Pseudoangiosarcomatous Squamous Cell Carcinoma of the Lung

Abstract

Pulmonary pseudoangiosarcomatous squamous cell carcinoma (PSCC) is a rare aggressive variant of squamous cell carcinoma. Histopathologically, PSCC is characterized by interanastomosing cords and channels, lined by atypical cells, with spaces containing erythrocytes or floating tumour cells. PSCC mimics angiosarcoma, so careful attention should be paid to immunohistochemical differences. Two PSCC cases are described here: in a 79-year-old male, bronchoscopy revealed mucosal swelling and hypertrophy and an adrenal mass was found 1 month later; in a 76-year-old male, computed tomography revealed rib destruction due to a non-calcified softtissue tumour and, although the tumour resembled an angiosarcoma, endothelial markers were negative and cytokeratin and p63 markers were positive. Immunohisto chemical analyses may be helpful in establishing an accurate diagnosis. PSCC had a progressive course in both patients, who died ≤ 3 months postdiagnosis.

Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report

“…From our literature review, 9 cases of pulmonary SQCC with discohesive tumor nests, including our case, have been reported (Table 1 ) [ 10 – 15 ]. The mean patient age was 63 (range, 47–79) years and the male to female ratio was 8 to 1.…”

“…The mean patient age was 63 (range, 47–79) years and the male to female ratio was 8 to 1. Seven cases showed pseudovascular or pseudoangiosarcomatous features [ 12 – 15 ], corresponding to PSQCC of the skin [ 1 ]. In PSQCC of the lung, metastasis was present in 5 of 7 cases, and blood-borne metastasis was noted rather than lymphogenous metastasis.…”

“…This is due to the sites of metastasis including the opposite lung, liver, bones, and adrenal glands, but not the lymph nodes [ 13 , 15 ]. The prognosis of pulmonary PSQCC appears to be poor since 5 of the 7 patients died within 3 years of their diagnosis [ 13 , 15 ]; the survival of the remaining 2 patients was unreliable due to a follow-up period of only 1 year [ 12 , 14 ]. In contrast, only 1 case of pulmonary ASQCC has been reported [ 10 , 11 ].…”

“…Among primary lung cancer reports, 8 cases of SQCC with marked acantholytic changes have been reported, including 1 case of ASQCC [ 10 , 11 ] and 7 cases of PSQCC [ 12 – 15 ]. Most pulmonary PSQCC cases showed poor prognoses, but the clinical course and biological behavior of pulmonary ASQCC has not been previously reported.…”

The Effect of Lymphangitis Carcinomatosa on the Stage, and Survival in the Primary Lung Cancers

“…Skuamöz hüceli karsinomun nadir görülen farklı bir alt türü olan akantolizli skuamöz hücreli karsinomlarda görülen LK ile ilgili literatürde 9 olgu bildirilmiş ve bu olgularda prognozun kötü olduğu belirtilmiştir. [24][25][26][27][28][29][30] Bizim serimizde en sık LK'ya neden olan histopatolojik tip skuamöz hücreli kanserlerdi. Literatürde primer akciğer skuamöz hücreli kanser tanısı alıp LK tespit edilen bir olguya ulaşıldı.…”