Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Madireddy, Sahithi; Madireddy, Samskruthi

doi:10.29328/journal.jnnd.1001070

Cited by 3 publications

(1 citation statement)

References 355 publications

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“…Through such interactions, dietary interventions may influence related pathophysiological processes, including increased oxidative stress, metabolism disruption, and neuroinflammation, while improving the outcome of certain chronic neurological disorders. Indeed, some nutritional interventions are increasingly appreciated as contributing to the prevention and treatment of neurological disorders (18,128). Other nutritional bioactive molecules, including vitamins, polyphenols, flavonoids, minerals, and the ketogenic diet, may be efficient as adjuvant treatment in such disorders (62,64,200).…”

Section: Discovery Of Dietary Molecules For Targeted Therapiesmentioning

confidence: 99%

The Role of Artificial Intelligence in Deciphering Diet–Disease Relationships: Case Studies

2023

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Modernization of society from a rural, hunter-gatherer setting into an urban and industrial one, with the associated dietary changes, has led to an increased prevalence of cardiometabolic and additional noncommunicable diseases, such as cancer, inflammatory bowel disease, and neurodegenerative and autoimmune disorders. However, while dietary sciences have been rapidly evolving to meet these challenges, validation and translation of experimental results into clinical practice remain limited for multiple reasons, including inherent ethnic, gender, and cultural interindividual variability, among other methodological, dietary reporting–related, and analytical issues. Recently, large clinical cohorts with artificial intelligence analytics have introduced new precision and personalized nutrition concepts that enable one to successfully bridge these gaps in a real-life setting. In this review, we highlight selected examples of case studies at the intersection between diet–disease research and artificial intelligence. We discuss their potential and challenges and offer an outlook toward the transformation of dietary sciences into individualized clinical translation. Expected final online publication date for the Annual Review of Nutrition, Volume 43 is August 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: Discovery Of Dietary Molecules For Targeted Therapiesmentioning

confidence: 99%

The Role of Artificial Intelligence in Deciphering Diet–Disease Relationships: Case Studies

2023

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Neurological disorders: The use of traditional medicine in Cameroon

Gamo,

Djiogue,

Awounfack

et al. 2024

Tradit. Med. Mod. Med.

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Neurological disorders constitute 6.3% of the global disease burden in the world. With a global death rate of 12%, these diseases are an important cause of mortality. The burden of neurological disorders is higher in developing countries than in developed countries. However, there is little literature on neurological diseases in sub-Saharan Africa, including Cameroon. Due to the inadequate access to modern medicine and physicians, the high cost, and the side effects of the modern drugs, patients renounced treatment. Traditional medicine is thus presented as an alternative. The World Health Organization reports that about 75–80% of the population of developing countries, mostly in Africa, consult traditional healers and use traditional medicine for their healthcare. In Cameroon, traditional medicines still remain a major source for preventing, diagnosing, and/or treating several household diseases, including neurological disorders. This review analyzes the prevalence of neurological disorders in Cameroon, the ethnobotanical knowledge of medicinal plants used to manage nervous system disorders or symptoms, and the importance of pharmacological studies. Some studies done in hospitals located in two towns of Cameroon (Yaoundé and Douala) show that the main neurological disorders are headache and epilepsy. To manage these neurological disorders, many plants are used by traditional doctors and the population. In recent years, some researchers from different university laboratories of Cameroon have tried to elucidate the beneficial effects of plant extracts on neurological disorders, and more is still to be done to prove the pharmacological effects of traditional medicine on nervous system diseases.

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Therapeutic Strategies to Ameliorate Neuronal Damage in Epilepsy by Regulating Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation

Madireddy

2023

Brain Sciences

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Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures that affects 50 million individuals globally. Because approximately one-third of patients with epilepsy do not respond to drug therapy, the development of new therapeutic strategies against epilepsy could be beneficial. Oxidative stress and mitochondrial dysfunction are frequently observed in epilepsy. Additionally, neuroinflammation is increasingly understood to contribute to the pathogenesis of epilepsy. Mitochondrial dysfunction is also recognized for its contributions to neuronal excitability and apoptosis, which can lead to neuronal loss in epilepsy. This review focuses on the roles of oxidative damage, mitochondrial dysfunction, NAPDH oxidase, the blood–brain barrier, excitotoxicity, and neuroinflammation in the development of epilepsy. We also review the therapies used to treat epilepsy and prevent seizures, including anti-seizure medications, anti-epileptic drugs, anti-inflammatory therapies, and antioxidant therapies. In addition, we review the use of neuromodulation and surgery in the treatment of epilepsy. Finally, we present the role of dietary and nutritional strategies in the management of epilepsy, including the ketogenic diet and the intake of vitamins, polyphenols, and flavonoids. By reviewing available interventions and research on the pathophysiology of epilepsy, this review points to areas of further development for therapies that can manage epilepsy.

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Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Cited by 3 publications

References 355 publications

The Role of Artificial Intelligence in Deciphering Diet–Disease Relationships: Case Studies

The Role of Artificial Intelligence in Deciphering Diet–Disease Relationships: Case Studies

Neurological disorders: The use of traditional medicine in Cameroon

Therapeutic Strategies to Ameliorate Neuronal Damage in Epilepsy by Regulating Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation

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