The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

Keller, Matthieu; Baum, Michael J.; Brock, Olivier; Brennan, Peter; Bakker, Julie

doi:10.1016/j.bbr.2009.01.020

Cited by 145 publications

(107 citation statements)

References 120 publications

(188 reference statements)

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“…Here we focused on the SVZ neurogenic niche, which generate newborn neurons fated to the OB region (Tong andAlvarez-Buylla, 2014, Hamson et al, 2013). Surprisingly, only a 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 14 few studies are at the moment available concerning the impact of gonadal hormones on OB neurogenesis (Smith et al, 2001, Hoyk et al, 2006, Brock et al, 2010, Veyrac and Bakker, 2011, despite their contribution to olfactory reproductive behavior (Keller et al, 2009), and recent data supporting a link between OB neurogenesis and reproduction (reviewed in Peretto and Paredes, 2014).…”

Section: Discussionmentioning

confidence: 99%

Testosterone and estradiol differentially affect cell proliferation in the subventricular zone of young adult gonadectomized male and female rats

et al. 2015

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Steroid hormones are important players to regulate adult neurogenesis in the dentate gyrus of hippocampus, but their involvement in the regulation of the same phenomenon in the subventricular zone (SVZ) of the lateral ventricles is not completely understood. Here, in male rats, we tested the existence of activational effects of Testosterone (T) on cell proliferation in the adult SVZ. To this aim, three groups of male rats: castrated, castrated and treated with T, and controls were treated with BrdU and killed after 24 hours. The density of BrdU labeled cells was significantly lower in castrated animals in comparison to the other two groups, thus supporting a direct correlation between SVZ proliferation and levels of circulating T. To clarify whether this effect is purely androgen-dependent, or mediated by the T metabolites, estradiol (E 2 ) and dihydrotestosterone (DHT), we evaluated SVZ proliferation in castrated males treated with E 2 , DHT and E 2 +DHT, in comparison to T-and vehicle-treated animals, and sham-operated controls. The stereological analysis demonstrated that E 2 and T, but not DHT, increase proliferation in the SVZ of adult male rats. Quantitative evaluation of cells expressing the endogenous marker of cell proliferation PHH3, or the marker of highly dividing SVZ progenitors Mash1, indicated the effect of T/E 2 is mostly restricted to SVZ proliferating progenitors. The same experimental protocol was repeated on ovariectomized female rats treated with E 2 or T. In this case, no statistically significant difference was found among groups. Overall, our results clearly show that the gonadal hormones T and E 2 represent important mediators of cell proliferation in the adult SVZ. Moreover, we show that such effect is restricted to males, supporting adult neurogenesis in rats is a process differentially modulated in the two sexes.

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Section: Discussionmentioning

confidence: 99%

Testosterone and estradiol differentially affect cell proliferation in the subventricular zone of young adult gonadectomized male and female rats

et al. 2015

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“…It is not surprising that modalities whose outputs are open to conscious introspection would be those that were noticed first. The methods of modern science later revealed the more hidden systems, such as an older visual system mediated by the superior colliculus that does not usually reach conscious experience, and an accessory olfactory system believed to be involved in pheromone detection (Keller, Baum, Brock, Brennan, & Bakker, 2009). All of the original modalities have components.…”

Section: Conclusion and Caveatsmentioning

confidence: 99%

A perception theory in mind–body medicine: guided imagery and mindful meditation as cross-modal adaptation

Bedford

2011

Psychon Bull Rev

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A new theory of mind-body interaction in healing is proposed based on considerations from the field of perception. It is suggested that the combined effect of visual imagery and mindful meditation on physical healing is simply another example of cross-modal adaptation in perception, much like adaptation to prism-displaced vision. It is argued that psychological interventions produce a conflict between the perceptual modalities of the immune system and vision (or touch), which leads to change in the immune system in order to realign the modalities. It is argued that mind-body interactions do not exist because of higher-order cognitive thoughts or beliefs influencing the body, but instead result from ordinary interactions between lower-level perceptual modalities that function to detect when sensory systems have made an error. The theory helps explain why certain illnesses may be more amenable to mind-body interaction, such as autoimmune conditions in which a sensory system (the immune system) has made an error. It also renders sensible erroneous changes, such as those brought about by "faith healers," as conflicts between modalities that are resolved in favor of the wrong modality. The present view provides one of very few psychological theories of how guided imagery and mindfulness meditation bring about positive physical change. Also discussed are issues of self versus non-self, pain, cancer, body schema, attention, consciousness, and, importantly, developing the concept that the immune system is a rightful perceptual modality. Recognizing mind-body healing as perceptual cross-modal adaptation implies that a century of cross-modal perception research is applicable to the immune system.

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“…However, the VNS is linked via development, neural connectivity and functional overlap to the MOS, and findings in the MOS may apply to other chemosensory systems. The concept of absolute separation between the two systems has been overturned; both can detect general odorants and pheromones (Spehr et al, 2006; Keller et al, 2009), and the respective central projections are highly interconnected (Mucignat‐Caretta et al, 2012). Martínez‐García et al (2009) suggested that MOS and VNS are complementary, the MOS detecting volatile stimuli related to diet, activity pattern, habitat, navigation and sociosexual signals (Jacobs, 2012), and VNS detecting nonvolatile stimuli for sociosexual behavior and predator avoidance (Døving and Trotier, 1998; Fortes‐Marco et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Seasonal morphometry of the vomeronasal organ in the marsupial mouse, Antechinus subtropicus

Aland

Gosden

Bradley

2016

Journal of Morphology

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The vomeronasal system consists of a peripheral organ and the connected central neuronal networks. The central connections are sexually dimorphic in rodents, and in some species, parameters of the vomeronasal organ (VNO) vary with sex, hormonal exposure, body size and seasonality. The VNO of the dasyurid marsupial mouse, Antechinus subtropicus is presumed to be functional. The unusual life history (male semelparity) is marked by distinct seasonality with differences in hormonal environments both between males and females, and in males at different time points. Body size parameters (e.g., length, weight) display sexual dimorphism and, in males, a pronounced weight gain before breeding is followed by a rapid decline during the single, short reproductive season. VNO morphometry was investigated in male and female A. subtropicus to identify possible life cycle associated activity. The overall length of the VNO is positively correlated with the size of the animal. The amount of sensory epithelium exhibits a negative correlation, decreasing with increasing size of the animal. The effects of sex and breeding condition are not obvious, although they do suggest that sensory vomeronasal epithelium mass declines in the breeding period. The VNO may be more important in A. subtropicus before breeding when it may participate in synchronising reproduction and in the development of the male stress response. J. Morphol. 277:1517–1530, 2016. © 2016 Wiley Periodicals, Inc.

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The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

Cited by 145 publications

References 120 publications

Testosterone and estradiol differentially affect cell proliferation in the subventricular zone of young adult gonadectomized male and female rats

Testosterone and estradiol differentially affect cell proliferation in the subventricular zone of young adult gonadectomized male and female rats

A perception theory in mind–body medicine: guided imagery and mindful meditation as cross-modal adaptation

Seasonal morphometry of the vomeronasal organ in the marsupial mouse, Antechinus subtropicus

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