Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

Liang, Kaicheng; Ahsen, Osman O.; Wang, Zhao; Lee, Hsiang Chieh; Liang, Wenxuan; Potsaid, Benjamin; Tsai, Tsung Han; Giacomelli, Michael G.; Jayaraman, Vijaysekhar; Mashimo, Hiroshi; Li, Xingde; Fujimoto, James G.

doi:10.1364/ol.42.003193

Cited by 37 publications

(27 citation statements)

References 22 publications

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“…For example, OCT showed normal submucosa underneath a rectal polyp near the dentate line and altered its management from a full thickness resection to a less invasive endoscopic mucosal resection (EMR) [76]. High-resolution en face colon images from OCT are analogous to the traditional magnified endoscopic view, but do not require contrast agents; they also yield clinically powerful multi-depth visibility [77]. Thus, OCT has the potential to improve polyp detection and management.…”

Section: Colonmentioning

confidence: 99%

Application of OCT in the Gastrointestinal Tract

Samel

Mashimo

2019

Applied Sciences

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Optical coherence tomography (OCT) is uniquely poised for advanced imaging in the gastrointestinal (GI) tract as it allows real-time, subsurface and wide-field evaluation at near-microscopic resolution, which may improve the current limitations or even obviate the need of superficial random biopsies in the surveillance of early neoplasias in the near future. OCT’s greatest impact so far in the GI tract has been in the study of the tubular esophagus owing to its accessibility, less bends and folds and allowance of balloon employment with optimal contact to aid circumferential imaging. Moreover, given the alarming rise in the incidence of Barrett’s esophagus and its progression to adenocarcinoma in the U.S., OCT has helped identify pathological features that may guide future therapy and follow-up strategy. This review will explore the current uses of OCT in the gastrointestinal tract and future directions, particularly with non-endoscopic office-based capsule OCT and the use of artificial intelligence to aid in diagnoses.

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Section: Colonmentioning

confidence: 99%

Application of OCT in the Gastrointestinal Tract

Samel

Mashimo

2019

Applied Sciences

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“…The volumetric OCT imaging in the colon also allows visualization of en face features for better differentiation of the diseases. 87 Recently, Liang et al 88 developed a forward-viewing OCT probe using a piezoelectric actuator and demonstrated high-resolution en face colon images that are analogous to magnified endoscopic view without requiring contrast agent and providing multidepth visualization. Figure 7 shows in vivo volumetric images from a hyperplastic polyp at an imaging speed of 2 volumes per second, which is an encouraging example of in vivo polyp assessment using OCT.…”

Section: Inflammatory Bowel Disease and Polyps Screening Investigatiomentioning

confidence: 99%

Optical coherence tomography in gastroenterology: a review and future outlook

et al. 2017

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Optical coherence tomography (OCT) is an imaging technique optically analogous to ultrasound that can generate depth-resolved images with micrometer-scale resolution. Advances in fiber optics and miniaturized actuation technologies allow OCT imaging of the human body and further expand OCT utilization in applications including but not limited to cardiology and gastroenterology. This review article provides an overview of current OCT development and its clinical utility in the gastrointestinal tract, including disease detection/differentiation and endoscopic therapy guidance, as well as a discussion of its future applications.

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“…However, this probe has a relatively small field of view (FOV) of 800 μm . First endoscopic OCTA images were also recently demonstrated using a larger probe over a FOV of only 450 μm . No 3D images have been demonstrated and the technique was not sensitive enough to detect small vessels due to a strong noise background present in the images .…”

Section: Introductionmentioning

confidence: 99%

Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe

Wurster

Shah

Placzek

et al. 2019

Journal of Biophotonics

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A forward imaging endoscope for optical coherence tomography angiography (OCTA) featuring a piezoelectric fiber scanner is presented. Imaging is performed with an optical coherence tomography (OCT) system incorporating an akinetic light source with a center wavelength of 1300 nm, bandwidth of 90 nm and A‐line rate of 173 kHz. The endoscope operates in contact mode to avoid motion artifacts, in particular, beneficial for OCTA measurements, and achieves a transversal resolution of 12 μm in air at a rigid probe size of 4 mm in diameter and 11.3 mm in length. A spiral scan pattern is generated at a scanning frequency of 360 Hz to sample a maximum field of view of 1.3 mm. OCT images of a human finger as well as visualization of microvasculature of the human palm are presented both in two and three dimensions. The combination of morphological tissue contrast with qualitative dynamic blood flow information within this endoscopic imaging approach potentially enables improved early diagnostic capabilities of internal organs for diseases such as bladder cancer.

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Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

Cited by 37 publications

References 22 publications

Application of OCT in the Gastrointestinal Tract

Application of OCT in the Gastrointestinal Tract

Optical coherence tomography in gastroenterology: a review and future outlook

Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe

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