Voluntary Exercise Protects Heart from Oxidative Stress in Diabetic Rats

Naderi, Roya; Mohaddes, Gisou; Mohammadi, Mustafa; Ghaznavi, Rana; Ghyasi, R; Vatankhah, Amir Mansour

doi:10.15171/apb.2015.032

Cited by 38 publications

(27 citation statements)

References 33 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could be explained by the activation of PGC-1α, which in addition to increasing antioxidant levels also regulates the expression of VEGF and angiogenesis in skeletal and cardiac muscle cells [49]. In addition to SOD, and CAT produced by the cardiac muscle can lead to vascular improvements [46,50].…”

Section: Discussionmentioning

confidence: 99%

Swimming Exercise Modifies Oxidative Stress in Skeletal and Cardiac Muscles of Diabetic Rats

Pio

Orzari²,

Alves

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: Oxidative stress is a key factor in the worsening of diabetes, requiring an increase in the activity of the antioxidant system, culminating in a balance in the body. The aim of the present study was to evaluate the redox state in the skeletal and cardiac muscles in rats induced to diabetes model and submitted to swimming exercise training for 4 weeks. Methods: Wistar rats were separated into the following four groups: untrained control (C); trained control (T); untrained alloxan-induced diabetes (D); trained alloxan-induced diabetes (TD). The animals were submitted to swimming exercise training for 4 weeks. The redox state of skeletal and cardiac muscles was analyzed by TBARS, -SH groups and, H2O2 production as well as by the SOD and Catalase activity. Besides, a histomorphometry analysis was performed in the cardiac muscle in which the total number of cardiomyocytes and the total area of collagen fibers were measured.Results: On the Soleus muscles, the TD group showed increased of H2O2 and Catalase compared to T group; and SOD compared to D group. About the red gastrocnemius, TD group presented higher SOD and lower Catalase relation to D group. Regarding to cardiac muscle, TD group presented lower TBARS than D group, while it was higher in -SH groups and Catalase compared to D group. Moreover, the swimming exercise led to a decrease in hyperglycemia, benefits in pathogenesis and physio-pathogenesis, evidenced by a reduced number of cardiomyocytes and area of collagen fibers. Conclusions: The swimming protocol exercise in diabetic rats was able to control the hyperglycemia, control of oxidative damage and minimize the fibrosis on cardiac muscle in diabetic rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Swimming Exercise Modifies Oxidative Stress in Skeletal and Cardiac Muscles of Diabetic Rats

Pio

Orzari²,

Alves

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Other possible mechanisms are increasing of VEGF-A and decreasing of oxidative stress by voluntary exercise. 16 …”

Section: Discussionmentioning

confidence: 99%

“…Rats with a blood glucose level ≥300 mg/dL were considered to be diabetic. 16 Induction of diabetes in animals was performed seven days after castration surgery.…”

Section: Methodsmentioning

confidence: 99%

Testosterone and Voluntary Exercise, Alone or Together Increase Cardiac Activation of AKT and ERK1/2 in Diabetic Rats

