Influence of Caffeine Consumption by Pregnant Rats on Behavior and Learning in Their Offspring

Bashkatova, Valentina; Alekseeva, E. I.; Bogdanova, N. G.; Назарова, Г. А.; Sudakov, S. K.

doi:10.1007/s10517-018-4154-2

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Learning and behavioral effects of long-term prenatal caffeine administration were investigated. As a result, long-term caffeine intake of pregnant rats during pregnancy has been found to change the locomotor activity of the offspring (36). For therapeutic purposes, the protective effects of melatonin and nicotine on the bones were investigated and compared to the control group (43.71 ± 2.33), 6 mg/kg nicotine group (31.42 ± 10.33)…”

Section: Discussionmentioning

confidence: 99%

The protective role of melatonin against the effects of different doses of caffeine on the fetus

Yılmaz

Göçmen

Arikan

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Skeletal system and some organs development changes in rat fetuses with 30 and 60 mg/kg caffeine and melatonin's (10 mg/kg) protective role against rat fetuses were investigated. Groups (n = 4) were formed as Control, LDC, HDC, LDC+melatonin, HDC+melatonin and melatonin. Fetuses were taken by cesarean section and stained using dual skeletal staining method and FESEM. TRAP and AP immune-reactivity concentrations were calculated. Oxidative stress and inflammatory markers were also measured by liver, bone and placenta samples. TNF-α, IL-1ß, IL-6, VEGF-A, SOST and Fetuin-A levels were measured in tissue by using ELISA. TBARS, SOD, GSH, GSSG, TOS, TAS, measured by spectrophotometric assay method. The mRNA levels of Agtr2 gene expressed in placental tissues of control rats and in placental tissues of rats exposed to HDC, LDC, MEL, HDC+MEL, LDC+MEL were analyzed by Real-time PCR. The gene expressions of Agtr2 were significantly upregulated in the placentas exposed to HDC, MEL, HDC+MEL and LDC+MEL (P<0,001). No significant difference in samples of the LDC group (P>0,05). According to these data, caffeine used during pregnancy delayed ossification; melatonin, a powerful antioxidant, was found to eliminate this effect. Besides, changes in angiotensin receptor expression observed in response to a caffeine and melatonin exposure result from high dose and join effect.

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Section: Discussionmentioning

confidence: 99%

The protective role of melatonin against the effects of different doses of caffeine on the fetus

Yılmaz

Göçmen

Arikan

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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“…Recently, in vivo experimental studies on the skeleton have indicated the detrimental effects of caffeine. However, the mechanisms underlying the effect of caffeine on the developing fetal brain have not been sufficiently studied [18,19]. Antiapoptotic and anti-inflammatory effects of caffeine have been reported in recent studies [19][20][21].…”

Section: Discussıonmentioning

confidence: 99%

Biochemical Effects of Caffeine and Melatonin on RAT Embryo Brain

Nisari¹,

Yılmaz²,

Göçmen³

et al. 2020

UCMS

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Background:Oxidative stress plays an important role in fetus brain development. The aim of this study was to investigate the protective role of melatonin against the effect of caffeine (given 30 mg/kg and 60 mg/kg) in embryo brain.Material and Methods:For this purpose, 35 adult female Sprague-Dawley rats were used in the study. Pregnant rats were detected by vaginal smear test and were divided into seven groups with five rats per group.Thirty(30) mg/kg and 60 mg/kg caffeine were administered to the experimental groups between the 1st and 20th days of pregnancy, while melatonin (10 mg/kg) was administered to the treatment groups in addition to caffeine. On the 20th day of pregnancy, fetuses were taken by cesarean section and their weights/lengths were measured.Results:Superoxide dismutase (SOD), glutathione (GSH), glutathione disulfide (GSSG), total antioxidant status (TAS), thiobarbituric acid reactive substances (TBARS), calcium (Ca) and vitamin D (Vit D) levels were measured by spectrophotometric methods. Oxidative stress index (OSI) and total glutathione (GSH/GSSG) levels were the markers used for oxidative stress and measured by TOS/TAS and GSH/GSSG, respectively. All data were statistically evaluated.Conclusion:In this study, it was observed that high dose caffeine reduces oxidative stress in brain tissues while increasing the antioxidant level.

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Effect of Nitric Oxide Synthase Inhibitor on the Learning and Spatial Memory in Rats Subjected to Long-Term Perinatal Administration of Caffeine

et al. 2022

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Influence of Caffeine Consumption by Pregnant Rats on Behavior and Learning in Their Offspring

Cited by 5 publications

References 11 publications

The protective role of melatonin against the effects of different doses of caffeine on the fetus

The protective role of melatonin against the effects of different doses of caffeine on the fetus

Biochemical Effects of Caffeine and Melatonin on RAT Embryo Brain

Effect of Nitric Oxide Synthase Inhibitor on the Learning and Spatial Memory in Rats Subjected to Long-Term Perinatal Administration of Caffeine

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