Von Willebrand Factor And The Right Ventricle: The MESA-Right Ventricle Study

Abstract

Elevation in plasma activity of von Willebrand Factor (vWF) reflects endothelial dysfunction and predicts death in pulmonary arterial hypertension (PAH). Higher vWF activity is also associated with lower right ventricular (RV) ejection fraction in PAH. Little is known about the relationship between vWF and RV structure and function in adults without cardiovascular disease. In the current investigation, we included 1,976 participants with MRI assessment of RV structure and function and measurement of vWF activity from the Multi-Ethnic Study of Atherosclerosis. Multivariable linear regression was used to estimate the associations between vWF activity and measures of RV structure and function after adjusting for demographics, anthropometrics, smoking, diabetes mellitus, hypertension and the corresponding left ventricular (LV) parameter. The average vWF activity was 140.7 ± 57.2%. Elevated vWF activity was independently associated with lower RV mass, RV end-diastolic volume and RV stroke volume in models with and without adjustment for the corresponding LV parameter (all p < 0.05). There was no association observed between vWF activity and RV ejection fraction. In conclusion, higher vWF activity is associated with lower RV mass, RV end-diastolic volume and RV stroke volume. These associations are independent of common cardiovascular risk factors and LV morphologic changes.

Traffic-related Air Pollution and the Right Ventricle. The Multi-ethnic Study of Atherosclerosis

“…Covariables including age, sex, race/ ethnicity, height, weight, education, income, presence of hypertension or diabetes mellitus, fasting plasma glucose, cholesterol, systolic blood pressure, smoking status and pack-years, percent emphysema (obtained by chest computed tomography), and selfreported lung disease (asthma and/or emphysema) were measured as previously described (23). Because levels of air pollution within a neighborhood are correlated over time, self-reported time a participant lived in the index neighborhood (the residential neighborhood used to determine 1-year pollutant estimates) was used as a surrogate for exposure duration (8).…”

Pentraxin‐3 and the Right Ventricle: The Multi‐Ethnic Study of Atherosclerosis–Right Ventricle Study

“…Other covariables, including race/ethnicity, height, weight, presence of hypertension or diabetes mellitus, C-reactive protein (CRP), smoking status, spirometry, and emphysema, were measured as described elsewhere (see appendix, available online). 24…”

H2Receptor Antagonists and Right Ventricular Morphology: The MESA Right Ventricle Study

“…We hypothesized that H2RA use would be independently associated with lower RV mass and smaller RV end-diastolic volume (RVEDV). Some of the results of these studies have been previously reported in the form of an abstract (13).…”