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New Pd(II) and Pt(II) complexes with N,S-chelated pyrazolonate ligands: Molecular and supramolecular structure and preliminary study of their in vitro antitumoral activity

“…Crystal data were collected at the RIAIDT services of the University of Santiago de Compostela on a Bruker SMART-CCD 1000 diffractometer (½PdL 4 2 Á DMSO and ½PtL 5 2 Á 2DMSO) and at the São Carlos Institute of Physics of the University of São Paulo on an Enraf-Nonius CAD-4 diffractometer. Data were corrected for absorption by SADABS [21] (½PdL 4 2 Á DMSO and ½PtL 5 2 Á 2DMSO) or multi-scan [22].…”

“…Data were corrected for absorption by SADABS [21] (½PdL 4 2 Á DMSO and ½PtL 5 2 Á 2DMSO) or multi-scan [22]. The structures were solved using the heavy atom method followed by normal difference Fourier techniques.…”

“…In ½PdL 3 2 the disorder affects the C(16) carbon atom occupying three different positions with occupation factors of 0.35, 0.35 and 0.3, and in this complex there are two independent molecules in the cell. The asymmetric unit of ½PdL 4 2 Á DMSO also includes two molecules of complex and two molecules of DMSO. In the latter the S atoms are disordered in two positions with occupation factors of 0.5 in one case and 0.7 and 0.3 in the other.…”

“…Surprisingly, structural information concerning the 5-pyrazolone complexes with Pd(II) and Pt(II) is rather scarce, although their interaction with palladium has been used in the analysis of the metal [2], in its extraction chemistry [3] and in the preparation of a selective hydrogenation catalyst [4]. According to a structural search of the Cambridge Structural Database (CSD) [5] and a survey of recent literature in SciFinder Ò Scholar, only the Pd(II) derivatives of a phosphoranylidene-substituted pyrazolone [6] and a phosphinopyrazolonate [7] have been prepared and structurally identified by X-ray diffraction.…”

Nitro and related compounds

“…58 A mild hydrogenation of nitro aromatics, in the presence of γ-Al 2 O 3 supported palladium()-pyrazol-5-one complexes, has been reported to give anilines in 95-98% yield. 59 Nitrobenzenes have also been chemoselectively reduced to anilines using decaborane in the presence of palladium on carbon and a trace amount of acetic acid and methanol at reflux in 81-97% yield. 60…”