Volumetric Mapping of Barrett’s Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule

Liang, Kaicheng; Ahsen, Osman O.; Lee, Hsiang‐Chieh; Wang, Zhao; Potsaid, Benjamin; Figueiredo, Marisa; Jayaraman, Vijaysekhar; Cable, Alex; Huang, Qin; Mashimo, Hiroshi; Fujimoto, James G.

doi:10.1038/ajg.2016.419

Cited by 30 publications

(33 citation statements)

References 8 publications

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“…The cycloid scanner enables strip imaging at volumetric rates similar to reported capsule SECM frame rates, but with 3D depth-resolved imaging and nearly 9 × larger strip FOV [37]. The cycloid scanner can be extended to finer transverse resolution using a high NA design, as suggested in previously reported capsule designs using a focusing objective rotated by the micromotor [38,39]. …”

Section: Discussionmentioning

confidence: 92%

“…This work was followed by an OCT variant [36] and another variant with spectrally encoded confocal microscopy (SECM) [37] for side viewing of the esophageal circumference. Our group developed a micromotor tethered capsule using proximal manual pullback for volumetric and en face esophageal OCT imaging of up to 100 cm 2 field-of-view (FOV) in patients, but the manual pullback could not generate rapid volumetric rates [38]. We recently demonstrated what we believe is one of the first distal 2D scanning, circumferential side-viewing scanners incorporated into a tethered capsule, using a micromotor for the rotary (circumferential) scan and a pneumatic scanner for the longitudinal scan [39].…”

Section: Introductionmentioning

confidence: 99%

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Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

Liang

Wang

Ahsen

et al. 2018

Optica

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Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo endoscopic imaging. We demonstrate a new cycloid scanner in a tethered capsule for ultrahigh speed, side-viewing optical coherence tomography (OCT) endomicroscopy in vivo. The cycloid capsule incorporates two scanners: a piezoelectrically actuated resonant fiber scanner to perform a precision, small FOV, fast scan and a micromotor scanner to perform a wide FOV, slow scan. Together these scanners distally scan the beam circumferentially in a 2D cycloid pattern, generating an unwrapped 1 mm × 38 mm strip FOV. Sequential strip volumes can be acquired with proximal pullback to image centimeter-long regions. Using ultrahigh speed 1.3 μm wavelength swept-source OCT at a 1.17 MHz axial scan rate, we imaged the human rectum at 3 volumes/s. Each OCT strip volume had 166 × 2322 axial scans with 8.5 μm axial and 30 μm transverse resolution. We further demonstrate OCT angiography at 0.5 volumes/s, producing volumetric images of vasculature. In addition to OCT applications, cycloid scanning promises to enable precision 2D optical scanning for other imaging modalities, including fluorescence confocal and nonlinear microscopy.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

Liang

Wang

Ahsen

et al. 2018

Optica

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“…Investigators have recently combined VCSEL-based OCT systems with endoscopic probes that incorporate scanning micro-motors to obtain detailed three-dimensional views of BE architecture and blood flow (Fig. 15) [10,44,137]. This volumetric OCT opens new possibilities for obtaining additional features that may improve the diagnosis of BE.…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Gora¹,

Suter²,

Tearney³

et al. 2017

Biomed. Opt. Express

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203

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Abstract:In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forwardviewing probes, along with different scanning mechanisms (proximal-scanning versus distalscanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed. References and links 1. T. Cao and H. L. Tey, "High-definition optical coherence tomography -an aid to clinical practice and research in dermatology," J. Dtsch. Dermatol. Ges. 13(9), 886-890 (2015). 2. J. Olsen, L. Themstrup, and G. B. Jemec, "Optical coherence tomography in dermatology," G. Ital. Dermatol.Venereol. 150(5), 603-615 (2015). 3. M. Ulrich, L. Themstrup, N. de Carvalho, M. Manfredi, C. Grana, S. Ciardo, R. Kästle, J. Holmes, R.Whitehead, G. B. Jemec, G. Pellacani, and J. Welzel, "Dynamic Optical Coherence Tomography in Dermatology," Dermatology (Basel) 232(3), 298-311 (2016). 4. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21(7), 543-545 (1996). 5. A. M. Rollins, R. Ung-Arunyawee, A. Chak, R. C. K. Wong, K. Kobayashi, M. V. Sivak, Jr., and J. A. Izatt, "Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design," Opt. Lett. 24(19), 1358-1360 (1999). 6. M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A.Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51(4), 474-479 (2000). 7. J. Xi, A. Zhang, Z. Liu, W. Liang, L. Y. Lin, S. Yu, and X. Li, "Diffractive catheter for ultrahigh-resolution spectral-domain volumetric OCT imaging," Opt. Lett. 39(7), 2016-2019 (2014). 8. P. H. Tran, D. S. Mukai, M. Brenner, and Z. Chen, "In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe," Opt. Lett. 29(11), 1236-1238 (2004). Goodnow, and C. Petersen, "Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography," Opt. Lett. 29(19), 2261-2263 (2004). 10. T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H.Mashimo, A. E. Cable, and J. G. Fujimoto, "Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology," Biomed. Opt. Express 4(7), 1119-11...

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“…Proximal actuation via a long catheter with multiple bends produces nonuniform rotational and/or longitudinal distortion [4,5]. Recent catheters have used distal rotary scanning micromotors, reducing rotational distortion [6–8]. Our group developed new methods for side-viewing OCT that use distal actuation for 2D scanning [9].…”

mentioning

confidence: 99%

“…The en face plane at shallower depth showed circular/elliptical crypts and structural features reminiscent of crypt lumens. At deeper depths, OCT showed integrated effects of light propagation/backscattering; crypt walls produced high OCT signal, while lumens and stroma produced dark vertical features, resulting in contrast inversion [8]. Imaging of a benign hyperplastic polyp (Fig.…”

mentioning

confidence: 99%

Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

et al. 2017

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Endoscopic optical coherence tomography (OCT) instruments are mostly side viewing and rely on at least one proximal scan, thus limiting accuracy of volumetric imaging and en face visualization. Previous forward-viewing OCT devices had limited axial scan speeds. We report a forward-viewing fiber scanning 3D-OCT probe with 900 µm field of view and 5 µm transverse resolution, imaging at 1 MHz axial scan rate in the human gastrointestinal tract. The probe is 3.3 mm diameter and 20 mm rigid length, thus enabling passage through the endoscopic channel. The scanner has 1.8 kHz resonant frequency, and each volumetric acquisition takes 0.17 s with 2 volumes/s display. 3D-OCT and angiography imaging of the colon was performed during surveillance colonoscopy.

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Volumetric Mapping of Barrett’s Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule

Cited by 30 publications

References 8 publications

Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

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