Chodari¹,

Mohammadi²,

Mohaddes³

et al. 2016

Arquivos Brasileiros De Cardiologia

Self Cite

View full text Add to dashboard Cite

BackgroundImpaired angiogenesis in cardiac tissue is a major complication of diabetes. Protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling pathways play important role during capillary-like network formation in angiogenesis process.ObjectivesTo determine the effects of testosterone and voluntary exercise on levels of vascularity, phosphorylated Akt (P- AKT) and phosphorylated ERK (P-ERK) in heart tissue of diabetic and castrated diabetic rats.MethodsType I diabetes was induced by i.p injection of 50 mg/kg of streptozotocin in animals. After 42 days of treatment with testosterone (2mg/kg/day) or voluntary exercise alone or in combination, heart tissue samples were collected and used for histological evaluation and determination of P-AKT and P-ERK levels by ELISA method.ResultsOur results showed that either testosterone or exercise increased capillarity, P-AKT, and P-ERK levels in the heart of diabetic rats. Treatment of diabetic rats with testosterone and exercise had a synergistic effect on capillarity, P-AKT, and P-ERK levels in heart. Furthermore, in the castrated diabetes group, capillarity, P-AKT, and P-ERK levels significantly decreased in the heart, whereas either testosterone treatment or exercise training reversed these effects. Also, simultaneous treatment of castrated diabetic rats with testosterone and exercise had an additive effect on P-AKT and P-ERK levels.ConclusionOur findings suggest that testosterone and exercise alone or together can increase angiogenesis in the heart of diabetic and castrated diabetic rats. The proangiogenesis effects of testosterone and exercise are associated with the enhanced activation of AKT and ERK1/2 in heart tissue.

show abstract

“…The authors concluded that the exercise-mediated enhancement of the antioxidant defense mechanism in muscle is most likely the underlying mechanism for the protection of muscle cells against oxidative damage [186]. Notably, a 6-week intervention with self-estimated, moderate-intensity CVE training, resulted in positive changes in MDA, SOD, GPx and catalase activities, in the heart tissue of Wistar rats [187], suggesting that even exercise at a voluntary-adjusted intensity is an efficient strategy for improving heart function.…”

Section: Regular Cardiovascular Exercise Trainingmentioning

confidence: 99%

“…Animal-based studies have consistently demonstrate that regular CVE training enhances the activity of endogenous antioxidants and reduces the levels of oxidative stress and inflammation in various tissues, particularly in skeletal and cardiac muscle [183][184][185][186][187][188][189]. For example, Chis et al [183] showed that participation in a 4-week programme of moderate-intensity swimming, resulted in improved hyperglycemia, hypertriglyceridemia, hypercholesterolemia and antioxidant status as indicated by the increased levels of SOD and catalase and decreased MDA, PC, NOx and iNOx levels, in aortic tissue of diabetic Wistar rats.…”

Section: Regular Cardiovascular Exercise Trainingmentioning

confidence: 99%

Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining

et al. 2019

View full text Add to dashboard Cite

Although low levels of reactive oxygen species (ROS) are beneficial for the organism ensuring normal cell and vascular function, the overproduction of ROS and increased oxidative stress levels play a significant role in the onset and progression of cardiovascular diseases (CVDs). This paper aims at providing a thorough review of the available literature investigating the effects of acute and chronic exercise training and detraining on redox regulation, in the context of CVDs. An acute bout of either cardiovascular or resistance exercise training induces a transient oxidative stress and inflammatory response accompanied by reduced antioxidant capacity and enhanced oxidative damage. There is evidence showing that these responses to exercise are proportional to exercise intensity and inversely related to an individual's physical conditioning status. However, when chronically performed, both types of exercise amplify the antioxidant defense mechanism, reduce oxidative stress and preserve redox status. On the other hand, detraining results in maladaptations within a time-frame that depends on the exercise training intensity and mode, as high-intensity training is superior to low-intensity and resistance training is superior to cardiovascular training in preserving exercise-induced adaptations during detraining periods. Collectively, these findings suggest that exercise training, either cardiovascular or resistance or even a combination of them, is a promising, safe and efficient tool in the prevention and treatment of CVDs.

show abstract

Voluntary Exercise Protects Heart from Oxidative Stress in Diabetic Rats

Cited by 38 publications

References 33 publications

Swimming Exercise Modifies Oxidative Stress in Skeletal and Cardiac Muscles of Diabetic Rats

Swimming Exercise Modifies Oxidative Stress in Skeletal and Cardiac Muscles of Diabetic Rats

Testosterone and Voluntary Exercise, Alone or Together Increase Cardiac Activation of AKT and ERK1/2 in Diabetic Rats

Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining

Contact Info

Product

Resources

About