Vulnérabilité au Trouble Bipolaire: La Piste de la Vitamine D

Naifar, Manel; Bouali, M. Mâalej; Guidara, Wassim; Ellouze, Ahmed Slim; Jmal, K.; Omri, S.; Messedi, Meriam; Zouari, L.; Elleuch, Aïda; Maâlej, M.; Chaabouni, Khansa; Charfi, N.; Turki, Mouna; Thabet, J. Ben; Ayadi, Fatma

doi:10.1177/0706743719870513

Cited by 8 publications

(5 citation statements)

References 43 publications

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“…One study comprising 118 participants found that patients with BD were 470% more likely to be de icient in vitamin D than the general population [124]. In contrast, one cross-sectional study found plasma 25-hydroxy vitamin D levels to be higher in patients with BD who were in a state of decompensation than in healthy controls [125]. There is evidence to suggest that vitamin D supplements may reduce symptoms of depression and mania, although further research is required to determine clinically effective dosages [126][127][128].…”

Section: Bipolar Disorder and Nutrientsmentioning

confidence: 99%

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Madireddy¹,

Madireddy²

2022

J Neurosci Neurol Disord

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Neurological disorders are a significant cause of mortality and disability across the world. The current aging population and population expansion have seen an increase in the prevalence of neurological and psychiatric disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis and schizophrenia. These pose a significant societal burden, especially in low - and middle-income countries. Many neurological disorders have complex mechanisms and lack definitive cures; thus, improving our understanding of them is essential. The pathophysiology of neurological disorders often includes inflammation, mitochondrial dysfunction and oxidative stress. Oxidative stress processes, especially the generation of reactive oxygen species, are key mechanisms in the development of neurological disorders. Oxidative stress refers to an imbalance between the production of reactive oxygen species and antioxidants that can counteract them. Through their impacts on the pathophysiology of neurological disorders, nutrients with anti-inflammatory, neuroprotective and antioxidative properties have been suggested to prevent or mitigate these disorders. Certain vitamins, minerals, polyphenols and flavonoids may have therapeutic effects as adjuvant treatments for neurological disorders. Diet quality is also a risk factor for some neurological and psychiatric disorders and addressing nutritional deficiencies may alleviate symptoms. Therefore, optimizing nutritional intake may represent a potential treatment or prevention strategy. This review summarizes a selection of promising nutrients for the prevention and amelioration of neurological disorders to provide a summary for scientists, clinicians and patients, which may improve understanding of the potential benefits of nutrients in the treatment of neurological disorders.

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Section: Bipolar Disorder and Nutrientsmentioning

confidence: 99%

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Madireddy¹,

Madireddy²

2022

J Neurosci Neurol Disord

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“…Recent studies have shown that there might be a link between bipolar disorder and vitamin D deficiency [53]. There is little information concerning vitamin D levels and supplementation effects on the course of bipolar disorder; however, there has been a noted increase in 25OHD synthesis during BD decompensation [54]. Other studies have shown a lower level of vitamin D in people with bipolar disorders, but supplementation was not correlated with an improvement in depressive symptoms [55].…”

Section: Bipolar Disordersmentioning

confidence: 99%

“…Receptor-1,25(OH)2D3 antagonizing the effects of the glucocorticoid on hippocampal neurons [59] Lower level of serum Vitamin D is caused by long periods of institutionalization, inactivity, and, therefore, less exposure to sunlight [49] Bipolar disorders Increased 25OHD synthesis during decompensation [54] Lower level of Vitamin D in depressive patients [55] Depression Mechanisms implied are exerting influence on neuroendocrine, immunological, and neurotrophic systems [59] Receptors are localized in the hypothalamus [124] Table 1. Cont.…”

Section: Psychotic Spectrum Diseasesmentioning

confidence: 99%

Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

Ciobanu,

Petrescu,

Anghele

et al. 2023

Medicina

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In the last few years, vitamin D functions have been studied progressively, and along with their main role in regulating calcium homeostasis, the potential function in the nervous system and the link between different psychiatric disorders and vitamin D deficiency have been revealed. The discovery of vitamin D receptors in multiple brain structures, like the hippocampus, led to the hypothesis that vitamin D deficiency could be responsible for treatment resistance in psychiatric diseases. The aim of this study was to analyze the current knowledge in the literature regarding vitamin D deficiency among individuals afflicted with psychiatric disorders and assess the potential therapeutic benefits of vitamin D supplementation. A systematic search was conducted on the PubMed database for articles published in the last five years (2016–2022) in English, focusing on human subjects. Results show that vitamin D deficiency has implications for numerous psychiatric disorders, affecting mood and behavior through its influence on neurotransmitter release, neurotrophic factors, and neuroprotection. It also plays a role in modulating inflammation, which is often elevated in psychiatric disorders. In conclusion, vitamin D deficiency is prevalent and has far-reaching implications for mental health. This review underscores the importance of exploring the therapeutic potential of vitamin D supplementation in individuals with psychiatric disorders and highlights the need for further research in this complex field.

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“…19,20 Therefore, the anti-inflammatory neuroprotective role of vitamin D may preserve axonal integrity in the face of neurodamage, which can be identified as neurofilament light chain (NfL) levels. 10,21 The NfL is a unique biomarker related to axonal damage and neural cell death. It demonstrates promise as a potential marker of neuropsychiatric disease activity and progression associated with cognitive deficit.…”

Section: 4mentioning

confidence: 99%

The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder

Chen

Huang²,

Chiu³

et al. 2022

BJPsych open

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Background Bipolar disorder is a chronic mental disorder related to cognitive deficits. Low serum vitamin D levels are significantly associated with compromised cognition in neuropsychiatric disorders. Although patients with bipolar disorder frequently exhibit hypovitaminosis D, the association between vitamin D and cognition in bipolar disorder, and their neuroaxonal integrity, is unclear. Aims To investigate the interaction effects between vitamin D and neurofilament light chain (NfL) levels on cognitive domains in bipolar disorder. Method Serum vitamin D and NfL levels were determined in 100 euthymic patients with bipolar disorder in a cross-sectional study. Cognitive function was measured with the Brief Assessment of Cognition in Affective Disorders. We stratified by age groups and used general linear models to identify associations between vitamin D and NfL levels and their interaction effects on cognitive domains. Results The mean vitamin D and NfL levels were 16.46 ng/nL and 11.10 pg/mL, respectively; 72% of patients were vitamin D deficient. In the older group, more frequent hospital admissions and lower physical activity were identified in the group with versus without vitamin D deficiency. The age-modified interaction effect of vitamin D and NfL was associated with composite neurocognitive scores and verbal fluency in both age groups, and with processing speed domain in the younger group. Conclusions We observed a high vitamin D deficiency prevalence in bipolar disorder. We identified the interaction of vitamin D and NfL on cognitive domains, and the effect was modified by age. Longitudinal or randomised controlled studies enrolling patients with various illness durations and mood statuses are required to validate our findings.

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Vulnérabilité au Trouble Bipolaire: La Piste de la Vitamine D

Cited by 8 publications

References 43 publications

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder

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