reinforcing effects of morphine. The density of cerebral opioid receptors was decreased in these animals [1,2,7]. Presumably, the presence of antiidiotypic antibodies in the blood through its direct agonistic effect on the peripheral opioid receptors leads to "reflected" effects in the CNS, which can result in increased sensitivity to the analgesic and positive reinforcing effects of opiates.…”
Section: S K Sudakov and I V Rusakovamentioning
confidence: 99%
“…According to Sudakov et al [71], the impact of caffeine use depends on the genetic susceptibility to the drug as well as environmental elements, such as social isolation. Anxiety only rose in low-anxious rats kept in comfortable environments following chronic caffeine use, while short-term caffeine consumption had a more noticeable effect on highanxious rats, especially those placed individually [71].…”
Section: Short-term Studies On Animalsmentioning
confidence: 99%