Chronic bacterial and parasitic infections and cancer: a review

Samaras, Vassilis; Rafailidis, Petros I.; Mourtzoukou, Eleni G.; Peppas, George; Falagas, Matthew E.

doi:10.3855/jidc.819

Cited by 111 publications

(71 citation statements)

References 142 publications

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“…Currently, approximately a quarter of the worldwide malignancies are attributed to microbial contribution [18] and orodigestive cancers are among the top five leading causes of cancer mortalities [16]. One of the particularly devastating examples of orodigestive cancer mortality with escalating prevalence is oral squamous cell carcinoma (OSCC), which claims an estimated 7500 lives yearly in the United States [19].…”

Section: Cancer and Oral Microbesmentioning

confidence: 99%

Prelude to oral microbes and chronic diseases: past, present and future

Atanasova

Yılmaz

2015

Microbes and Infection

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Associations between oral and systemic health are ancient. Oral opportunistic bacteria, particularly, Porphyromonas gingivalis and Fusobacterium nucleatum, have recently been deviated from their traditional roles and arguably ascended to central players based on their participations in complex co-dependent mechanisms of diverse systemic chronic diseases risk and pathogenesis, including cancers, rheumatoid-arthritis, and diabetes.

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Section: Cancer and Oral Microbesmentioning

confidence: 99%

Prelude to oral microbes and chronic diseases: past, present and future

Atanasova

Yılmaz

2015

Microbes and Infection

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“…The incidence of and mortality associated with CC are increasing worldwide and an etiological study found that the daily ingestion of germs, including Helicobacter spp., and parasites might contribute to the development of CC (Samaras, et al 2010). Liossi et al found 17β-estradiol (E2), but not testosterone, immunoactivity in CC lesions (Liossi, et al 1988), suggesting potential protective/redundant roles of male hormones in CC progression (Liossi et al 1988).…”

Section: Part II Androgen/ar Signaling In Liver Cancermentioning

confidence: 99%

Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis

Lung¹,

Lai²,

Yeh³

et al. 2014

Endocrine-Related Cancer

141

114

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Summary Androgen/androgen receptor (AR) signaling plays important roles in normal liver function and in progression of liver diseases. In studies of non-cancerous liver diseases, AR knockout mouse models of liver disease have revealed that androgen/AR signaling suppresses the development of steatosis, virus-related hepatitis, and cirrhosis. In addition, studies have shown that targeting AR in bone marrow-derived mesenchymal stem cells (BM-MSCs) improves their self-renewal and migration potentials, thereby increasing the efficacy of BM-MSC transplantation as a way to control the progression of cirrhosis. Androgen/AR signaling is known to be involved in the initiation of carcinogen- or Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). However, studies have demonstrated that AR, rather than androgen, plays the dominant role in cancer initiation. Therefore, targeting AR might be an appropriate therapy for patients with early-stage HCC. In contrast, androgen/AR signaling has been shown to suppress metastasis of HCC in patients with late-stage disease. In addition, there is evidence that therapy comprising Sorafenib and agents that enhance the functional expression of AR may suppress the progression of late-stage HCC.

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“…Nevertheless, contribution of bacterial infection to cancer development has been suggested based on various epidemiological studies (Mager, 2006;Samaras et al, 2010). Most accepted is the link between Helicobacter pylori and gastric cancer (Polk and Peek, 2010).…”

Section: Introductionmentioning

confidence: 99%

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma

Scanu

Spaapen

Bakker

et al. 2015

Cell Host & Microbe

209

213

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Cancer is fueled by deregulation of signaling pathways in control of cellular growth and proliferation. These pathways are also targeted by infectious pathogens en route to establishing infection. Gallbladder carcinoma (GBC) is frequent in the Indian subcontinent, with chronic Salmonella enterica serovar Typhi infection reported as a significant risk factor. However, direct association and causal mechanisms between Salmonella Typhi infection and GBC have not been established. Deconstructing the epidemiological association between GBC and Salmonella Typhi infection, we show that Salmonella enterica induces malignant transformation in predisposed mice, murine gallbladder organoids, and fibroblasts, with TP53 mutations and c-MYC amplification. Mechanistically, activation of MAPK and AKT pathways, mediated by Salmonella enterica effectors secreted during infection, is critical to both ignite and sustain transformation, consistent with observations in GBC patients from India. Collectively, our findings indicate that Salmonella enterica can promote transformation of genetically predisposed cells and is a causative agent of GBC.

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Chronic bacterial and parasitic infections and cancer: a review

Cited by 111 publications

References 142 publications

Prelude to oral microbes and chronic diseases: past, present and future

Prelude to oral microbes and chronic diseases: past, present and future

Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma

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