Background: The volvulus of the gallbladder is a rotation of the gallbladder around its cystic pedicle. It is a relatively rare disease in the literature. Only 400 cases have been described. The diagnostic may be difficult in preoperative. The aim of our study is to report an observation of gallbladder volvulus to discuss its diagnostic and therapeutic management in relation to the literature. Observation: A 63-year-old woman was admitted for febrile hepatic colic. The biological examination revealed an hyperleukocytosis at 12000G/L, ASAT was at three times normal and ALAT at four times normal. Total bilirubin and conjugated bilirubin were without particularity. The most likely diagnosis was an acute cholecystitis in front of the clinical status, leading to ultrasound of the liver and bile ducts. The scanographic explorations had suspected a torsion of gallbladder. The diagnosis of gallbladder volvulus was made intraoperatively during exploratory laparotomy. The gallbladder was gangrened, twisted in a turn of the clockwise. The cholecystectomy was made after detorsion. The evolution was favorable. Conclusion: The volvulus of the gallbladder is a rare cause of acute cholecystitis. The medical imaging is a key element for the diagnostic. The prognosis is good in front of an early diagnosis. The cholecystectomy is the only surgery treatment.