New Pd(II) and Pt(II) complexes with N,S-chelated pyrazolonate ligands: Molecular and supramolecular structure and preliminary study of their in vitro antitumoral activity

Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity

“…The cytotoxicity of these ligands is enhanced by coordination to metal ions such as copper, zinc, platinum and palladium. This activity is explained not only by the metals' ability to influence lipophilicity but also the mechanism of action within the cell [18][19][20][21][22][23][24][25][26]. Substitution on the C 2 position can also affect the coordination and biological properties.…”

Palladium(II) and platinum(II) bis(thiosemicarbazone) complexes of the 2,6-diacetylpyridine series with high cytotoxic activity in cisplatin resistant A2780cisR tumor cells and reduced toxicity

“…In this regard and taking into account that one of the mechanisms 54 inducing the nephrotoxicity is due to the inactivation of some enzymes 55 because of the reaction between platinum ions and sulfur containing 56 proteins, an active area of research focuses on the synthesis of chelate 57 platinum(II) complexes bearing nitrogen and sulfur mixed donor 58 atoms, which should prevent the adverse reaction described [11,12]. non-covalent DNA binding [13][14][15][16][17][18][19].…”

Novel palladium complexes for catalysis and biomedical applications

“…complexes are intriguing alternative candidates for metallo-antitumor drugs due to their structural and thermodynamic similarities to platinum(II) complexes [1,2]. Several studies demonstrate that palladium derivates exhibit a noticeable cytotoxic activity, similarly to standard platinum-based drugs used as reference, and show fewer side effects relative to other heavy metal anticancer compounds [3].…”