Volumetric MRI study of orbito-frontal cortex and thalamus in obsessive-compulsive personality disorder

Increased thalamic volume and decreased thalamo-precuneus functional connectivity are associated with smoking relapse

“…Similarly, increased subcortical volume, such as increased striatal volume, has been reported in the addiction disorders, such as nicotine addiction ( Franklin et al, 2014b , Li et al, 2015 , Yu et al, 2011 ), and cannabis addiction ( Wetherill et al, 2015 ). Additionally, increased thalamic volume has also been reported in other psychiatric disorders characterized by repetitive, compulsive behaviors, such as obsessive–compulsive personality disorder ( Atmaca et al, 2019 ). The mechanism for increased thalamic volume in older established smokers is still unknown.…”

Advances in multimodal data fusion in neuroimaging: Overview, challenges, and novel orientation

“…For MRI measurements of brain structure, linear, area, or volume measurements can be used. The results showed that the area of MCI brain atrophy was consistent with AD, but to a lesser extent, between the normal elderly (control group) and AD patients [64] , [65] , [66] , [67] . Similar results were found using voxel-based measurement and analysis, with abnormal changes in not only gray matter but also white matter [68, 69] .…”

“…For children with OCD, these regions include the bilateral frontal lobe, cingulate cortex, and temporal-parietal junction [162] . For adults with OCD, these regions are the left and right orbitofrontal cortex [67] . Lower volumes were also seen in white matter in the cingulate and occipital cortex, right frontal and parietal and left temporal regions [162] and in a small area of the parietal cortex for patients with OCD [163] .…”

The neurobiology of misophonia and implications for novel, neuroscience-driven interventions

“…The decreased gray matter volume of these areas most obviously affects decision-making and correlates with anxious tendencies such as avoidance behavior ( Reetz et al, 2008 ). Furthermore, OCPD patients have decreased amygdala, hippocampus ( Gurok et al, 2019 ), and OFC volumes, and higher volume in the thalamus ( Atmaca et al, 2019 ), suggesting difficulties with memory, emotional processing, and conscious attention. An fMRI study showed greater functional connectivity within the precuneus, a region that controls memory retrieval and manipulation, in OCPD adults when compared to healthy controls ( Coutinho et al, 2016 ).…”