Vulval squamous cell carcinoma arising in chronic hidradenitis suppurativa

Short, K. A.; Kalu, G.; Mortimer, P. S.; Higgins, E. M.

doi:10.1111/j.1365-2230.2005.01875.x

Cited by 39 publications

(18 citation statements)

References 5 publications

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“…Other investigators have highlighted the fact that this inflammatory lesion can occur in patients with long-standing Crohn's disease, and have reported a case of chronic HS complicated by a vulval squamous cell carcinoma [181]. Finally, Maclean et al, referring to advanced cases of squamous cell carcinoma (SCC) arising in chronic HS, have advocated that HS arising in extra-axillary sites is a pre-malignant condition [182].…”

Section: Hidradenitis Suppurativa (Hs) and Cancer Developmentmentioning

confidence: 99%

Chronic bacterial and parasitic infections and cancer: a review

Samaras

Rafailidis

Mourtzoukou

et al. 2010

J Infect Dev Ctries

111

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Background: A relatively underestimated facet of infectious diseases is the association of chronic bacterial and parasitic infections with cancer development. Therefore, we sought to evaluate the evidence regarding the association of such infections with the development of malignancy, excluding the overwhelming evidence of the association of Helicobacter pylori and cancer. Methodology: We searched Pubmed, Cochrane, and Scopus without time limits for relevant articles. Results: There is evidence that some bacterial and parasitic infections are associated with cancer development. The level of evidence of this association varies from high to low; in any case, a long time interval is mandatory for the development of cancer. A high level of evidence exists for the association of Salmonella Typhi with gallbladder and hepatobiliary carcinoma; Opisthorchis viverrini and Clonorchis sinensis with cholangiocarcinoma; Schistosoma hematobium with bladder cancer; chronic osteomyelitis with squamous cell carcinoma of the skin; and hidradenitis suppurativa with squamous cell carcinoma of the skin. In contrast, the level of evidence regarding the association of Chlamydia spp. with cancer is low. Mycobacterium tuberculosis is associated with lung cancer, albeit probably not etiopathogenetically. Conclusions: A considerable number of bacterial infections and parasitic infections are associated with the development of cancer. Further research into recognizing additional associations of bacterial and parasitic infections with cancer is mandatory.

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Section: Hidradenitis Suppurativa (Hs) and Cancer Developmentmentioning

confidence: 99%

Chronic bacterial and parasitic infections and cancer: a review

Samaras

Rafailidis

Mourtzoukou

et al. 2010

J Infect Dev Ctries

111

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“…In addition to scarring, SCC has been reported in longstanding disease (Short et al 2005), and one case of squamous cell carcinoma with hidradenitis was associated with a paraneoplastic neuropathy (Rosenzweig et al 2005). Verrucous carcinomas have also been described (Cosman et al 2000), and one case of clear cell acanthoma (Zedek et al 2007).Other complications in severe disease include anaemia, arthropathy, urethral fistula and amyloidosis (Montes-Romero et al 2008).…”

Section: Complicationsmentioning

confidence: 99%

Non‐Infective Cutaneous Conditions of the Vulva

Neill

Lewis

2009

Ridley's the Vulva

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“…Although distant metastasis is generally rare in SCC secondary to HS, metastatic sites reported in the literature include the axial skeleton, abdominopelvic viscera, peritoneum, vulva, and lung parenchyma [1,4,8]. In our patient, the metastatic disease was to the pleura.…”

Section: Discussionmentioning

confidence: 74%

Metastatic Squamous Cell Carcinoma of the Pleura: A Rare Complication of Hidradenitis Suppurativa

et al. 2016

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Patient: Male, 46Final Diagnosis: Metastatic squamous cell carcinomaSymptoms: Short of breathMedication: —Clinical Procedure: Pleural biopsySpecialty: OncologyObjective:Rare diseaseBackground:Squamous cell carcinoma (SCC), also known as Marjolin ulcer, is a rare complication of hidradenitis suppurativa (HS). Metastatic SCC from HS typically involves the axial skeleton or abdominopelvic viscera. Metastatic disease to the lungs is a rare phenomenon with only three reported cases of lung parenchyma. We present a biopsy proven case of metastatic SCC to the pleura from gluteal HS.Case Report:A 46-year-old male with a history of recently diagnosed Marjolin ulcer secondary to gluteal HS was transferred to our intensive care unit for acute hypoxemic respiratory failure secondary to recurrent pleural effusion. On examination, patient was febrile (38.3°C), normotensive (blood pressure 98/65 mm Hg), tachycardic (116 beats/minute) and tachypneic (40 breaths/minute) with oxygen saturation of 93% on room air. He was in moderate distress requiring endotracheal intubation and mechanical ventilation. Chest examination revealed decreased breath sounds bilaterally and skin examination was significant for 18 cm wide sacral lesion. CT thorax showed bilateral pleural effusions, pleural thickening, and scattered nodular densities within both lungs concerning for metastatic disease. Thoracentesis showed lymphocyte predominant exudate with negative cytology for malignant cells. A video-assisted thoracoscopic surgery (VATS) illustrated thickened pleural rind with histopathology and positive p40 stain consistent with invasive well-to-moderately differentiated keratinizing SCC.Conclusions:SCC arising from HS is rare and metastatic disease to the pleura has not been reported previously. Strong clinical suspicion for malignancy is warranted in patients with advanced HS and evolving pulmonary symptoms despite negative cytology.

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Vulval squamous cell carcinoma arising in chronic hidradenitis suppurativa

Cited by 39 publications

References 5 publications

Chronic bacterial and parasitic infections and cancer: a review

Chronic bacterial and parasitic infections and cancer: a review

Non‐Infective Cutaneous Conditions of the Vulva

Metastatic Squamous Cell Carcinoma of the Pleura: A Rare Complication of Hidradenitis Suppurativa

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