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Yamazaki, Toshimasa; Kamijo, Keita; Kenmochi, Akihisa; Fukuzumi, Shunichi; Kiyuna, Tomoharu; Takaki, Yoko; Kuroiwa, Yoshihiro

doi:10.1023/a:1023467806268

Cited by 67 publications

(13 citation statements)

References 82 publications

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“…In addition to sources in PFC (e.g., ACC), these studies have also identified sources of the reward-modulated P300 in the posterior cingulate cortex (Kamarajan et al, 2010; Zhou, Yu, & Zhou, 2010). In addition, the nonreward-modulated P300, elicited by a range of task demands, has been localized to PFC, including ACC, OFC, VLPFC, and the middle and inferior frontal gyri (Volpe et al, 2007; Neuhaus et al, 2006; Mulert et al, 2004; Yamazaki et al, 2000; Halgren, Marinkovic, & Chauvel, 1998), the inferior temporal gyrus (Bledowski et al, 2004), the parietal lobe (Moores et al, 2003), and the TPJ (Mulert et al, 2004). Therefore, it is likely that the structural integrity of PFC may contribute directly but also indirectly, via PFC interactions with more posterior brain regions, to adaptive modulation of the P300 response to both reward and nonreward contingencies.…”

Section: Discussionmentioning

confidence: 99%

Structural Integrity of the Prefrontal Cortex Modulates Electrocortical Sensitivity to Reward

Parvaz

Konova

Tomasi

et al. 2012

Journal of Cognitive Neuroscience

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The P300 is a known ERP component assessing stimulus value, including the value of a monetary reward. In parallel, the incentive value of reinforcers relies on the PFC, a major cortical projection region of the mesocortical reward pathway. Here we show a significant positive correlation between P300 response to money (vs. no money) with PFC gray matter volume in the OFC, ACC, and dorsolateral and ventrolateral PFC in healthy control participants. In contrast, individuals with cocaine use disorders showed compromises in both P300 sensitivity to money and PFC gray matter volume in the ventrolateral PFC and OFC and their interdependence. These results document for the first time the importance of gray matter structural integrity of subregions of PFC to the reward-modulated P300 response.

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Section: Discussionmentioning

confidence: 99%

Structural Integrity of the Prefrontal Cortex Modulates Electrocortical Sensitivity to Reward

Parvaz

Konova

Tomasi

et al. 2012

Journal of Cognitive Neuroscience

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“…P100 is closely related to selective attention and the consumption of attention resources [16] while N100 is said to reflect attention orientation and/or early engagement [17]; people with ASD may require more attention resources in processing novelty and can display low selectivity for distinct stimulus categories [18]. More specifically, lesions to the lateral extra-striate cortex within this group are associated with abnormal early ERPs vis a vis occipital-parietal areas [19,20]. Such deficits may illustrate comparatively lower consumption of attention resources, low selectivity between stimulus classes, and impairments in early orienting of attention to newly appearing visual stimuli.…”

Section: Introductionmentioning

confidence: 99%

“…Given that groups with ASD and TD groups do not generally show significant differences in the P3b component [29,30], impairments within the former group may not reflect sustained attention. Instead, group differences in P100 and N100 [18–20] suggest that problems related to ASD are more prominent in relation to initial orienting of attention that may be compensated for later stages involving sustained attention, at least when attention performance is comparable between children with ASD and TD children.…”

Section: Introductionmentioning

confidence: 99%

Early and late stage processing abnormalities in autism spectrum disorders: An ERP study

et al. 2017

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This research assessed event-related potentials (ERPs) elicited during the processing of different kinds of visual stimuli among children with Autism Spectrum Disorder (ASD) (n = 15) and typically developing (TD) children (n = 19). Within a simple visual oddball paradigm, participating children passively viewed fruit and vegetable images that were used as standard stimuli in addition to images of these foods with their usual colors modified to create novel stimuli and cartoon depictions of these images (i.e., “deviant” stimuli). Analyses revealed significant main effect differences between the groups for P100, N100 and P300 components; ASD group children showing longer P100 latencies, weaker N100 amplitudes and larger P300 amplitudes than did the TD group. A Group x Hemisphere interaction also emerged for N400 amplitudes but differences were not significant in simple-effects analyses. Together these results suggested children with ASD may be characterized by lower attention resource allocation and engagement during early stages of processing visual stimuli. However, ERPs in later processing stages suggested children with ASD and TD children have similar neural responses in attending to visual images as stimulus presentations continue.

