Von Willebrand Disease in a Thoroughbred Mare and Foal

Identification, Management and Outcome of Postoperative Hemoperitoneum in 23 Horses After Emergency Exploratory Celiotomy for Gastrointestinal Disease

“…Another unexpected finding was an apparent over‐representation of the Thoroughbred breed in horses with postoperative hemoperitoneum compared to the population of horses presenting for colic. Whereas coagulopathies have been described in the Thoroughbred breed, there are no studies to indicate that the Thoroughbred breed is predisposed to coagulopathies compared to other breeds. There is no obvious explanation for this finding, and further study would be indicated to verify that this is not a spurious result.…”

Inherited platelet disorders

“…In contrast, VWD is rare in cats and horses . In 1 Quarter horse and in 1 Thoroughbred with VWD, the HMW multimers were decreased suggesting the presence of Type 2 VWD. Further characterization of VWD in cats and horses is lacking.…”

ADAMTS Proteases: Potential Biomarkers and Novel Therapeutic Targets for Cartilage Health

“…However, recent studies on genome-wide association analysis and transgenic animals have indicated that ADAMTS, ADAMTSL, and papilin gene mutations cause lethal embryonic defects and autosomal recessive Mendelian disorders such as human Ehlers-Danlos syndrome [32], bovine dermatosparaxis [33,34], human Weill-Marchesani syndrome [35], canine ectopia lentis [36], human Geleophysic dysplasia [37], canine Musladin-Lueke syndrome [38], and thrombotic thrombocytopenic purpura [39]. In consideration of this knowledge, ADAMTSs, ADAMTSLs, and papilin could be responsible as most commonly screened genetic disorders among horses as early embryonic death and abnormalities, junctional epidermolysis bullosa [40], hereditary equine regional dermal asthenia [41], thrombocytopenia and, von Willebrand disease [42].…”