Voluntary exercise impact on cognitive impairments in sleep-deprived intact female rats

Sixteen weeks of aerobic training influence spirometry, s-klotho, and hemodynamic responses to sub-maximal exercise testing in obese men with severe obstructive sleep apnea

“…In humans, exercise modalities influence klotho gene expression epigenetically and positively leading to increased expression. 14 Prior studies show improvements in work capacity and performance alike. 15,16 Sleep apnea (SA) is a respiratory disorder that occurs at night with symptoms that may be present during daytime as well.…”

The effects of partial sleep deprivation and the sub-maximal NDKS exercise testing protocol on S-Klotho and hemodynamic responses in women

“…Sleep deprivation (acute and/or chronic) is well documented as an influence of function and performance in both healthy and clinical populations, across sex and age to different extents. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The present study demonstrates a clear and significant influence of partial sleep deprivation on S-Klotho responses to the sub-maximal NDKS exercise test in young, healthy, and trained women, while compared to being non-sleep deprived. The data of this study suggest that partial sleep deprivation of 20hours, is a strong enough stressor, resulting in lower levels of S-Klotho immediate-post, and post-dynamic recovery, while compared to those of the non-sleep deprived state.…”

“…[10][11][12][13] On the other hand, exercise and adaptation to exercise of various exercise modalities such as aerobic training, and resistance training have been proven to negate part and/or all of the adverse effects of sleep deprivation in humans and rats. [14][15][16][17] S-Klotho is an enzyme that in humans is encoded by the KL gene. 18 S-klotho is a type I membrane protein first documented in 1997.…”

The effects of partial sleep deprivation and the maximal ndks exercise testing protocol on s-klotho, maximal oxygen uptake, and hemodynamic responses in young men

“…Sleep deprivation (acute and/or chronic) is well documented as an influencer of function and performance in both healthy and clinical populations, across sex, gender, and age to different extents. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Proper sleep has been indicated as an anti-oxidative factor. 36,37 The present study demonstrates a clear and significant influence of partial sleep deprivation on S-Klotho's response to the maximal NDKS aerobic exercise test in young, healthy, and trained men, while compared to being non-partially sleep deprived.…”

“…[12][13][14][15] On the other hand, in humans and rats, various exercise modalities such as aerobic training, and resistance training negate part and/or all of the adverse effects via positive adaptation in nature. [16][17][18][19] In humans, the S-Klotho enzyme, a type I membrane proteinis encoded by the KL gene. 20,21 Without yet indicating the nature of the influence, the protein is associated with alcohol consumption, the degenerative process, bone lose, and acceleration of aging.…”