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“…As it was mentioned above, the exogenous ERPs reflect early-stage, modality-specific, while endogenous ones reflect modality non-specific associative higher order processing of stimuli within the context of the task (Näätänen et al, 1978; Luck et al, 1990; Coles and Rugg, 1995; Hillyard and Annlo-Vento, 1998). Posterior visual P100 are generated within the fusiform gyrus with contribution from parieto-occipital and occipital cortices (Yamazaki et al, 2000). Frontal N100 ERP wave occurs within a similar time window and probably originates from more anterior frontal dipole generators (Clark et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism

Sokhadze

El-Baz

Sears

et al. 2014

Front. Syst. Neurosci.

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Objectives: Reports in autism spectrum disorders (ASD) of a minicolumnopathy with consequent deficits of lateral inhibition help explain observed behavioral and executive dysfunctions. We propose that neuromodulation based on low frequency repetitive Transcranial Magnetic Stimulation (rTMS) will enhance lateral inhibition through activation of inhibitory double bouquet interneurons and will be accompanied by improvements in the prefrontal executive functions. In addition we proposed that rTMS will improve cortical excitation/inhibition ratio and result in changes manifested in event-related potential (ERP) recorded during cognitive tests.Materials and Methods: Along with traditional clinical behavioral evaluations the current study used ERPs in a visual oddball task with illusory figures. We compared clinical, behavioral and electrocortical outcomes in two groups of children with autism (TMS, wait-list group). We predicted that 18 session long course in autistic patients will have better behavioral and ERP outcomes as compared to age- and IQ-matched WTL group. We used 18 sessions of 1 Hz rTMS applied over the dorso-lateral prefrontal cortex in 27 individuals with ASD diagnosis. The WTL group was comprised of 27 age-matched subjects with ASD tested twice. Both TMS and WTL groups were assessed at the baseline and after completion of 18 weekly sessions of rTMS (or wait period) using clinical behavioral questionnaires and during performance on visual oddball task with Kanizsa illusory figures.Results: Post-TMS evaluations showed decreased irritability and hyperactivity on the Aberrant Behavior Checklist (ABC), and decreased stereotypic behaviors on the Repetitive Behavior Scale (RBS-R). Following rTMS course we found decreased amplitude and prolonged latency in the frontal and fronto-central N100, N200 and P300 (P3a) ERPs to non-targets in active TMS treatment group. TMS resulted in increase of P2d (P2a to targets minus P2a to non-targets) amplitude. These ERP changes along with increased centro-parietal P100 and P300 (P3b) to targets are indicative of more efficient processing of information post-TMS treatment. Another important finding was decrease of the latency and increase of negativity of error-related negativity (ERN) during commission errors that may reflect improvement in error monitoring and correction function. Enhanced information processing was also manifested in lower error rate. In addition we calculated normative post-error treaction time (RT) slowing response in both groups and found that rTMS treatment was accompanied by post-error RT slowing and higher accuracy of responses, whereas the WTL group kept on showing typical for ASD post-error RT speeding and higher commission and omission error rates.Conclusion: Results from our study indicate that rTMS improves executive functioning in ASD as evidenced by normalization of ERP responses and behavioral reactions (RT, accuracy) during executive function test, and also by improvements in clinical evaluations.

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Cited by 67 publications

References 82 publications

Structural Integrity of the Prefrontal Cortex Modulates Electrocortical Sensitivity to Reward

Structural Integrity of the Prefrontal Cortex Modulates Electrocortical Sensitivity to Reward

Early and late stage processing abnormalities in autism spectrum disorders: An ERP study

rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism

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