Vulvar Acantholytic Squamous Carcinoma: A Case Report With Immunohistochemical and Molecular Study

Giordano, Giovanna; D’Adda, Tiziana; Merisio, Carla; Gnetti, Letizia

doi:10.1097/01.pgp.0000157919.43978.f3

Cited by 17 publications

(17 citation statements)

References 12 publications

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“…The microscopic findings observed in the present case are compatible with those observed in other reports, where the histological characteristics observed included the formation of pseudoglandular to pseudocystic structures delimited by a layer of neoplastic cells containing individual or clustered acantholytic or dyskeratotic cells (6) or cell debris (19).…”

Section: Discussionsupporting

confidence: 81%

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Metastatic submandibular acantholytic squamous cell carcinoma in a dog

Silva¹,

Sarandy²,

Tamiasso³

et al. 2018

BJVP

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Silva, et al.; Metastatic submandibular acantholytic squamous cell carcinoma in a dog. Braz J Vet Pathol, 2018, 11(1), 19 -23 DOI: 10.24070/bjvp.1983 Abstract A seven-year-old female mixed-breed dog was diagnosed with an uncommon histological variant of squamous cell carcinoma (SCC) with lymph node metastases. Therefore, the objective of this report was to describe the gross and microscopic findings of this uncommon SCC histological variant. Fine-needle aspiration cytology of the mass revealed a squamous cell carcinoma. On necropsy, the submandibular region revealed nodular, multifocal to coalescing, ulcerated masses with firm and fluctuant areas. Furthermore, enlarged submandibular and cervical lymph nodes with loss of normal architecture suggestive of metastasis were present. A definitive diagnosis of submandibular acantholytic squamous cell carcinoma was made upon histopathological evaluation. This variant is rare in humans and animals.

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Section: Discussionsupporting

confidence: 81%

“…ASCC is a rare neoplasm in animals and humans (4,6,9,20). Therefore, the clinical and epidemiological characteristics of this tumor are not well-known.…”

Section: Discussionmentioning

confidence: 99%

Metastatic submandibular acantholytic squamous cell carcinoma in a dog

Silva¹,

Sarandy²,

Tamiasso³

et al. 2018

BJVP

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“…The pseudoangiosarcomatous carcinoma previously reported by Pitt et al 6 also had focal squamous keratinization and sarcomatoid spindle cell component. Most of the previously reported nonvesical pseudoangiosarcomatous carcinomas were squamous cell carcinoma in cutaneous and squamous mucosal sites, 2,4,5,8,11,[13][14][15][16] as well as in some visceral organs where squamous carcinoma is not typical, such as in the breast and colon. 3,7,9,10 In the current series, a relatively higher proportion of the bladder carcinomas (4/7) showed squamous differentiation, and the pseudoangiosarcomatous pattern was also exhibited by the squamous areas in 3 of the 7 tumors.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] These carcinomas were also reported under different eponyms such as acantholytic, pseudovascular, angiosarcoma-like, pseudoglandular, adenoid squamous, and pseudovascular adenoid squamous carcinomas. 1,2,5,[7][8][9][10][11][12][13][14] Most of the pseudoangiosarcomatous carcinomas previously described were squamous cell carcinomas from various organ sites such as the skin, 2-4,13 conjunctiva, 15 aerodigestive mucosa, 11,16 lungs, 3,12 breast, 3,9,10 cecum, 7 vulva, 5,6,8 uterine cervix, 14 and penis. 17 The pseudoangiosarcomatous pattern has also been described in poorly differentiated and sarcomatoid ductal carcinoma of the breast.…”

