Vomeronasal organ removal before sexual experience impairs male hamster mating behavior

Meredith, Michael

doi:10.1016/0031-9384(86)90362-8

Cited by 181 publications

(102 citation statements)

References 32 publications

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“…Deafferentation of the accessory olfactory system had variable effects, with experienced males being less affected (Meredith, 1986). Mating-induced increases in Fos-ir in the main and accessory olfactory bulbs were specific to chemosensory stimuli, rather than to mating (reviewed in Hull et al, 2006).…”

Section: The Roles Of Various Brain Areas In Male Hamster Sexual Behamentioning

confidence: 99%

Sexual behavior in male rodents

Hull

Domínguez

2007

Hormones and Behavior

392

272

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The hormonal factors and neural circuitry that control copulation are similar across rodent species, although there are differences in specific behavior patterns. Both estradiol (E) and dihydrotestosterone (DHT) contribute to the activation of mating, although E is more important for copulation and DHT for genital reflexes. Hormonal activation of the medial preoptic area (MPOA) is most effective, although implants in the medial amygdala (MeA) can also stimulate mounting in castrates. Chemosensory inputs from the main and accessory olfactory systems are the most important stimuli for mating in rodents, especially in hamsters, although genitosensory input also contributes. Dopamine agonists facilitate sexual behavior, and serotonin (5-HT) is generally inhibitory, though certain 5-HT receptor subtypes facilitate erection or ejaculation. Norepinephrine agonists and opiates have dose-dependent effects, with low doses facilitating and high doses inhibiting behavior.

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Section: The Roles Of Various Brain Areas In Male Hamster Sexual Behamentioning

confidence: 99%

Sexual behavior in male rodents

Hull

Domínguez

2007

Hormones and Behavior

392

272

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“…Indeed, the integration of the ability to mate is, in male hamsters, dependent on sexual experience and integration of vomeronasal cues with main olfactory cues [74,84]. In sexually naïve males, severe deficits in mating behavior can be observed following removal of the VNO, demonstrating that vomeronasal inputs are necessary to achieve copulation in these animals.…”

Section: Olfactory Control Of Sexual Behaviormentioning

confidence: 99%

The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

Keller

Baum

Brock

et al. 2009

Behavioural Brain Research

147

101

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“…Thus, it seems likely that matinginduced MPOA DA release is largely regulated through vomeronasal input. In this regard, vomeronasal lesions are less effective in male hamsters with prior sexual experience (Meredith, 1986). Accordingly, the effects of vomeronasal lesions on MPOA DA release should be examined in sexually naïve males.…”

Section: Discussionmentioning

confidence: 99%

Chemosensory Cues are Essential for Mating-Induced Dopamine Release in MPOA of Male Syrian Hamsters

Triemstra

Nagatani

Wood

2005

Neuropsychopharmacol

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The medial preoptic area (MPOA) is crucial for male sex behavior. Dopamine (DA) is released in MPOA during copulation, and contributes to the reinforcing effects of mating. The aim of the present study was to identify sensory stimuli responsible for matinginduced DA release. Specifically, we determined if chemosensory cues are essential for mating-induced MPOA DA release using in vivo microdialysis in male Syrian hamsters. Hamsters were used because chemosensory cues from the olfactory mucosa and vomeronasal organ are essential for sexual behavior in this species. Sexually experienced adult male hamsters were implanted with a microdialysis guide cannula over MPOA. At the same time, males received sham olfactory bulbectomy (Sham Bx, n ¼ 11), bilateral bulbectomy (Bibx, n ¼ 6), or unilateral bulbectomy (Ubx) ipsilateral (Ipsi Ubx, n ¼ 9) or contralateral (Contra Ubx, n ¼ 8) to the microdialysis probe. This model takes advantage of the predominantly ipsilateral projections of the olfactory bulbs. Microdialysis samples were collected from the MPOA during baseline, exposure to a receptive female, and after removal of female. Extracellular DA was measured using highperformance liquid chromatography with electrochemical detection. During mating, DA increased in MPOA of Sham Bx males (to 146.7717.5% of baseline). Bibx males did not mate, and MPOA DA did not increase (96.1715.8% of baseline). Although both groups of Ubx males mated to ejaculation, MPOA DA increased significantly only in Contra Ubx males (to 161.8735.3% of baseline), and not in males with Ipsi Ubx (107.6711.5% of baseline). The results demonstrate that chemosensory cues are essential for MPOA DA release during mating in male Syrian hamsters.

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Vomeronasal organ removal before sexual experience impairs male hamster mating behavior

Cited by 181 publications

References 32 publications

Sexual behavior in male rodents

Sexual behavior in male rodents

The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

Chemosensory Cues are Essential for Mating-Induced Dopamine Release in MPOA of Male Syrian Hamsters

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