Vulvar leiomyosarcoma in Bartholin’s gland area: a case report and literature review

Bugatto, Fernando; Añón-Requena, M.J.; López-Guerrero, M. A.; Báez-Perea, José María; Bartha, José Luis; Hervías-Vivancos, B.

doi:10.1007/s00404-008-0652-1

Cited by 30 publications

(55 citation statements)

References 10 publications

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“…1,3 The tumor usually arises in the area of Bartholin's gland, at the usual place of Bartholin duct cysts, and shows clinical similarities with them, leading to difficulties in diagnosis. 4 LMS occurs more frequently in women of middle and older ages (age range, 20-68); the average age at clinical presentation is approximately 30-40 years, and the youngest patient described was aged 14 years. 5,6 The majority of these cases are from Western countries, which suggests etiopathogenic connection with lifestyle or a certain genetic predisposition.…”

Section: Leiomyosarcoma Of the Vulvamentioning

confidence: 97%

“…8 It clinically presents as a solid, infiltrating tumor mass, with diameters in the range of 1.5-16 cm (average size, 5 cm). 4 Subjectively the lesions are usually painless and asymptomatic, but in advanced stages they can be associated with voiding dysfunction or bleeding. 2 LMS shows immunoreactivity to muscle markers, which is also typical for leiomyomas; 4 namely, with desmin, smooth muscle actin, and musclespecific actin.…”

Section: Leiomyosarcoma Of the Vulvamentioning

confidence: 99%

See 1 more Smart Citation

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1

Chokoeva¹,

Tchernev

Cardoso

et al. 2015

Int J Immunopathol Pharmacol

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Malignant tumors of the female reproductive system are a serious health and social problem, as they are the second most common cause of death among women, after breast cancer. Their incidence has increased dramatically during recent years, probably due to the different sexual habits and changes in the prevalence of HIV/ AIDS and HPV virus carriers, among other factors. Vulvar tumors represent only 4% of all gynecological neoplasms, and they are fourth in frequency after tumors of the cervix, uterus, and ovary. Ninety eight percent of all vulvar tumors are benign and only 2% are malignant. The overall incidence of tumors with vulvar location is between two and seven cases per 100,000 women, and it increases with age, while the death rate is estimated at 0.7 per 100,000 women. Sarcomas of the vulva comprise approximately 1-3% of all vulvar cancers, with leiomyosarcomas, epithelioid sarcomas, and rhabdomyosarcomas being the most common among them. They are characterized by rapid growth, high metastatic potential, frequent recurrences, aggressive behavior, and high mortality rate. In this paper, we present the most common forms of sarcomas of the vulva (leiomyosarcoma, epithelioid sarcoma, malignant rhabdoid tumor, rhabdomyosarcoma) in order to emphasize the broad differential diagnosis, rare appearance, non-specific clinical picture, aggressive course, and high mortality.

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Section: Leiomyosarcoma Of the Vulvamentioning

confidence: 97%

Section: Leiomyosarcoma Of the Vulvamentioning

confidence: 99%

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1

Chokoeva¹,

Tchernev

Cardoso

et al. 2015

Int J Immunopathol Pharmacol

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“…Other symptoms include pain, itching, and redness. These tumors display rapid growth and aggressive disease course . Our patient suffered from a painless and progressively enlarging genital lump, which did not exist until six months before admission.…”

Section: Discussionmentioning

confidence: 83%

A rare case of leiomyosarcoma localized in the Bartholin's gland area and review of the literature

Korkmaz

Kurdoğlu

Karadağ

et al. 2016

J of Obstet and Gynaecol

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Sarcomas of the vulva in the Bartholin's gland area are extremely rare in adults and only a few cases have been reported in the literature. A 65-year-old female patient without any previous complaint presented to our hospital complaining of a genital lump with progressive enlargement over the last six months. Pelvic examination revealed a 6 × 5 cm solid mass lesion with irregular margins localized in the left Bartholin's gland. Preoperative pathology results indicated a benign lesion, which was subsequently totally excised. Histopathological examination of the lesion revealed leiomyosarcoma. When a lesion is localized in the Bartholin's gland area, preoperative biopsy may suggest benign cytology, which can lead to a delay in diagnosis and curative treatment. Total local excision is the first choice for vulvar-complicated masses in the Bartholin's gland area. The present case is the ninth well-documented case reported in the literature.

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“…43 The patient underwent radical hemi-vulvectomy with ipsilateral inguinal lymphadenectomy followed by chemotherapy and radiation. 43 The patient underwent radical hemi-vulvectomy with ipsilateral inguinal lymphadenectomy followed by chemotherapy and radiation.…”

Section: Leiomyoma and Leiomyosarcomamentioning

confidence: 99%

“…43 The patient underwent radical hemi-vulvectomy with ipsilateral inguinal lymphadenectomy followed by chemotherapy and radiation. 43 The authors did a literature search and reported that their patient was the seventh patient in the literature with a BG leiomyosarcoma.…”

Section: Leiomyoma and Leiomyosarcomamentioning

confidence: 99%

Lesions of the Bartholin Gland

Heller

Bean

2014

Journal of Lower Genital Tract Disease

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Most lesions of the Bartholin gland are cysts or abscesses. Clinicians are taught that lesions of the Bartholin gland occurring in older women should raise the differential diagnosis of malignancy, although these are uncommon. A variety of more unusual and rare lesions of the Bartholin gland have been reported. This review focuses on these less common entities, which must be considered as well when encountering pathology of the Bartholin gland.

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Vulvar leiomyosarcoma in Bartholin’s gland area: a case report and literature review

Abstract: Any vulvar lesion with unusual characteristics or insidious evolution in labia majora or Bartholin's glands area should be carefully and promptly studied. This is particularly important in order to perform an effective surgical treatment in cases of leiomyosarcoma.

Cited by 30 publications

References 10 publications

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1

A rare case of leiomyosarcoma localized in the Bartholin's gland area and review of the literature

Lesions of the Bartholin Gland

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