Voriconazole-Natural Latex Dressings for Treating Infected Candida Spp. Skin Ulcers

Abstract

Aim: This work aimed to develop a membrane based on voriconazole (VCZ)-loaded natural rubber latex (NRL) for treating infected ulcers with Candida spp. and study their interaction, drug release, antifungal activity against Candida parapsilosis and biological characterization. Materials & methods: VCZ-loaded NRL membrane was produced by casting method. Results: Infrared spectrum showed that the incorporation of VCZ into the NRL membrane maintained its characteristics. Its mechanical properties were considered suitable for dermal application. The VCZ was able to release from NRL membrane, maintaining its antifungal activity against C. parapsilosis, besides did not present hemolytic effects. Conclusion: The VCZ-NRL membrane showed good results in mechanical, antifungal and biological assays, representing an interesting alternative to treatment of infected wound with Candida spp.

Silver nanoparticles effect on drug release of metronidazole in natural rubber latex dressing

“…Thus, we verified that none of the materials caused damage to the erythrocyte membrane within 24 h after application, corroborating with the results obtained by Barros et al [66], Morise et al [67], Silva et al [28] and Cesar et al [68], who tested the hemolytic activity of NRL membranes with oxytocin, scopolamine, voriconazole and polylactic acid, respectively, and also obtained values lower than 5%.…”

“…A promising alternative that has been studied is the use of natural rubber latex (NRL) as a carrier for NPs and bioactive compounds [22][23][24][25][26][27][28][29]. NRL is a colloidal system containing 50% water, 4-5% non-rubber (proteins, lipids and carbohydrates) and 30-45% rubber particles (cis-1,4-polyisoprene) [29].…”

Glycerol and Antimicrobial Peptide-Modified Natural Latex for Bacteriostasis of Skin Wounds

“…Before adding GI and the AMP, the surface of the NRL film is smooth, compact, and without obvious pores (Figure A), which is consistent with the result of Silva et al that there are no pores on the surface of the NRL film. Figure B,C shows the SEM images of NRL-GI and NRL-GI-AMP films, respectively.…”

“…The ideal drug carrier is that the drug contained in it can be released slowly and exerts corresponding pharmacological effects. For example, NRL dressings loaded with voriconazole, which can release voriconazole slowly and efficiently, are used in the treatment of skin ulcers with candida infection . It can be seen from Figure that the NRL-GI film had no inhibitory effect on E.…”

“…For example, NRL dressings loaded with voriconazole, which can release voriconazole slowly and efficiently, are used in the treatment of skin ulcers with candida infection. 41 It can be seen from Figure 5 that the NRL-GI film had no inhibitory effect on E. coli and S. aureus and did not produce an inhibition zone, while the NRL-GI-AMP film had the inhibition zone with different sizes against E. coli and S. aureus. It can be proved that AMP can be effectively released from the NRL-GI-AMP film to exert its antibacterial activity.…”