Vulvar neoplasia in the young

Hilliard, George D.; Massey, Fred M.; O’Toole, Robert V.

doi:10.1016/0002-9378(79)90340-5

Cited by 42 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Developing strategies for dealing with VIN is becoming of greater importance in view of the increasing frequency with which the diagnosis is being made. As previously reported 5 , our survey shows a large increase in presentation of patients with VIN although it does not confirm reports of an increase in younger patients 6,7 . Our awareness and recognition of VIN has increased but the rise may also reflect a true increase in incidence.…”

Section: Discussioncontrasting

confidence: 81%

Vulvar intraepithelial neoplasia: long term follow up of treated and untreated women

Herod

Shafi

Rollason

et al. 1996

BJOG

106

View full text Add to dashboard Cite

Objective To investigate the long term outcome of patients with vulvar intraepithelial neoplasia. Design A retrospective study using information obtained from patient casenotes. Sample One hundred and thirty‐three women with a primary diagnosis of vulvar intraepithelial neoplasia (VIN), identified during a 15‐year period. Results The diagnosis of vulvar intraepithelial neoplasia increased throughout the study period. Human papilloma virus changes were noted in 104 patients (78%); these women were significantly younger than those without (P≤ 0.001). Nineteen (14%) were managed by observation or medical treatment and the remainder by surgical methods. Histological or symptomatic recurrence after surgical treatment occurred in 55 (48%). When disease recurred, it usually did so within four years of treatment. Recurrence was more common following laser vapourisation than after local excision (75%vs 40%; P≤ 001). Progression to invasive disease occurred in nine patients (7%), none of whom were in the group being observed. Four deaths occurred in this group, three from gynaecological malignancies of the lower genital tract. Conclusions Patients with vulvar intraepithelial neoplasia require long term follow up, and the risk of invasion may be higher than previously thought. Surgical treatment when required should be by excisional rather than ablative methods in most instances. In selected cases it is also possible to safely manage patients by more conservative methods.

show abstract

Section: Discussioncontrasting

confidence: 81%

Vulvar intraepithelial neoplasia: long term follow up of treated and untreated women

Herod

Shafi

Rollason

et al. 1996

BJOG

106

View full text Add to dashboard Cite

show abstract

“…Wide local excision with frozen section of the margins has been a common approach [55,57]. Recurrences frequently developed at the margins requiring repeat excision [55,56]. Other more extensive procedures include partial vulvectomy, simple vulvectomy, and skinning vulvectomy [58], the latter modified by Di Saia and Rich [59].…”

Section: Methods Of Treatment Of Vinmentioning

confidence: 99%

“…MANAGEMENT OF VIN The rationale for conservative management for VIN is as follows: (1) the risk of progression to vulvar invasive cancer is probably less than 5% [50,54]; (2) the transit time for in situ disease to invasive carcinoma is long, 2&30 years (except in the immune-suppressed patient) [54,55]; (3) VIN can undergo spontaneous regression [50]; (4) VIN is being diagnosed in younger women [56]; (5) recurrence develops after any treatment method; no single treatment method appears to provide any advantage over any other in terms of local control or cure [54]; (6) even vulvectomy does not remove anal canal involvement (20% of patients) [50,-5 11; (7) recurrence can involve any external site; it can be unifocal or multifocal disease and its onset is unpredictable [49]; and (8) the probability of missing an early invasive carcinoma by procedures less than vulvectomy appears insignificant in properly diagnosed patients [49].…”

Section: Rationale For Conservativementioning

confidence: 99%

Intraepithelial neoplasia of the lower female genital tract: Etiology, investigation, and management

Wright

Chapman

1992

Seminars in Surgical Oncology

View full text Add to dashboard Cite

Lower genital tract neoplasia appears associated with certain types of the human papilloma virus. Surgical approaches using lasers and electricity are available to treat the clinical diseases and in turn provide good cosmetic and functional anatomy. The surgical method employed depends upon the anatomical and histological distribution of disease regardless of its site. Of the three areas (cervix, vagina and vulva), cervical intraepithelial neoplasia is the least difficult to cure. Vulvar intraepithelial neoplasia is the most difficult since recurrences can occur at any time and in some patients for many years.

show abstract

“…whereas 13 were reported as carcinomas (4, 5,6,8,11). In comparison, intra-epithelial neoplasia and microinvasive squamous cell carcinoma of the vulva have a lower peak incidence (12)(13)(14) with a rising frequency in younger women (13). This has been doubted by others and ascribed to an improved health surveillance (14).…”

mentioning

confidence: 99%

A 16‐Year‐Old Girl With Invasive Carcinoma Of The Vulva

Nilsson

Aim

Malmström

et al. 1990

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

We present a 16-year-old girl with vulvar squamous cell carcinoma. The patient initially received a radical treatment because of lymph-node dissemination. However, recurrent disease erupted a little more than one year after the initial treatment, with metastases in the right lung and multiple osteolytic skeletal metastases. Despite aggressive treatments with chemotherapy the patient died about 2 years after the initial diagnosis. An aggressive radical treatment must be chosen for cases of invasive vulvar carcinoma, irrespective of the patient's age.

show abstract

Vulvar neoplasia in the young

Cited by 42 publications

References 6 publications

Vulvar intraepithelial neoplasia: long term follow up of treated and untreated women

Vulvar intraepithelial neoplasia: long term follow up of treated and untreated women

Intraepithelial neoplasia of the lower female genital tract: Etiology, investigation, and management

A 16‐Year‐Old Girl With Invasive Carcinoma Of The Vulva

Contact Info

Product

Resources

About