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confidence: 99%

Pseudoangiosarcomatous Urothelial Carcinoma of the Urinary Bladder

Paner

Cox

Richards

et al. 2014

American Journal of Surgical Pathology

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The pseudoangiosarcomatous pattern has been described mostly in cutaneous and some visceral squamous cell carcinomas and is unique for its striking morphologic resemblance to angiosarcoma. Herein, we describe the clinicopathologic features of 7 pseudoangiosarcomatous urothelial carcinomas that occurred in the urinary bladder. The patients included 6 men and 1 woman ranging in age from 47 to 87 years (median 70 y). The pseudoangiosarcomatous morphology was observed in 7 urothelial carcinomas including 3 with squamous differentiation and comprised 35% to 85% of the invasive tumor. Histologically, the pseudoangiosarcomatous carcinomas were characterized by tumor cell discohesion and lysis that created pseudolumina formations surrounded by attached residual tumor cells. Detached degenerating tumor cells variably admixed with inflammatory cells were common in the false lumina. Partly intact urothelial carcinoma nests contained irregular or cleft-like spaces and disintegrating tumor cells with stretched intercellular bridges. The tumor was commonly associated with a dense collagenous matrix, often surrounding the lytic nests. Similar tumor cell discohesion and breakdown were observed in 3 tumors with foci of squamous cell differentiation, distinguished by the presence of dyskeratosis and keratin formation. All 7 tumors contained other nonpseudoangiosarcomatous carcinoma components such as conventional urothelial carcinoma (5), squamous differentiation (4), sarcomatoid spindle cell carcinoma (2), small cell carcinoma (1), micropapillary carcinoma (1), and glandular differentiation (1). The pseudoangiosarcomatous urothelial carcinomas were all (7/7) diffusely CK7 positive, most (6/7) were GATA3 positive, and none (0/7) expressed vascular-associated markers. There was no evidence to suggest that apoptosis (by TUNEL assay and cleaved caspase-3 immunostaining) or loss of the adhesion molecules CD138 and e-cadherin were possible causes for the tumor cell discohesion and breakdown. All 7 tumors were high stage at cystectomy and included 1 pT3a, 2 pT3b, and 4 pT4a tumors, and 3 had pelvic lymph node involvement. Follow-up data available in 6 cases revealed a poor outcome with an overall median survival of 8.5 months. In conclusion, we present an unusual morphology of bladder carcinoma that has a striking resemblance to a malignant vasoformative tumor. Our series showed that bladder pseudoangiosarcomatous carcinoma morphology is associated with a higher tumor stage at cystectomy, commonly admixed with other aggressive carcinoma variant morphologies, and portend a poorer outcome. Knowledge of this pattern is also important to avoid misdiagnosis, particularly in limited tissue samples.

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“…26 One case of vulvar acantholytic squamous cell carcinoma expressed p16 protein, suggesting that this neoplasm could be related to human papillomavirus infection. 27 The prognosis for PSCC tumours is extremely poor.…”

Section: Discussionmentioning

confidence: 99%

Pseudoangiosarcomatous Squamous Cell Carcinoma of the Lung

et al. 2011

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Pulmonary pseudoangiosarcomatous squamous cell carcinoma (PSCC) is a rare aggressive variant of squamous cell carcinoma. Histopathologically, PSCC is characterized by interanastomosing cords and channels, lined by atypical cells, with spaces containing erythrocytes or floating tumour cells. PSCC mimics angiosarcoma, so careful attention should be paid to immunohistochemical differences. Two PSCC cases are described here: in a 79-year-old male, bronchoscopy revealed mucosal swelling and hypertrophy and an adrenal mass was found 1 month later; in a 76-year-old male, computed tomography revealed rib destruction due to a non-calcified softtissue tumour and, although the tumour resembled an angiosarcoma, endothelial markers were negative and cytokeratin and p63 markers were positive. Immunohisto chemical analyses may be helpful in establishing an accurate diagnosis. PSCC had a progressive course in both patients, who died ≤ 3 months postdiagnosis.

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Vulvar Acantholytic Squamous Carcinoma: A Case Report With Immunohistochemical and Molecular Study

Cited by 17 publications

References 12 publications

Metastatic submandibular acantholytic squamous cell carcinoma in a dog

Metastatic submandibular acantholytic squamous cell carcinoma in a dog

Pseudoangiosarcomatous Urothelial Carcinoma of the Urinary Bladder

Pseudoangiosarcomatous Squamous Cell Carcinoma of the Lung

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