Testosterone and Voluntary Exercise, Alone or Together Increase Cardiac Activation of AKT and ERK1/2 in Diabetic Rats

Chodari, Leila; Mohammadi, Mustafa; Mohaddes, Gisou; Alipour, Mohammad Reza; Ghorbanzade, Vajiheh; Dariushnejad, Hassan; Mohammadi, Shima

doi:10.5935/abc.20160174

Cited by 14 publications

(11 citation statements)

References 39 publications

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“…These receptors appear to mediate the effects of TES via rapid activation of ERK1/2, Akt, and CREB signaling cascades. Similarly, there is evidence that a membrane-associated G protein-coupled TES receptor mediates AR-independent effects as well as modulates genomic effects of TES via ERK1/2/Akt pathways [ 59 – 61 ]. One of these receptors has been associated with beneficial effects of TES in the heart via the PI3/Akt pathway [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens

2020

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Background: Acutely, testosterone (TES) and other androgens are efficacious vasodilators, both in vitro and in vivo; however, their long-term effects on arterial blood pressure (BP) remain unclear. It was hypothesized that endogenous androgens exert long-term anti-hypertensive effects on systemic BP through a combination of genomic and nongenomic effects to enhance vasodilation of the systemic vasculature. Methods: The long-term effects of endogenous TES and exogenous TES replacement therapy (TRT) on BP were studied in intact (InT) and castrated (CsX) male Sprague-Dawley (SD) and testicular-feminized male (Tfm, androgen receptor defective) rats (12 weeks old). Systolic BP (tail-cuff plethysmography) was determined weekly for 15 weeks in InT-control and CsX rats. Some CsX-SD rats received androgen replacement therapy at 10-15 weeks with TES-enanthate (TRT; 1.75 mg/kg, 2x/week) or DHT-enanthate (DRT; 1.00 mg/kg. 2x/week) and a separate group of CsX-SD rats received losartanpotassium in drinking water (LST, 250 mg/L) for the entire 15 week period. Expression of renin, angiotensinogen (Agt), angiotensin converting enzyme (ACE), and angiotensin II type I receptor (AT 1 R) mRNA in kidney and aorta were determined by real-time PCR (rt-PCR) and plasma renin levels were determined by radioimmunoassay.

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Section: Discussionmentioning

confidence: 99%

Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens

2020

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“…In exhaustive exercise, oxidative stress induces through generation of reactive oxygen species (ROS) but voluntary exercise is beneficial to our health that considered mild to moderate exercise (6). Our previous studies in male wistar rats showed that voluntary exercise is an efficient therapeutic approach to diabetes complications (7,8).…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress is Markedly Reduced by Combined Voluntary Exercise and Testosterone in the Heart of Diabetic Rats

Chodari

Smailnejad

Fallahi³

et al. 2019

Acta Endo (Buc)

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Objective. Cardiovascular disorders in diabetes condition arise from increased oxidative stress. Both regular mild exercise and testosterone influence on body's antioxidant system in diabetes. In this study, we evaluated treatment of testosterone and voluntary exercise, alone or together on oxidative stress in the heart and blood of diabetic rats. Methods. Type 1 diabetes was induced by intraperitoneal injection of 50 mg/kg of streptozotocin in rats. Sixty three rats have been divided into eight groups as follows: Diabetes, diabetes+ testosterone, diabetes+ exercise, diabetes+ testosterone+ exercise, diabetes+ castration, diabetes+ castration+ testosterone, Diabetes+ castration+ exercise, Diabetes+ castration+ exercise+ testosterone. Type 1 diabetes was induced by intraperitoneal injection of 50 mg/ kg of streptozotocin in the male Wistar rats and after a week, castration was performed. After 42 days of treatment with testosterone (2 mg/kg/day) or voluntary exercise alone or in combination, SOD, GPX and CAT activities and MDA levels were measured in the blood and heart tissue samples in the groups of study. In the end of study, SOD, GPX and CAT activities and MDA levels were measured in blood and heart tissue samples in the groups of study. Results. SOD, GPX and CAT activities significantly (p<0.05) increased in groups that treated either testosterone or exercise and MDA level significantly (p<0.01) decreased in the blood and heart tissue of diabetic and castrated diabetic rats. Simultaneously, treatment with testosterone and exercise had a synergistic effect on antioxidant enzymes level in diabetic and diabetic castrated rats. In the castrated animals with diabetes, SOD, GPX and CAT activities significantly decreased (p<0.05) and MDA levels significantly increased (p<0.05) in blood and heart tissue. Conclusion. Voluntary exercise and testosterone alone or together heightened body's antioxidant system and were able to reduce the MDA levels in blood and heart of diabetic and castrated diabetic rats.

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“…In 2011, Lu and colleagues showed that troxerutin activates the PI3K / Akt pathway [26]. The PI3K / Akt signaling pathway plays an important role in the survival, apoptosis, metabolism and proliferation of cells [27]. Probably, troxerutrin decreases the rate of apoptosis in -pancreatic cells by activation of PI3K / Akt signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

The effect of troxerutin on alterations of lipid profile and biochemical enzymes in blood of rats with chronic diabetes

badazadeh

Ghorbanzadeh

Chodari

2017

ijpm

Self Cite

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A b s t r a c tDiabetes Mellitus (DM) is a progressive disease that leads to complex disorders such as biochemical changes in the blood. The use of medicinal plants are superior to synthetic drugs because of the few side troxerutin on lipid profile and biochemical enzymes in the blood of type 1 diabetic rats. 32 male Wistar rats (200 control+ troxerutin, diabetes+ troxerutin. Type 1 diabe streptozotocin (50 mg/kg) in animals in diabetic groups. Lasted for 4 weeks, oral administration of troxerutin (150 mg/kg) was carried daily for 4 weeks. At the end of study, anesthesia was induced intraperitoneally with for measuring lipid profile and biochemical enzymes in blood of rats. Diabete significantly increased LDL, COL, TG and significantly decreased HDL compared to the control group. Treatment diab LDL, COL, TG and significantly increased HDL. ALT, AST, LDH, and CPK in blood of rats. Treatment diabetic rats with troxerutin for 4 weeks significa group.Troxerutin improve the lipid profile and reduce biochemical enzymes in blood of diabetic rats.In this way could be useful in reducing the complications of diabetes. Key

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Testosterone and Voluntary Exercise, Alone or Together Increase Cardiac Activation of AKT and ERK1/2 in Diabetic Rats

Cited by 14 publications

References 39 publications

Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens

Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens

Oxidative Stress is Markedly Reduced by Combined Voluntary Exercise and Testosterone in the Heart of Diabetic Rats

The effect of troxerutin on alterations of lipid profile and biochemical enzymes in blood of rats with chronic diabetes

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