Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity

Abstract

New Cu(II), Pd(II) and Pt(II) complexes, (Cu(L)(H 2 O) 2 (OAc)) ( 1 ), (Cu(HL)(H 2 O) 2 (SO 4 )) ( 2 ), (Cu(L)(H 2 O) 2 (NO 3 )) ( 3 ), (Cu(L)(H 2 O) 2 (ClO 4 )) ( 4 ), (Cu(L) 2 (H 2 O) 2 ) ( 5 ), (Pd(L)(OAc))H 2 O ( 6 ), and (Pt(L) 2 ) ( 7 ) were synthesized from 8-ethyl-2-hydroxytricyclo(7.3.1.0 2,7 )tridecan-13-one thiosemicarbazone ( HL ). The ligand and its metal complexes were characterized by IR, 1 H-NMR, 13 C-NMR, UV-Vis, FAB, EPR, mass spectroscopy, elemental and thermal analysis, magnetic susceptibility measurements and molar electric conductivity. The free ligand and the metal complexes have been tested for their antimicrobial activity against E. coli , S. enteritidis , S. aureus , E. faecalis, C. albicans and cytotoxicity against the NCI-H1573 lung adenocarcinoma, SKBR-3 human breast, MCF-7 human breast, A375 human melanoma and HL-60 human promyelocytic leukemia cell lines. Copper complex 2 exhibited the best antiproliferative activities against MCF-7 human breast cancer cells. A significant inhibition of malignant HL-60 cell growth was observed for copper complex 2 , palladium complex 6 and platinum complex 7 , with IC 50 values of 1.6 µM, 6.5 µM and 6.4 µM, respectively.

Novel azomethine Pd (II)‐ and VO (II)‐based metallo‐pharmaceuticals as anticancer, antimicrobial, and antioxidant agents: Design, structural inspection, DFT investigation, and DNA interaction

“…These results displayed that the metal ions play a significant part in the interaction with separated DNA, so we could conclude that the compound minimizes the growth of the pathogenic organism through interaction with genome. Our results revealed that partial binding to DNA was observed by VO (II) and Pd (II) imine metal chelates …”

“…The viscosity measurements show that all the as‐prepared metal complexes intercalate between adjacent CT‐DNA base pairs, giving rise to lengthening of the DNA double helix and an increase in viscosity, as shown in Figure . The results suggest that all the metal‐imine complexes intercalate with the adjacent base pairs, thereby causing lengthening of the DNA helix, which facilitates the intercalation mode of CT‐DNA with the as‐prepared metal‐imine complexes …”

Synthesis, characterization, crystal structure of novel Cu (II), Co (III), Fe (III) and Cr (III) complexes with 2‐hydroxybenzaldehyde‐4‐allyl‐S‐methylisothiosemicarbazone: Antimicrobial, antioxidant and in vitro antiproliferative activity

“…calcd for C 12 2.3 | General procedure for the preparation of the metal complexes (1)(2)(3)(4)(5)(6)(7)(8)(9) All the new metal complexes 1-9 were prepared by the direct reaction between the ligand and the corresponding metal salts. : 142-144°C; yield (83%); FW: 249.332 g mol −1 .…”

“…Abs control -Abs sample À Á =Abs control À Á ·100: (9) were synthesized in ethanol in good yield. Single crystals were obtained for six coordination compounds (3), (5-9) and ligand HL·HI·C 2 H 5 OH with recrystallization from various solvents, such as DMSO, DMF, methanol, ethanol, chloroform, and their structures found using X-ray analysis.…”

“…The electronic spectra of complexes 4-6 show d-d bands in the regions 15.150-16.120, 19.230-19.607 and 23.800-25.000 cm −1 , which may be assigned to 1 A 1g → 3 T 2g , 1 A 1g → 1 T 1g , 1 A 1g → 1 T 2g transitions, respectively, due to the octahedral geometry. [59] 3.4 | Structural characterization of (HL), (7), [Fe (L) 2 ]NO 3 (8) and [Cr (L) 2 NO 3 (9) The single crystal X-ray study has revealed that the ligand and complexes 3, 5-9 have molecular structure as depicted in Figure 1. The electronic spectra exhibited three bands at 17.090-17.850, 20.830-21.500 and 25.970-25.260 cm −1 due to the 6 A 1g → 4 T 1g , 6 A 1g → 4 A 1g and 6 A 1g → 4 T 2g (D) transitions, respectively, in an octahedral geometry.…”