von Willebrand’s disease

Gopegui, Rafael Ruiz de; Feldman, Bernard F.

doi:10.1007/bf02658688

Cited by 7 publications

(6 citation statements)

References 82 publications

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“…One of the dogs in this report showed severe thrombocytopenia without any obvious clinical signs of haemorrhage such as petechiation, ecchymosis and/or purpura 2 . The most likely cause for the thrombocytopenia in this dog was platelet sequestration, which is frequently associated with splenic-and/or hepatomegaly 2 . The possibility also exists that this dog had concurrent IMHA and immune-mediated thrombocytopenia (IMT), which has been described as Evans' syndrome 8 .…”

Section: Discussionmentioning

confidence: 63%

Immune-mediated haemolytic anaemia : possible association with Ancylostoma caninum infection in three dogs : case report

Lobetti

Schoeman²

2001

J. S. Afr. Vet. Assoc.

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Immune-mediated haemolytic anaemia (IMHA) may be primary or secondary. In primary IMHA, no underlying cause can be found, whereas secondary IMHA is triggered by an underlying cause, such as neoplasia, infectious diseases, or drugs. This paper describes 3 dogs with typical signs of IMHA that was possibly associated with the intestinal parasite <em>Ancylostoma caninum</em>. As intestinal helminths can be difficult to diagnose on faecal examination, it would be pertinent to performmultiple faecal examinations on any animal that has IMHA with no apparent underlying cause, as part of the therapy

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Section: Discussionmentioning

confidence: 63%

Immune-mediated haemolytic anaemia : possible association with Ancylostoma caninum infection in three dogs : case report

Lobetti

Schoeman²

2001

J. S. Afr. Vet. Assoc.

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“…vWD is a unique disorder that was described originally by Erik von Willebrand in 1926. 53 This disorder is usually transmitted as an autosomal dominant trait with varying penetrance. The defect is found in the F VIII protein complex.…”

Section: Factors XIII and I Deficienciesmentioning

confidence: 99%

Bleeding and Clotting Disorders

Napeñas¹,

Patton²

2021

Burket's Oral Medicine

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Dental health care workers are increasingly called upon to provide quality dental care to individuals whose bleeding and clotting mechanisms have been altered by inherited or acquired diseases. This provides an opportunity for the dentist who is trained in the recognition of oral and systemic signs of altered hemostasis to assist in the diagnosis of the underlying condition. A number of dental procedures result in the risk of bleeding that can have serious consequences, such as severe hemorrhage or possibly death, for the patient with a bleeding disorder. Safe dental care may require consultation with the patient's physician, systemic management, and dental treatment modifications.Of the inherited coagulopathies, von Willebrand's disease (vWD) is the most common. It results from deficiency of von Willebrand's factor (vWF) and affects about 0.8 to 1% of the population. 1 Hemophilia A, caused by coagulation factor (F) VIII deficiency, is the next most common, followed by hemophilia B, a F IX deficiency. The age-adjusted prevalence of hemophilia in six surveillance states in 1994 was 13.4 cases in 100,000 males (10.5 for hemophilia A and 2.9 for hemophilia B). 2 Application to the US population resulted in an estimated national prevalence of 13,320 cases of hemophilia A and 3,640 cases of hemophilia B, with an incidence rate of 1 per 5,032 live male births. Hemophilia A was predominant, accounting for 79% of all hemophiliacs, and prevalence of disease severity was 43% severe (< 1% F VIII), 26% moderate (1-5% F VIII), and 31% with mild (6-30% F VIII) disease. 2 Acquired coagulation disorders can result from drug actions or side effects, or underlying systemic disease. A stratified household sample of 4,163 community residents aged 65 years or older living in a five-county area of North Carolina revealed 51.7% to be taking one or more medications (aspirin, warfarin, dipyridamole, nonsteroidal anti-inflammatory drugs

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“…1,2 vWd is the most common congenital bleeding disorder of dogs and humans. 3,4 It is recognized in more than 25 dog breeds, as well as in mixed breed dogs. 5,6 Type 1 vWd involves a quantitative decrease in vWf with a normal multimeric pattern and affects many breeds, including the Doberman Pinscher, in which the prevalence of vWd is as high as 70%.…”

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confidence: 99%

“…3 Definitive diagnosis of type 1 vWd is based on the findings of low, but detectable, plasma vWf : Ag (values from 1 to 49%), with equivalent values of vWf functional activity and a normal vWf multimer composition. 1,4,11 In this subtype, dogs with a vWf : Ag Ͻ30% generally are considered at increased risk for expression of a bleeding diathesis. 2,4,12 Treatment options for vWd are limited, and those available increase plasma vWf concentration only transiently.…”

mentioning

confidence: 99%

“…1,4,11 In this subtype, dogs with a vWf : Ag Ͻ30% generally are considered at increased risk for expression of a bleeding diathesis. 2,4,12 Treatment options for vWd are limited, and those available increase plasma vWf concentration only transiently. Desmopressin (1-desamino-8-D-arginine vasopressin or DDAVP) is believed to release intracellular stores of vWf, but marked variation occurs in response to this drug.…”

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confidence: 99%

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Effect of Levothyroxine Administration on Hemostatic Analytes in Doberman Pinschers with von Willebrand Disease

et al. 2005

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Levothyroxine administration has been suggested to be an effective treatment for canine von Willebrand disease (vWd), but evidence supporting this treatment is lacking. Effects of levothyroxine administration were evaluated in 8 euthyroid Doberman Pinschers with plasma von Willebrand factor (vWf) concentrations < 15%, characteristic of type 1 vWd. Levothyroxine (0.04 mg/kg PO q12h) and placebo were administered for 30 days in a 2-period, 2-treatment, double-blinded, crossover design with a 30-day washout period between treatments. Buccal mucosal bleeding time (BMBT), plasma vWf concentration (vWf: Ag), vWf collagen binding activity (vWf:CBA), factor VIII coagulant activity (FVIII:C), and serum concentrations of total thyroxine (T4), free thyroxine (fT4), 3,5,3'-triiodothyronine (T3), and thyroid-stimulating hormone (TSH) were measured on days 0, 2, and 30 of each treatment period. The 8 dogs (1 male, 7 females) had markedly low plasma vWf:Ag (mean, 8.9%; reference range, 70-180%) and vWf:CBA (mean, 11.1%; reference range, >70%). Response to placebo versus levothyroxine treatment was not significantly different between groups at day 0, 2, or 30 for BMBT, vWf:Ag, vWf:CBA, and FVIII:C. Serum T4, fT4, and T3 concentrations were significantly higher and serum TSH significantly lower in the levothyroxine-treated group than in the placebo group at days 2 and 30. Administration of levothyroxine at 0.04 mg/kg caused laboratory evidence of hyperthyroidism but did not affect plasma FVIII:C and vWf:Ag concentrations or vWf-dependent collagen binding and BMBT. The results of this study failed to identify a direct action of levothyroxine supplementation on plasma vWf concentration or activity in euthyroid Doberman Pinschers with vWd.

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von Willebrand’s disease

Cited by 7 publications

References 82 publications

Immune-mediated haemolytic anaemia : possible association with Ancylostoma caninum infection in three dogs : case report

Immune-mediated haemolytic anaemia : possible association with Ancylostoma caninum infection in three dogs : case report

Bleeding and Clotting Disorders

Effect of Levothyroxine Administration on Hemostatic Analytes in Doberman Pinschers with von Willebrand Disease

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