Voluntary exercise modulates learning &amp; memory and synaptic plasticity impairments in sleep deprived female rats

Rajizadeh, Mohammad Amin; Esmaeilpour, Khadijeh; Haghparast, Elham; Ebrahimi, Mohammad Navid; Sheibani, Vahid

doi:10.1016/j.brainres.2019.146598

“…A separated set of animals ( n = 6 for each group) was submitted for the electrophysiological experiment. An in vivo study of electrophysiological recording of field excitatory postsynaptic potentials (fEPSPs) from area CA1 was performed according to Rajizadeh et al (Mohammadian et al, 2019; Rajizadeh et al, 2020). For electrophysiological recordings, male Wistar rats were anaesthetized with urethane (1.2 g/kg) (Sigma–Aldrich) and placed in a stereotaxic device.…”

Section: Methodsmentioning

confidence: 99%

Choline chloride modulates learning, memory, and synaptic plasticity impairments in maternally separated adolescent male rats

Shahraki

¹

,

Esmaeilpour

²

,

Shabani

³

et al. 2021

Intl J of Devlp Neuroscience

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Maternal separation (MS) is a model to induce permanent alternations in the central nervous system (CNS) and is associated with increased levels of anxiety and cognitive deficiencies. Since methyl donor choline (Ch) has been shown to play a significant role in learning and memory and enhance synaptic plasticity, the authors hypothesized that Ch may attenuate MS‐induced impairments in synaptic plasticity and cognitive performance. Rat pups underwent an MS protocol for 180 min/day from postnatal day (PND) 1 to 21. Ch was administered subcutaneously (100 mg/kg, 21 days) to the choline chloride and MS + choline chloride groups from PND 29 to 49. Anxiety‐like behaviour, recognition memory, and spatial and passive avoidance learning and memory were measured in the adolescent rats. In addition, evoked field excitatory postsynaptic potentials (fEPSP) were recorded from the CA1 region of the hippocampus. MS induced higher anxiety‐like behaviour in the animals. It also impaired learning and memory. However, MS had no effect on locomotor activity. Subcutaneous administration of Ch attenuated MS‐induced cognitive deficits and enhanced the learning and memory of MS rats. Ch also decreased anxiety‐like behaviour in the open‐field test. The present results showed that long‐term potentiation (LTP) was induced in all groups except MS and MS + saline animals. However, Ch injection induced LTP and had maintenance in MS + choline chloride, but it was not statistically significant compared with the MS group. In summary, the present findings indicate that MS can interfere with normal animal's cognition and subcutaneous of Ch may be considered an appropriate therapeutic strategy for promoting cognitive dysfunctions in MS animals.

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“…The discrimination ratio was calculated in the training and testing phases and is computed as follows: novel/ðnovel + familiar timeÞ. The apparatus and the objects were cleaned between each trial using 70% ethanol to avoid odor trails [40]. The open field consists of a plastic box (90 × 90 × 30 cm).…”

Section: Novel Object Recognition Test the Novel Object Recognition Test Is Used To Assess Recognition Memory In Rodents It Consists Of Tmentioning

confidence: 99%

Resveratrol Attenuates Learning, Memory, and Social Interaction Impairments in Rats Exposed to Arsenic

Zadeh

¹

,

Esmaeilpour

²

,

Aminzadeh

³

et al. 2021

BioMed Research International

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Arsenic (As) toxicity has deleterious effects on human health causing disorder in the brain. The aim of this study was to investigate the possible neuroprotective effect of resveratrol (RSV) on arsenic-induced neurotoxicity in rats. Neurotoxicity in rats was developed by treating As 10 mg/kg/day for 21 days orally. Animals were put into seven groups: control, vehicle, As, As+RSV10, As+RSV20 mg/kg, RSV10, and RSV20 mg/kg. Behavioral assessments such as the social interaction test, novel object recognition test, elevated plus maze, open field, the Morris water maze, in addition to assessment of biomarkers such as ferric reducing ability of plasma assay, glutathione assay, and malondialdehyde assay, were used to evaluate the effects of RSV on cognitive impairment and molecular changes induced by As. The results showed that cognitive performance impaired in As rats. RSV20 mg/kg significantly could ameliorate behavioral changes like spatial learning in days 3 and 4 ( p < 0.05 ), recognition learning and memory ( p < 0.01 ), disabilities in motor coordination and stress ( p < 0.05 ), increased anxiety ( p < 0.05 ), and social interaction deficit (sociability ( p < 0.001 ) and social memory ( p < 0.05 )). RSV20 mg/kg also attenuated molecular modifications like decreased antioxidant power ( p < 0.001 ), reduced glutathione content ( p < 0.05 ), and increased malondialdehyde level ( p < 0.05 ) induced by As. In addition to oxidative stress assessments, RSV10 mg/kg could significantly increase FRAP ( p < 0.01 ) and GSH ( p < 0.05 ); however, MDA was not significantly increased. Our current behavioral findings suggest that RSV has neuroprotective effects against AS toxicity.

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“…When the GR is activated by GCs, this can lead to potentially long‐lasting effects on neural performance that is controlled by the nuclei where these receptors are located (Saleh et al., 2017). While GC receptors are distributed throughout the brain, they are abundant in the hippocampus which affects specified modalities of cognition, the amygdala which affects fear responses and anxiety, and the prefrontal cortex that governs working memory and extinction of learning (Marin et al., 2019; Rajizadeh, Esmaeilpour, et al., 2020). Accordingly, chronic stress leading to long‐lived generation of GCs would be expected to affect all of the cognitive behaviors controlled by the hippocampus, amygdala, and the prefrontal cortex (McEwen, 2012).…”

Section: Introductionmentioning

confidence: 99%

Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Khaleghi

¹

,

Rajizadeh

²

,

Bashiri³

et al. 2021

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Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. Methods In this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress‐induced impairments in cognitive‐behaviors. Adult female Wistar rats at 21–22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MWM) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety‐like behaviors. Results In sham and OVX rats, both physical and psychological stressors were associated with an increase in EPM‐determined anxiety‐like behavior. OVX rats exhibited decreased explorative behavior in comparison with nonstressed sham rats (p < .05). Both physical stress and psychological stress resulted in disrupted spatial cognition as assayed in the MWM (p < .05) and impaired learning and memory as determined by the PA test when the OVX and sham groups were compared with the nonstressed sham group. Estrogen increased explorative behavior, learning and memory (p < .05), and decreased anxiety‐like behavior compared with vehicle in OVX rats exposed to either type of stressor. Conclusions When taken together, estrogen and both stressors had opposite effects on memory, anxiety, and PA performance in a rat model of menopause, which has important implications for potential protective effects of estrogen in postmenopausal women exposed to chronic stress.

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Voluntary exercise modulates learning & memory and synaptic plasticity impairments in sleep deprived female rats

Cited by 34 publications

References 62 publications

Choline chloride modulates learning, memory, and synaptic plasticity impairments in maternally separated adolescent male rats

Choline chloride modulates learning, memory, and synaptic plasticity impairments in maternally separated adolescent male rats

Resveratrol Attenuates Learning, Memory, and Social Interaction Impairments in Rats Exposed to Arsenic

Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

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